ISSN:
1439-6327
Keywords:
Alkalaemia
;
Lumbar fluid
;
$${\text{P}}_{{\text{O}}_{\text{2}} } $$ gradient
;
Oxygen affinity of haemoglobin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We investigated the effect of intravenous sodium bicarbonate (2 mmol·kg−1) on the arterial blood-spinal fluid $${\text{P}}_{{\text{O}}_{\text{2}} } $$ gradient in twelve anaesthetized hyperoxaemic human subjects who were in preparation for surgical procedures. The steady-state samples of arterial blood and lumbar fluid were withdrawn for the assessment of the acid-base status and electrolyte content in both fluid compartments before and after NaHCO3 injection. We found that NaHCO3 increased the arterial pH and $${\text{P}}_{{\text{CO}}_{\text{2}} } $$ , and decreased the blood-spinal fluid $${\text{P}}_{{\text{O}}_{\text{2}} } $$ gradient significantly. The latter was a result of an increase in spinal fluid $${\text{P}}_{{\text{O}}_{\text{2}} } $$ and a decrease in $${\text{Pa}}_{{\text{O}}_{\text{2}} } $$ . The diminished $${\text{P}}_{{\text{O}}_{\text{2}} } $$ gradient can be accounted for by the specific effect of carbamate and bicarbonate, distinct from that of pH, lowering the affinity of haemoglobin for oxygen. This might favor the maintenance of an adequate oxygen supply in the brain tissue under unfavorable conditions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00430226
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