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  • 1
    Electronic Resource
    Electronic Resource
    Blue-green fluorescence excited by UV laser on leaves of different species originates from cutin and is sensitive to leaf temperature (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Plant, cell & environment 17 (1994), S. 0 
    Details
    ISSN: 1365-3040
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Under ultra-violet excitation, intact leaves generate a strong blue-green fluorescence emission with several bands. Their integrated energy is 6 to 11 times the energy released by chlorophyll a bands (Chappelle et al. 1984, Applied Optics 23, 134–138). This paper provides evidence that the blue-green fluorescence emission comes mainly from outer epidermal layers of the leaves and can be transferred on a quartz lamina by quickly dipping the leaves in organic solvents with subsequent solvent evaporation. Blue-green fluorescence displays a diffusion-controlled quenching of fluorescence intensity between 4°C (high fluorescence) and 37°C (low fluorescence). The blue-green fluorescence emissivity is not linked to short-term metabolic effects other than leaf temperature, but epidermis adaptations both to drought and to excessive radiation increase emissivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3040.1994.tb00171.x
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of polycyclic hydrocarbons on the synthesis of DNA in lymphoid organs, bone marrow and regenerating rat liver (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 358-360 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Riassunto È esaminato l'effetto di sette idrocarburi policiclici, a diverso potere oncogeno, sulla sintesi del DNA nel timo, milza, midollo e fegato rigenerante di ratto. Il DMBA è inibente in tutti i tessuti esaminati, come pure il 1,2,3,4-DBA. Il BP ha un notevole effetto solo sul fegato rigenerante mentre il 1,2,3,4-DBA é più efficace dell'1,2,5,6-DBA in ogni caso. Non é stata stabilita una correlazione tra il potere oncogeno delle sostanze esaminate e la inibizione della sintesi del DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01922585
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of diphtheria toxin-resistant mutants in human cells by halogenated compounds (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 111-112 
    Details
    ISSN: 1432-1335
    Keywords: Halogenated compounds ; Mutagenicity ; Cytotoxicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mutagenic power of 1,2-dichloroethane, 1,2-dibromoethane, 1,2-diiodoethane was tested in the human cell line, EUE. In our mutagenic system, based on selection against diphtheria toxin, the halogenated compounds, 1,2-dichloroethane and 1,2-dibromoethane revealed a strong mutagenic effect, whereas 1,2-diiodoethane was not mutagenic at a concentration allowing survival of 41%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391843
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  • 4
    Electronic Resource
    Electronic Resource
    Biomonitoring of exposure to ethylene oxide and propylene oxide by determination of hemoglobin adducts: correlations between airborne exposure and adduct levels (1999)
    Springer
    International archives of occupational and environmental health 72 (1999), S. 142-150 
    Details
    ISSN: 1432-1246
    Keywords: Key words Ethylene oxide ; Propylene oxide ; Hemoglobin adducts ; Biomarkers ; Exposure monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objectives: Ethylene oxide (EO) and propylene oxide (PO) are important industrial chemicals. Exposure to these directly acting mutagens may be monitored by determination of their adducts to hemoglobin (Hb). This study establishes correlations between airborne concentrations of EO and PO and their Hb adducts in petrochemical workers. Methods: In three different studies conducted during maintenance shutdown of petrochemical plants the external occupational exposure to EO and PO was assessed by personal air monitoring (PAM). The internal exposure to EO and PO was concomitantly assessed by determination of N-(2-hydroxyethyl)valine (HOEtVal) and N-(3-hydroxypropyl)valine (HOPrVal) in blood samples of the operators using the N-alkyl-Edman degradation method. Results: In the first study, PAM was applied once a month at random over a period of 4 months. Blood samples for Hb-adduct determination were collected at the end of this period. No significant correlation was found between PAM and Hb-adduct data. In the next two studies, PAM was applied to the operators during the entire shift on every working day during the shutdown. Blood samples were collected before and immediately after the shutdown period. Highly significant correlations were found between the increment in the concentration of HOEtVal and HOPrVal over this period and the total exposure to EO and PO, respectively. Conclusions: Time-integrated exposure to EO or PO can be readily and reliably assessed by measurement of the concentration of HOEtVal or HOPrVal in a small blood sample. In workers occupationally exposed to low concentrations of EO or PO, good correlations were found between these Hb adducts and the airborne concentrations of EO and PO. These correlations allow the calculation of tentative biological exposure limits (BELs) for EO and PO. At the current Dutch occupational exposure limit (OEL) for EO (0.84 mg m−3, 8-h TWA) the BEL is 3.2 nmol HOEtVal/g globin. At the value of 10 mg m−3 (8-h TWA), which is currently being investigated as the new Dutch OEL for PO, the corresponding BEL is 5.3 nmol HOPrVal/g globin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004200050353
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of urethan on the synthesis of nucleic acids in the cells of regenerating rat liver (1974)
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 277-283 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach partieller Hepatektomie und Gabe von 1 mg/g Körpergewicht Urethan zum Beginn der S-Phase, d. h. 19 Std nach dem Eingriff, wurde der beginnende Anstieg der DNA-Synthese reversibel gehemmt. Ein Hemmeffekt auf die gesamte, die lösliche, die mitochondriale und die mikrosomale RNA wurde bis 36 Std nach Hepatektomie beobachtet.
    Notes: Summary By administration of urethane (1 mg/g body weight) at the beginning of the S phase i. e. 19 hr after partial hepatectomy the initial rise in DNA synthesis was reversibly inhibited. An inhibitory effect on the total, the soluble, the mitochondral and the microsomal RNA was demonstrated up to 36 hr after hepatectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285562
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of urethan on the synthesis of nucleic acids in thymus, spleen, and bone marrow (1975)
    Springer
    Journal of cancer research and clinical oncology 84 (1975), S. 281-289 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Urethan, in a single dose of 1 mg/g body weight, exerts a strong inhibitory effect on DNA synthesis in lymphoid organs and bone marrow of rat. The inhibition observed in spleen and thymus is longer lasting than that exerted on bone marrow or regenerating liver, demonstrating a marked sensitivity of lymphoid cells to the drug. This effect can explain the rapid reduction of weight and cell number in thymus and spleen under urethan treatment, in absence of any lymphocytolytic action. The different effect of urethan on the different subpopulations of lymphoid cells therefore appears to be due to their kinetics rather than to a specific sensitivity of some of them.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312249
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  • 7
    Electronic Resource
    Electronic Resource
    Metabolism of complex carbohydrates of rabbit skin during treatment with 7,12-dimethylbenz(a)anthracence (1974)
    Springer
    Journal of cancer research and clinical oncology 81 (1974), S. 161-168 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Pinselung mit 7,12-Dimethylbenz[a]anthrazen (DMBA) wurde der Stoffwechsel von Mukopolysacchariden (MPS) und Glykoproteinen in Kaninchenhaut untersucht. Die Synthese und der Turnover von MPS wurde in den frühen Phasen der Behandlung zunehmend erhöht und blieb bei hohen Werten während der Dauer der Behandlung. Sialinsäure enthaltende Glykoproteine aus in Kochsalzlösung löslichen und unlöslichen Fraktionen zeigten ähnliche Unterschiede wie die MPS. Die Ergebnisse stehen in Beziehung zu der Rolle, die dermalen Änderungen während der Hautcarcinogenese zugeschrieben wird.
    Notes: Summary The metabolism of mucopolysaccharides (MPS) and glycoproteins in the rabbit skin was studied after painting with 7,12-Dimethylbenz(a)anthracene (DMBA). The synthesis and turnover of MPS increased progressively in the early phases of treatment and remained at high values for the duration of the treatment. Sialic acid-containing glycoproteins of fractions soluble and insoluble in saline had variations similar to those of MPS. The data are related to the role attributed to the dermal changes during skin carcinogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304155
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  • 8
    Electronic Resource
    Electronic Resource
    Leukemia-inhibitory factor and neuroblastoma cell lines: Study on the expression of this citokine and on its efficacy as differentiating agent (1993)
    Springer
    Cytotechnology 11 (1993), S. S154 
    Details
    ISSN: 1573-0778
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00746084
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  • 9
    Electronic Resource
    Electronic Resource
    Gibberellin and abscisic acid effects on the activity of hydrolytic enzymes in de-embryonated barley seeds (1984)
    Springer
    Plant growth regulation 2 (1984), S. 31-40 
    Details
    ISSN: 1573-5087
    Keywords: Hordeum vulgarae L. ; abscisic acid ; gibberellins ; enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The production of hydrolytic enzymes by embryo-less barley seeds in response to various gibberellins and abscisic acid was investigated. The data support the hypothesis that plant growth substances may affect the mechanisms of hydrolase production and secretion in cereal seeds in different ways and at different point.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00024093
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  • 10
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    Tissue and Tumor NK Cell Alterations in Prostate Cancer (2016)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2016-04-16
    Description: The field of immunotherapy for solid tumors, such as prostate cancer, has been recently focusing on therapies that can counter tumor-mediated immunosuppression. Precise quantification and characterization of the immune infiltrates in tumors is crucial to improve treatment efficacy. Natural killer (NK) cells, major components of the antitumor immune system, have never been isolated from prostate tumors, despite their suspected role in disease progression. Here, we examined the frequency, phenotype, and functions of NK cells infiltrating control and tumor prostate tissues. NK cell infiltrates in prostate tissues were mainly CD56 (NCAM1)-positive and displayed an unexpected immature, but activated, phenotype with low or no cytotoxic potential. Furthermore, we show that TGFβ1 (TGFB1) is highly secreted into the prostate environment and partly mediates the immunosuppressive effects on NK cells. In addition to this basal level of immunotolerance to NK cells, the prostate environment became further resistant to NK cell–mediated immunity upon cancer cell infiltration. Coculture experiments revealed that prostate cancer cells induced the expression of inhibitory receptor (ILT2/LILRB1) and downregulated the expression of activating receptors NKp46 (NCR1), NKG2D (KLRK1), and CD16 (FCGR3) by NK cells, thus preventing their recognition of tumor cells. Notably, blood levels of NKp46 were also decreased in prostate cancer patients and were inversely correlated with levels of prostate-specific antigen, the main prognostic factor in prostate cancer. Our study shows that a strong immunosuppressive environment impairs NK cell function at multiple levels in prostate cancer and provides a rationale for the design of therapies that restore NK cell efficiency in the prostate tumor microenvironment. Cancer Res; 76(8); 2153–65. ©2016 AACR.
    Print ISSN: 0008-5472
    Electronic ISSN: 1538-7445
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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