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  • 1
    Publication Date: 2016-06-03
    Description: Understanding telomere length maintenance mechanisms is central in cancer biology as their dysregulation is one of the hallmarks for immortalization of cancer cells. Important for this well-balanced control is the transcriptional regulation of the telomerase genes. We integrated Mixed Integer Linear Programming models into a comparative machine learning based approach to identify regulatory interactions that best explain the discrepancy of telomerase transcript levels in yeast mutants with deleted regulators showing aberrant telomere length, when compared to mutants with normal telomere length. We uncover novel regulators of telomerase expression, several of which affect histone levels or modifications. In particular, our results point to the transcription factors Sum1, Hst1 and Srb2 as being important for the regulation of EST1 transcription, and we validated the effect of Sum1 experimentally. We compiled our machine learning method leading to a user friendly package for R which can straightforwardly be applied to similar problems integrating gene regulator binding information and expression profiles of samples of e.g. different phenotypes, diseases or treatments.
    Keywords: Computational Methods, Genomics
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Orthopäde 26 (1997), S. 701-709 
    ISSN: 1433-0431
    Keywords: Key words Ergotherapy • Physiotherapy • Muscle transposition • Restore of muscle function • Plexus brachialis lesion ; Schlüsselwörter Krankengymnastik • Ergotherapie • Muskeltransferoperationen • Plexus-brachialis-Läsion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Nach Muskelersatzoperationen bei Plexusschäden sind sehr differenzierte Nachbehandlungsregime erforderlich, um für den Patienten bestmögliche Resultate zu erzielen. Dabei kommt es besonders auf die reibungslose interdisziplinäre Zusammenarbeit von Orthopäden/Chirurgen, Krankengymnasten, Ergotherapeuten, Orthopädietechnik und Krankenpflege an. Nur dann kann im Rahmen der postoperativen Rehabilitation die Funktionsstörung der betroffenen Extremität deutlich gebessert werden. Nachfolgend wird aus interdisziplinärer Sicht die differenzierte postoperative Nachbehandlung beim Deltaersatz durch Trapeziustransfer, bei der Arthrodese des Glenohumeralgelenks, beim Bizepsersatz durch den Transfer eines gestielten M. latissimus dorsi, bei der Proximalisierungsoperation der Handgelenkbeugemuskeln und bei Muskelersatzoperationen an der Hand erläutert.
    Notes: Summary Following augmentation of the upper extremity muscles necessitated by damage to the brachial plexus, special post-operative care programs are required to provide the patient with the best possible results. Proper care requires cooperation between the orthopedic surgeon, physical therapists and nurses. Only then can postoperative rehabilitation and functional control of the extremity improve. We describe interdisciplinary postoperative care programs for augmentation of the deltoid muscle with trapezius transfer, arthrodesis of the glenohumeral joint, biceps augmentation with the latissimus dorsi transfer, Steindler flexorplasty and augmentation of flexors/extensors muscles in the hand.
    Type of Medium: Electronic Resource
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