Note: Intro -- Contents -- Preface -- Multiple Genes Governing Biological Functions in the Genetic Backgrounds of LaboratoryMice and Asian Wild Mice -- Overview of Transgenic and Gene Knockout Mice -- Alkylation Carcinogenesis in Mice with Altered Levels of DNA Repair Methyltransferase -- Cancer Predisposition inMutantMice Defective in the XPC DNA Repair Gene -- Myeloid Leukemia: Disease Genes and MouseModels -- Genetic and Epigenetic Susceptibility to Endogenous Retrovirus-Induced Lymphomas in SL Mice -- Inheritance of Pulmonary Adenoma Susceptibility in Mice -- TSC2 GeneMutant (Eker) Rat Model of a Mendelian Dominantly Inherited Cancer -- Apc Gene KnockoutMice as a Model for Familial Adenomatous Polyposis -- A Rat Model System for Predisposition to Stomach Cancer -- Genetic and Hormonal Regulation of Murine Hepatocarcinogenesis -- Genetics of Skin Tumor Promotion -- The Genetic Components of Susceptibility to Breast Cancer in the Rat -- Author Index.

Note: Cover -- Contents -- Preface -- References -- Mammalian Transglutaminases: A Family Portrait -- Introduction -- Keratinocyte Transglutaminase (TGM1) -- Nomenclature -- Site of Expression -- Promoter -- Inducers and Suppressors -- TG1 Protein -- Functions -- Disease -- Accession Number -- Tissue Transglutaminase (TGM2) -- Nomenclature -- Site of Expression -- Promoter -- Inducers and Suppressors -- TG2 Protein -- Functions -- Disease -- Accession Number -- Epidermal Transglutaminase (TGM3) -- Nomenclature -- Site of Expression -- Promoter -- Inducers and Suppressors -- TG3 Protein -- Functions -- Disease -- Accession Number -- Transglutaminase 4 (TGM4) -- Nomenclature -- Site of Expression -- Promoter -- Inducers and Suppressors -- TG4 Protein -- Functions -- Disease -- Accession Number -- Transglutaminase 5 (TGM5) -- Nomenclature -- Site of Expression -- Promoter -- Inducers and Suppressors -- TG5 Protein -- Functions -- Disease -- Accession Number -- Transglutaminase 6 (TGM6) -- Nomenclature -- Site of expression -- TG6 Protein -- Functions -- Accession Number -- Transglutaminase 7 (TGM7) -- Nomenclature -- Site of Expression -- Promoter -- Accession Number -- Factor XIII A1 Subunit (F13A1) -- Nomenclature -- Site of Expression -- Promoter -- Inducers and Suppressors -- F13A1 Protein -- Functions -- Disease -- Accession Number -- Band 4.2 (EPB4.2) -- Nomenclature -- Site of Expression -- Band 4.2 Protein -- Functions -- Disease -- Accession Number -- Resources for TGs Research -- Anti-TG2 Antibodies -- A. Calbiochem -- B. Lab Vision -- C. Novus Biologicals -- Anti-TG3 Antibody -- Immundiagnostik -- Anti-TG5 Antibody -- Orbigen, Inc. -- Anti-Factor XIIIa -- Lab Vision -- Anti-Erythrocyte Membrane Protein Band 4.2 (EPB4.2) Antibody -- Orbigen, Inc. -- Anti-Isopeptide Antibody -- Novus Biologicals -- References. , Structure-Function Relationships of Transglutaminases - A Contemporary View -- The Inherent Chemical Reactivity of Carboxamido and Thiol Functional Groups in Proteins -- Waterproof Activated Cysteines Make Transglutaminases - In Theory -- The Genes and Expression of Human TGases -- Regulators of TGases -- Enigmatic Secretion of TGases -- The Solved TGases Structures -- TGase Domain Structure -- Structural Correlates of Transglutamination -- Activation of Latent TGases -- Purine Nucleotide Binding and Hydrolysis by TGases -- G-Protein Signaling by TGase 2 -- Disulfide Exchange and Regulation Through Thiol Modifications -- NonCatalytic Interactions of TGase 2 -- Concluding Remarks -- Acknowledgments -- References -- Transglutaminases and Their Substrates -- Introduction -- The Members of TGase's Family -- TGases Substrates -- Conclusions -- References -- Type 2 Transglutaminase and Cell Death -- 'Tissue' Transglutaminase or Type 2 -- Role of TG2 in Cellular Functions -- Effects of TG2 Deletion in Mice -- Is TG2 a Proapoptotic or Prosurvival Protein? -- Is TG2 Involved in Autophagy? -- TG2 and Cell Death in Pathological Settings -- Neurodegenerative Diseases -- Liver Pathologies -- Conclusions -- References -- Transglutaminase and Cell-Survival Signaling -- Introduction -- TGase-2 as a cross-linker enzyme -- TGase-2 Activates RhoA by Transamidation -- TGase-2 as G-Protein Signal Transducer -- TGase-2 as Cell-Survival Factor -- TGase-2 Is Activated under Stressing Conditions -- TGase-2 as Inducer of Neuronal Differentiation -- References -- Transglutaminases in Wound Healing and Inflammation -- Introduction -- Cutaneous Wound Healing -- Role of Transglutaminases in Skin Morphogenesis and Cutaneous Wound Healing -- Genetically Modified Mice for Investigating the Role of Transglutaminases in Wound Healing. , General Role of TG2 in Cell-Matrix Interactions Significant in Wound Repair -- Multiple Activities and Regulation of TG2 -- Externalization of TG2 during Cell Stress and TG2-Associated Cell Death -- Role of TG2 in Matrix Synthesis and Degradation -- Matrix Structural Role of TG2 -- Role of TG2 in Cell Migration -- Role of TG2 in the Inflammatory Response -- TG2 and Activation of Phospholipase A2 -- TG2 and Inflammatory Conditions -- Wound Healing and Fibrosis in the Kidney -- Aberrant Wound Healing in the Kidney Leading to Progressive Renal Scarring -- The Role of TG2 in Wound Healing and Scarring in the Kidney -- TG2 in Progressive Renal Scarring -- Dual Approach to Transglutaminase-Based Wound Repair: Transglutaminase as a Novel Molecular Target and as a Biocatalyst for Tissue Engineering -- Conclusions -- Acknowledgments -- References -- Transglutaminases in Epidermis -- Introduction -- Epidermal Differentiation -- Keratinocyte Transglutaminases -- Transglutaminase Type 1 -- Regulation of TG1 Level and Activity -- Transglutaminase Type 3 -- Transglutaminase Type 5 -- Transglutaminases in Skin Disease -- Transglutaminase Function in Epidermis -- Acknowledgments -- References -- Tissue Transglutaminase (TG2) in Cancer Biology -- Introduction -- TG2 as Antiapoptotic Factor -- The Connection between TG2, Drug Resistance and Metastasis -- TG2 Expression in Drug-Resistant Cells -- TG2 Expression in Metastatic Cancer Cells -- TG2 and Integrin-Mediated Signaling -- TG2 and Carcinogenesis -- Conclusion -- References -- Transglutaminases in Neurodegenerative Disorders -- Introduction -- TGs in Development of the Nervous System -- TGs in Neuronal Apoptosis -- TGs in Neurodegeneration -- Huntingtont's Disease -- Alzheimert's Disease -- Parkinsont's Disease -- Amyotrophic Lateral Sclerosis -- Injury of the Nervous System -- Conclusions -- References. , Tissue Transglutaminase and Celiac Disease -- General Concepts on Celiac Disease -- The Discovery that Tissue Transglutaminase is the Main Autoantigen in CD: New Tool for CD Diagnosis -- tTG is Upregulated and Catalitically Active in CD Intestinal Mucosa -- tTG Deamidating Activity Can Trigger Immune Response to Gliadin -- Substrate Specificity of tTG Towards Gluten Peptides -- tTG Transamidating Activity Seems to be Responsible for Autoimmunity in CD -- Potential Role of Anti-tTG Antibodies in CD Pathogenesis -- Conclusions -- References -- Transglutaminases as Biotechnological Tools -- Biomedicine -- Cosmetics -- Food -- Seafood Products -- Meat Products -- Dairy Products -- Soy Products -- Cereal-Based Products -- Edible Films -- Nutritional Aspects of TGase-cross-linked Proteins -- Leather and Textile Industries -- Analytical Biotechnology Applications -- Other Applications -- Conclusions -- References -- Extracellular Transglutaminase: Factor XIII -- Introduction -- Gene and Expression of Factor XIII -- Structure of Factor XIII -- Sushi Domains in Factor XIIIB -- Functions of Factor XIII -- TGase-Related Diseases -- Factor XIII-Related Diseases -- Polymorphisms of Factor XIII and Thrombosis -- Clinical Features of Congenital Factor XIII Deficiency -- Molecular Defects in Congenital Factor XIII Deficiency -- Animal Model of Factor XIII Deficiency -- Factor XIII Replacement Therapy -- References -- Transglutaminases of Lower Organisms -- Introduction -- TGs and Their Homologs Involved in Protein Cross-Linking -- TG in Growth and Development -- Gene Sequence Analysis of TGs -- Amino Acid Residues Involved in Transamidation Activity of Thioredoxins and PDIs -- Conclusion -- Acknowledgments -- References -- Transglutaminases of Higher, Lower Plants and Fungi -- Introduction -- Possible Roles of Plant TGases. , Structural Role in Cytoskeleton and Cell Wall -- TGases in Chloroplasts -- TGases in Programmed Cell Death -- Light Sensitivity of TGase in Higher Plants -- Light and Salt Stress Effects on TGase Activity in Algae -- Plant and Animal TGases Recognize Each Other's Substrates -- The First Plant TGase -- The First Mammalian-Type TGase of Slime Molds -- Biotechnological Aspects -- Acknowledgments -- References -- Author Index -- Subject Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- P -- R -- S -- T -- W -- Y.

Note: Förderkennzeichen BMBF 01BE17018A-B , Verbundnummer 01183314 , Sprache der Kurzfassungen: Deutsch, Englisch