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  • 1
    Online Resource
    Online Resource
    Dordrecht :Springer Netherlands,
    Keywords: Ionosphere. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (281 pages)
    Edition: 1st ed.
    ISBN: 9789400997639
    Series Statement: Geophysics and Astrophysics Monographs ; v.13
    Language: English
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  • 2
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (173 pages)
    Edition: 1st ed.
    ISBN: 9783318014594
    Series Statement: Medicine and Sport Science Series ; v.51
    DDC: 612.7/5
    Language: English
    Note: Cover -- Contents -- Preface -- Contributors -- Osteoporosis: A Pediatric Concern? -- Abstract -- Osteoporosis: The Size of the Problem -- A Growth and Development Issue? -- Factors Affecting Bone Mineral Acquisition -- Issues -- Conclusion -- References -- The Biomechanical Basis of Bone Strength Development during Growth -- Abstract -- Long Bone Strength: Material Composition and Structure -- Bone Material Composition -- Long Bone Structure -- Measuring Long Bone Strength -- Measuring Material Composition -- Measuring Bone Structural Strength -- Measures Combining Material and Structural Strength -- Long Bone Growth: Length, Size, Mass and Tissue Density -- Bone Length -- Bone Size and Geometry -- Bone Mass -- Bone Tissue Density -- Cortical Density -- Trabecular Density -- Bone Strength -- Regulation of Bone Strength Development -- Muscle Development and Bone Strength -- Hormonal Factors Regulating Bone Growth -- Longitudinal Bone Growth -- Bone Size -- Tissue Density -- Summary and Conclusions -- References -- The Effect of Exercise on Bone Mass and Structural Geometry during Growth -- Abstract -- The Effect of Exercise on Bone Mass, Geometry and Strength during Growth -- Effect of High-Impact Athletic Training on Bone Geometry and Strength during Growth -- Effect of Recreational and Leisure Activity on Bone Geometry and Strength during Growth -- Effect of School-Based Exercise Interventions on Bone Geometry and Strength -- Summary and Conclusion -- References -- Evidence for an Interaction between Exercise and Nutrition for Improved Bone Health during Growth -- Abstract -- Understanding the Terms 'Interaction ' or 'Effect Modification ' -- Combined Effect of Calcium, Vitamin D, or Protein and Exercise during Growth: Is There Evidence for an Interaction on Bone? -- Calcium -- Vitamin D -- Protein and Energy Intake -- Summary and Conclusion. , References -- Gene-Environment Interactions in the Skeletal Response to Nutrition and Exercise during Growth -- Abstract -- The Importance of Peak Bone Mass -- Genetics and Bone Mass and Strength -- Gene-Environment Interaction - Bone Response to Nutritional and Mechanical Factors during Growth -- Summary and Conclusion -- References -- The Effect of Energy Balance on Endocrine Function and Bone Health in Youth -- Abstract -- Description of Exercise-Associated Menstrual Cycle Disturbances -- Skeletal Parameters in Female Athletes with Menstrual Cycle Disturbances -- Bone Turnover in Women with Nutritionally Related Amenorrhoea -- Bone Turnover in Adolescents with Nutritionally Related Amenorrhoea -- Proposed Mechanisms of Disturbed Bone Turnover under Conditions of Energy Deprivation -- Reduced Synthesis and Action of Insulin-Like Growth Factor I in Energy Deprivation -- Insulin-Like Growth Factor I and Bone Turnover in Nutritionally Related Amenorrhoea -- Serum Leptin Concentration and Bone Metabolism -- Effect of Intense Training on Endocrine Function and Bone Health in Young Male Athletes -- Recommendations for the Prevention and Treatment of Low Bone Density in Female Athletes -- References -- Risk Factors for Fractures in Normally Active Children and Adolescents -- Abstract -- Epidemiology of Fractures during Growth -- Fracture Patterns Differ from Those of Adults -- Fracture Rates Vary with Age and Sex -- A Few Children Sustain Most of the Fractures -- Trauma Precipitates Fracture -- Childhood Fractures Are Becoming More Common -- Risk Factors for Fracture during Growth -- Children with Repeated Fractures Usually Fracture First at a Young Age -- Children Who Fracture Have Lower Bone Mass -- Musculoskeletal Weakness -- High Adiposity -- Medications with Toxic Actions on Bone -- Genetic Factors -- Intrauterine Factors -- Nutritional Factors. , Inadequate Dietary Calcium -- Calorie Deprivation -- Beverage Choices -- Milk Avoidance -- Cigarette Smoking -- Strategies for Preventing Fractures during Growth -- Creating a Safe Play and Sport Environment -- Limiting Risk-Taking Behavior -- Management of Low aBMD -- General Strategies to Reduce Fractures during Growth -- References -- Does Exercise during Growth Preve t Fractures in Later Life? -- Abstract -- The Fragility Fracture Problem -- Does Exercise during Growth Increase the Accrual of Bone Mass and Improve Bone Structure? -- Are Exercise-Induced Benefits to Areal Bone Mineral Density Retained following the Cessation of Training? -- Are Exercise-Induced Benefits in Bone Mass Preserved with Retirement? -- Are Exercise-Induced Structural Changes of the Skeleton Preserved with Retirement? -- Influence of Current Physical Activity and Detraining on Fracture Risk -- Summary and Conclusion -- References -- Lessons Learned from School-Based Skeletal Loading Intervention Trials: Putting Research into Pra tice -- Abstract -- Lesson 1: Exercise in Youth Confers Substantial Skeletal Benefit -- Lesson 2: Prepuberty and Early Puberty May Provide the Ideal 'Window of Opportunity' in Which to Intervene -- Lesson 3: Bone Responds to Specific Loading Characteristics -- Modality -- Intensity -- Frequency -- Duration -- Progression -- Lesson 4: Calcium Enhances the Effects of Exercise on the Young Skeleton -- Lesson 5: School-Based Exercise Interventions for Bone Health Are Feasible and Safe -- Tips to Delivering a Successful School-Based Intervention -- Conclusion -- Appendix: Example of Osteogenic Loading Activities, Progressions and a Circuit Program -- :Healthy Bones: Circuit Training -- Circuit Format -- References -- Subject Index.
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  • 3
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Replication of plasmid pAMβ1 is initiated by DNA polymerase I (Pol I) and completed by DNA polymerase III holoenzyme contained in the replisome machinery. In this study we report that initiation of DNA replication generates D-loop structures containing the nascent leading strand paired to its template, and that D-loop extension is arrested ≈230 bp from the initiation site of DNA synthesis in the presence of the plasmid-encoded resolvase. In vitro and in vivo data suggest that this arrest is caused by a collision between Pol I and the resolvase bound to its target. As the arrested D-loop replication intermediates carry a single-stranded primosome-assembly site, we hypothesize that the biological role of the replication arrest is to limit the region replicated by Pol I and to promote the replacement of Pol I by the replisome in order to initiate concerted synthesis of the leading and lagging strands.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 31 (1996), S. 0 
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Products of periodontopathic bacteria exert immunomodulatory effects on various lymphoid cell populations, some of which have been implicated in the pathogenesis of periodonthis. It has recently been suggested that some of these bacterial products may possess superantigenic (SAg) activity. SAg bind simultaneously to the Vβ chain of T cell receptors and to class II major histocompatibility complex molecules, thereby activating as many as 35% of T cells to proliferate and produce cytokines. In order to examine this question, the proliferation of splenic and thymic T cells from immunologically naive, 3-6-wk-old Balb/c (H-2d), C57BL/6 (H-2b) and C3H/HeJ (H-2k) mice was assessed in response to sonic extracts of periodontopathogens. Laboratory and/or reference strains of a.o. Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia and Prevotella nigrescens were used as stimulants. Staphylococcal enterotoxin B (SEB), a known superantigen, was utilized as a positive control. Unfractionated spleen cells responded to several of the tested preparations of the different bacteria, as well as to SEB, Con A and Escherichia coli LPS. Thymocytes responded to Con A and SEB, but not to LPS or to any sonic extract. Spleen cells depleted of B cells by panning responded to SEB and Con A, but not to LPS and showed a reduced response to sonicates. The residual response of B cell-depleted spleen cells was reduced essentially to background by treatment with anti-Thy 1.2 + C'. Similar results were obtained in the presence of 5% added mitomycin-treated antigen presenting cells, indicating that these cells were not limiting. These results demonstrate that extracts of periodontopathic bacteria do not stimulate murine T cells in a manner consistent with superantigenic activation.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of periodontal research 28 (1993), S. 0 
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: At present Actinobacillus actinomycetemcomitans is regarded as an important microorganism in the etiology of some forms of periodontitis. The purpose of the present investigation was to study the number of Restriction Endonuclease Analysis (REA)-types present in the oral cavity of A. actinomycetem-comitans positive subjects and to study the possibility of transmission of A. actinomycetemcomitans within families of adult periodontitis patients. DNA of A. actinomycetemcomitans isolates was digested with a combination of the restriction endonucleases Pst I and Bam HI, after which the DNA fragments were separated by agarose gelelectrophoresis. To study the number of REA-types, multiple A. actinomycetemcomitans isolates obtained from 8 different sites in the oral cavity of five subjects were typed. The results showed that in most cases only one REA-type is present. In the 13 families investigated in 4 of the 26 children (15%) and in 1 of the 13 spouses (8%) of the adult periodontitis patients an indistinguishable REA-type was found within the families. This suggests that also in the case of adult periodontitis transmission of A. actinomycetemcomitans is possible, but does not seem to occur easily.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard International Publishers
    Journal of periodontal research 36 (2001), S. 0 
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To explore aspects of cellular immune responses in the pathogenesis of periodontitis we analyzed phenotype and function of peripheral T cells. Two groups of subjects participated: one group consisted of 10 highly susceptible patients with severe periodontitis (mean age 29 years) and a control group consisted of 10 age, gender and race matched subjects with gingivitis. From all subjects peripheral blood was collected. The results showed that the numbers of CD3+, CD4+ and CD8+ T cells as well as the CD4/CD8 ratio, and the proliferative capacity of T cells, were not different between the two groups of subjects. Also, proportions of naive and memory T cells for both the CD4+ and CD8+ subpopulations were not different. Functional heterogeneity within the CD4+ and CD8+ T cell compartments was determined by intracellular analysis of interferon-γ(IFN-γ) and interleukin-4 (IL-4) production. On the basis of these latter analyses among CD4+ and CD8+ cells, T helper (Th) 1 or Th2 function and T cytotoxic (Tc) 1 or Tc2 function, respectively, could be deduced. No significant differences in proportions of CD4+ and CD8+ T cells positive for intracellular IFN-γ or IL-4 were observed between periodontitis patients and gingivitis controls; however a higher level of intracellular IL-4 in CD8+ T cells was seen in periodontitis patients. This might indicate that there is a shift towards a Tc2 function within the CD8+ T cell subpopulation. The current explorative study suggests that further research into the role of CD8+T cells in the pathogenesis of periodontitis is warranted.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Affective Disorders 28 (1993), S. 61-69 
    ISSN: 0165-0327
    Keywords: Depression ; Positive symptoms ; Schizophrenia
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Affective Disorders 1 (1979), S. 173-177 
    ISSN: 0165-0327
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Livestock Production Science 20 (1988), S. 119-134 
    ISSN: 0301-6226
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Livestock Production Science 8 (1981), S. 139-153 
    ISSN: 0301-6226
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
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