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  • 1
    Publication Date: 2011-12-15
    Description: Environmental Science & Technology DOI: 10.1021/es201983t
    Print ISSN: 0013-936X
    Electronic ISSN: 1520-5851
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
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  • 2
    Publication Date: 2015-01-01
    Description: IntroductionThe incidence of breast cancer diagnosed during pregnancy is expected to increase as more women delay childbearing in the United States. Treatment of cancer in pregnant women requires prudent judgment to balance the benefit to the cancer patient and the risks to the fetus. Prospective data on the outcomes of children exposed to chemotherapy in utero are limited for the breast cancer population. Methods: Between 1992 and 2010, 81 pregnant patients with breast cancer were treated in a single-arm, institutional review board-approved study with 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC) in the adjuvant or neoadjuvant setting. Labor and delivery records were reviewed for each patient and neonate. In addition, the parents or guardians were surveyed regarding the health outcomes of the children exposed to chemotherapy in utero. Results: In total, 78% of the women (or next of kin) answered a follow-up survey. At a median age of seven years, most of the children exposed to chemotherapy in utero were growing normally without any significant exposure-related toxicity or health problems. Three children were born with congenital abnormalities: one each with Down syndrome, ureteral reflux, and clubfoot. The rate of congenital abnormalities in the cohort was similar to the national average of 3%. Conclusions: During the second and third trimesters, pregnant women with breast cancer can be treated with FAC safely without concerns for serious complications or short-term health concerns for their offspring who are exposed to chemotherapy in utero. Continued long-term follow-up of the children in this cohort is required.Trial registrationClinicalTrials.gov Identifier: NCT00510367. Other Study ID numbers: ID01-193, NCI-2012-01578. Registration Date: 7/31/2007
    Print ISSN: 1465-5411
    Electronic ISSN: 1465-542X
    Topics: Medicine
    Published by BioMed Central
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  • 3
    Publication Date: 2020-06-04
    Description: This study provides insight into the feasibility of a CO2 trunkline from the Netherlands to the Utsira formation in the Norwegian part of the North Sea, which is a large geological storage reservoir for CO2. The feasibility is investigated in competition with CO2 storage in onshore and near-offshore sinks in the Netherlands. Least-cost modelling with a MARKAL model in combination with ArcGIS was used to assess the cost-effectiveness of the trunkline as part of aDutch greenhouse gas emission reduction strategy for the Dutch electricity sector and CO2 intensive industry. The results show that under the condition that a CO2 permit price increases from €25 per tCO2 in 2010 to €60 per tCO2 in 2030, and remains at this level up to 2050, CO2 emissions in the Netherlands could reduce with 67% in 2050 compared to 1990, and investment in the Utsira trunkline may be cost-effective from 2020–2030 provided that Belgian and German CO2 is transported and stored via the Netherlands as well. In this case, by 2050 more than 2.1 GtCO2 would have been transported from the Netherlands to the Utsira formation. However, if the Utsira trunkline is not used for transportation of CO2 from Belgium and Germany, it may become cost-effective 10 years later, and less than 1.3 GtCO2 from the Netherlands would have been stored in the Utsiraformation by 2050. On the short term, CO2 storage in Dutch fields appears more cost-effective than in the Utsira formation, but as yet there are major uncertainties related to the timing and effective exploitation of the Dutch offshore storage opportunities.
    Keywords: ddc:600
    Repository Name: Wuppertal Institut für Klima, Umwelt, Energie
    Language: English
    Type: article , doc-type:article
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