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  • 1
    Electronic Resource
    Electronic Resource
    Solubilization of Human Leucocyte Membrane Isoantigens (1968)
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 1180-1181 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Such an advance would also be relevant to efforts to achieve specific immunological tolerance of human tissue grafts. Tolerance in animal systems has been difficult to induce across major histocompatibility loci when crude tissue extracts were used as antigens. Previous studies, however, have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2171180a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pathology of modified graft-versus-host disease in bone marrow allografted monkeys treated with antilymphocyte serum (1975)
    Springer
    Annals of hematology 30 (1975), S. 19-30 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Pathologie der modifizierten graft-versus-host-Krankheit des Rhesusaffen bei Knochenmark-Allotransplantation und Behandlung mit anti-Lymphozytenserum: Rhesusaffen wurden nach letaler Bestrahlung mittels Röntgenstrahlen und60Co mit Knochenmark-Allo- oder Autotransplantat behandelt. Der Allotransplantation folgte eine letale graft-versus-host-Reaktion (GVHR) mit einer mittleren Überlebenszeit von 9,1 Tagen; autotransplantierte Tiere ohne GVHR überlebten mehr als 500 Tage. Behandlung mit anti-Lymphozytenserum vor Übertragung allogenen Markes führte zu einer Verlängerung der Überlebenszeit bis zum Mittel von 43 Tagen. Diese Tiere zeigten histologische Zeichen einer “chronischen” GVHR und Sepsis als Folge einer mangelhaften Rekonstitution des lymphoretikulären Systems. Im Rahmen dieser “Defektheilung” kam es zu schweren bakteriellen Darmerkrankungen, die offenbar als Eintrittspforte für septische Allgemeininfektionen dienten.
    Notes: Summary Lethally irradiated rhesus monkeys were used for bone marrow allografting and autografting. Monkeys receiving allogeneic bone marrow developed acute graftversus-host reaction (GVHR) and had a mean survival time of 9.1 days as compared to autografted monkeys which survived above 500 days. Treatment with antilymphocyte sera (ALS) before allografting modified the GVHR and extended the survival time to an average of 43 days. Histologically, such animals showed evidence of “chronic” GVHR and septicemia secondary to a lack in lymphoreticular recovery. Subsequently, severe GI-tract infections followed which usually served as portal of entry for septicemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01633783
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of Heparin on the Detection of Human Isoantigens by the Cytotoxicity Technique (1970)
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 951-952 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two human lymphoid tissue culture lines, IM-1 and RPMI 4265, were used as target cells in the cytotoxicity reactions10. IM-1 cells were washed twice in Eagle's medium with 10 per cent foetal bovine serum and incubated as in the procedure of Lippman7 with 0.1,000 pig sodium heparinate (Hynson, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/225951a0
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    Paper (German National Licenses)
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