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  • 1
    Electronic Resource
    Electronic Resource
    Genetic changes in mammalian cells reminiscent of an SOS response (1984)
    Springer
    Human genetics 〈Berlin〉 67 (1984), S. 360-368 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Prior to the isolation of mammalian DNA repair genes and identification of their gene products, the comparison between the bacterial SOS response and various similar reactions in mammalian cells remains rather speculative. The increasing number of observed phenomena including enhanced DNA repair, virus induction, induced cellular differentiation, and neoplastic transformation, all following DNA damage or arrest of replication, are, however, suggestive of an SOS-like system of growth control and may form an entry into this fascinating area.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291392
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  • 2
    Electronic Resource
    Electronic Resource
    Radiation-induced activation of transcription factors in mammalian cells (1990)
    Springer
    Radiation and environmental biophysics 29 (1990), S. 303-313 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary In mammalian cells radiation induces the enhanced transcription of several genes. The cis acting elements in the control region of inducible genes have been delimited by site directed mutagenesis. Several different elements have been found in different genes. They do not only activate gene transcription in response to radiation but also in response to growth factors and to tumor promoter phorbol esters. The transcription factors binding to these elements are present also in non-irradiated cells, but their DNA binding activity and their transactivating capability is increased upon irradiation. The signal chain linking the primary radiation-induced signal (damaged DNA) to the activation of transcription factors involves the action of (a) protein kinase(s).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01210410
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  • 3
    Electronic Resource
    Electronic Resource
    Control of gene expression in bacteriophage T7: Transcriptional controls (1974)
    Springer
    Molecular genetics and genomics 134 (1974), S. 281-287 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Two transcriptional control mechanisms of T7 can be distinguished both affecting the transcription by E. coli RNA polymerase: An early control and an “early-late” control. In wild type infections, both transcriptional control proteins appear at approximately the same time. Mutations in the early control gene have, therefore, little effect on transcription, if tested in the presence of virus RNA polymerase. Using mutants in T7 RNA polymerase, the appearance of the “early-late” control is delayed. Then, the effect of the early control gene is dramatic, its deficiency leading to an overproduction of host and early T7 RNA. The early RNA control appears to be exerted by the T7 protein kinase, the “early-late” control protein is most likely identical with the transcriptional inhibitor, which has been isolated and purified (Ponta et al., 1974). Both control proteins inhibit the initiation of RNA synthesis by E. coli RNA polymerase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00337463
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  • 4
    Electronic Resource
    Electronic Resource
    Control of gene expression in bacteriophage T7 (1974)
    Springer
    Molecular genetics and genomics 134 (1974), S. 29-38 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A transcriptional inhibitor is isolated and purified from phage T7 infected E. coli cells. The inhibitor is a protein of the molecular weight 14000. It interferes with the transcription by E. coli RNA polymerase no matter which template is used but it does not affect the action of T7 RNA polymerase. Inhibition of holoenzyme is more severe than that of core enzyme. The target of inhibition is the RNA polymerase which is blocked in initiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332810
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  • 5
    Electronic Resource
    Electronic Resource
    Ribosomes ofDunaliella (1972)
    Springer
    Protoplasma 75 (1972), S. 303-312 
    Details
    ISSN: 1615-6102
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The ribosomes of the naked flagellateDunaliella spec. which belongs to theVolvocales were isolated and characterized at different Mg2+-concentrations by isokinetic density sedimentation. 80 s ribosomes from the cytosol as well as 70 s ribosomes from the chloroplast are very sensitive against Mg2+-deprivation. The biological meaning of this strong Mg2+-dependence ofDunaliella ribosomes is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01279821
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  • 6
    Electronic Resource
    Electronic Resource
    Ribosomes ofDunaliella (1972)
    Springer
    Protoplasma 75 (1972), S. 359-369 
    Details
    ISSN: 1615-6102
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The high molecular weight ribonucleic acids from the green algaDunaliella were isolated from wholeDunaliella cells and fromDunaliella ribosomes and analysed by the technique of sucrose density centrifugation. Ribonucleic acids from whole cells and fromDunaliella ribosomes showed the same sedimentation profile only when ribosomes were prepared in the presence of the RNase inhibitor polyvinyl sulfate. Otherwise ribonucleic acids fromDunaliella ribosomes were degraded to some extent, as compared with those from whole cells, although the ribosomes were still physically intact. The ribonucleic acids fromDunaliella were resolved by sucrose density centrifugation into three high molecular weight components sedimenting with 26, 23 and 17.5s. The 80s ribosomal fraction contained mainly a 26 and 17.5 s RNA, whereas the 50 s ribosomal fraction contained a 23 s RNA. The 26 s RNA and the 23 s RNA may represent the heavy ribonucleic acids from the cytosol and the chloroplast of the cell respectively, whereas the 17.5 s RNA may be a mixture of the two light RNA's from the two cell compartments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01282115
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  • 7
    Electronic Resource
    Electronic Resource
    Protein kinase ofAcetabularia (1975)
    Springer
    Protoplasma 85 (1975), S. 209-218 
    Details
    ISSN: 1615-6102
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Acetabularia cells contain a protein kinase activity which transfers phosphate from ATP to serine or threonine residues of proteins. The enzyme does not respond to cAMP or cGMP. The specific activity increased during development and reached a maximum just before beginning of cap formation. The kinase appears to be a chloroplast associated enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01567947
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  • 8
    Electronic Resource
    Electronic Resource
    Ribosomes after infection with bacteriophage T4 and T7 (1973)
    Springer
    Molecular genetics and genomics 127 (1973), S. 259-271 
    Details
    ISSN: 1617-4623
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The synthesis of E. coli ribosomal proteins ceases after infection with bacteriophages T4 or T7 as does the synthesis of most other host proteins. The shut-off does not affect all ribosomal proteins to the same extent. After T7 infection no new proteins were detected in NH4Cl-washed ribosomal particles. Bacteriophage T4, however, induces 3–4 new protein bands demonstrated by one-dimensional gel electrophoresis. The appearance of these bands is prevented by the addition of rifampicin at the time of infection but not when rifampicin is added one minute after infection. The NH4Cl-washed ribosomal particles present at the time of T7 or T4 infection do not show any structural changes by sedimentation, subunit dissociation, or protein analysis on two-dimensional polyacrylamide gels. However, by labeling the T7 infected cells with 32P-phosphate, it is seen that the ribosomes become phosphorylated. The 32P-label comigrates with ribosomal proteins. This phosphorylating activity depends on a T7 gene. The T7 protein phosphokinase utilizes ribosomes as phosphate acceptor in vitro. The T7 ribosomes (NH4Cl-washed) still function in vitro as do ribosomal particles from uninfected cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333766
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