Note: Cover -- Half Title -- Title Page -- Copyright Page -- Preface -- About the Editors -- Contents -- Contributors -- In Memory of Professor Alex Silberberg1923-1993 -- BASIC SCIENCE -- I. Dynein Regulation -- 1 Molecular Biology of Axonemal Dyneinand Its Role in Ciliary Motility -- 2 Modeling Outer Dynein Arm Activityand Its Relation to the Ciliary Beat Cycle -- II. Ciliary Regulation -- 3 Regulation of Outer Arm Dynein Activity via Light Chain Phosphorylation -- 4 Inhibitory and Excitatory Neural Regulation of the MucociliaryTransport System -- 5 The Nucleoside Diphosphate Kinaseand Chloride-Sensitive GTP-Dependent Phosphorylation in Apical Membrane from Ciliated Airway Cells -- 6 Regulation of Ciliogenesis and Ciliated Cell Specific Genes -- 7 Mucus Transporting Cilia: A Model System for Investigating Calcium Signaling in Electrically lnexcitable Cells -- 8 Intercellular Communication in Mammalian Airway-Ciliated Epithelia -- 9 β2 Agonist Terbutaline Makes theCiliary Beat Frequency of FreshlyIsolated Human Airway CellsRefractory to Calcium Signaling -- 10 Ionic Mechanisms in Olfactory Reception: Perspective Through lon Channels in the Vertebrate Olfactory Cilia -- III. Modeling of Ciliary Function -- 11 Coupling the Internal Axoneme Mechanics of Cilia and Flagella with External Fluid Dynamics -- 12 Metachronal Coordination as the Result of Hydrodynamical Coupling -- 13 Metachronal Wave, Ciliary Stroke, and Mucus Propulsion -- 14 Roles of Cilia in Filter Feeding and Mucous Transport -- IV. Basic Aspect of Mucus -- 15 Digital Microrheometry -- 16 Regulation of Differentiation and Mucin Secretion in Tracheobronchial Epithelial Cell Cultures -- 17 Intracellular Regulation of Mucin Secretion in Airway Epithelial CellsIn Vitro -- 18 Cellular Basis for the Purinergic Regulation of Mucin Secretion in the Airways. , 19 Polymer Biophysics of Mucus in Cystic Fibrosis -- 20 Evolution of the Frog Palate Model for Mucociliary Clearance-1970-1997 -- 21 Airway Mucociliary Epithelium Injury and Repair -- Clinical Practice -- I. Mucociliary Clearance in Various Septal Deformities -- 22 Septal Deformities Can Influence the Mucociliary Transport Impairment of the Middle Turbinate Mucosa -- 23 Aspects of Mucociliary Flow and Mechanics in Nasal Cavity and Sinuses -- II. Clinical Studies in Human Tubal Structures -- 24 Clearance Function of the EustachianTube: What We Know, What We Don't Know -- 25 Clinical Significance of Tubotympanal Mucociliary Clearance in Otitis Media with Effusion -- III. Mucociliary Function of Respiratory Epithelium-Human -- 26 Effects of Urban Air Pollution on Mucociliary Clearance -- IV. Bridging the Gap Between Airway Ion Transport -- 27 Improved Mucociliary Clearance Following Nebulization with Hypertonic Saline in Adults with Cystic Fibrosis -- 28 Ciliary Transportability of Sputum Is Governed by Its Osmolality -- 29 Mucociliary Clearance in the Guinea Pig is Increased by Ouabain (i.v.) andby Hypertonic Saline (14.4o/o) Aerosol -- 30 Interventions that Increase Mucociliary Clearance in Asthmatic and Healthy Subjects -- 31 Mucociliary and Cough Clearance:Role of I on Transport and the P2Y2 Receptor-Mediated System -- V. Laboratory and Clinical Studies of Mucus -- 32 Surface Properties of Respiratory Secretions: Relationship to MucusTransport -- 33 Cellular Components of Airway Secretions: Recruitment and Regulation -- 34 DNA and Actin Filament Ultrastructure in Cystic Fibrosis Sputum -- VI. Airway Bacteria and Mucus Production -- 35 Is Bacterial Colonization of the Airways Relevant? -- 36 Mucin Synthesis Is Upregulated at theTranscriptional Level by P. aeruginosa LPS. , 37 Tissue Distribution of Secretory Mucins and Alterations of Mucin Gene Expression in Chronic H. pyloriInfection of the Stomach -- 38 Effect of Pseudomonas aeruginosa Alginate on Airway Mucus Secretion -- VII. Medical Modulation of Mucus -- 39 Analysis of Mucociliary Dysfunction -- 40 Effects of Mucokinetic Agents on Nasal Mucus -- 41 Pharmacologic Management of Mucus Retention Based on a Taxonomy of Mucoactive Medications -- 42 Experimental Models for Mucus Drug -- VIII. Definition and Diagnosis of Primary and Secondary -- 43 Ciliary Beat Frequency, Ultrastructural Abnormalities, and Mucus Clearance in Primary Ciliary Dyskinesia (PCD) -- 44 Diagnosis of Primary Ciliary Dyskinesia -- 45 Mucociliary Clearance in Healthand Disease: Qualitative and Quantitative Analysis -- 46 Human Ciliated Epithelium In Vitro-Mechanisms of Injury and Protection -- IX. Biochemical and Pharmacological Regulation -- 47 Regulation of Mucociliary Activity in the Upper Airways by Nitric Oxide-Clinical Implications -- 48 Ciliary Stimulation by Extracellular ATP in Frog Esophagus and Palate Epithelium -- 49 The Messianic Relationship Between Inspiration and Expectoration -- X. Mucociliary Clearance in Paranasal Sinuses -- 50 An Approach to Imaging Interpretation in Paranasal Sinus Disease -- XI. Miscellaneous Ciliary Function -- 51 Chronic Sinusitis in Relation to the Lower Airway -- 52 Immune Responses in the Chronic Inflammatory Process Within the Paranasal Sinus Mucosa -- 53 Character of Bronchopulmonary Changes in Patients with Primary Ciliary Dyskinesia -- XII. Diagnosis, Treatment, and Prevention of Mucociliary -- 54 Genetic Counseling of Adults with Primary Ciliary Dyskinesia or Cystic Fibrosis -- XIII. Clinical Molecular Biology -- 55 Preliminary Exclusion of Chromosome 7 as a Potential Location of a Gene for Primary Ciliary Dyskinesia. , 56 Bend Shapes and Molecular Mechanisms of Flagella -- Index.