GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Document type
Keywords
Publisher
Years
  • 1
    Electronic Resource
    Electronic Resource
    Cytokines in the induction and expression of T-cell-mediated granuloma formation and protection in the murine model of listeriosis (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 158 (1997), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: Lymphocyte-mediated inflammation is a hallmark of autoimmune diseases, such as multiple sclerosis, Crohn's disease, rheumatoid arthritis and sarcoidosis. However, this type of inflammation probably developed under evolutionary pressure from pathogenic microorganisms, such as mycobacteria and other intracellular infective agents. One such pathogen, the gram-positive bacterium Listeria monocytogenes (L. monocytogenes), induces a cascade of tissue alterations that ultimately results in the eradication of the bacteria associated with a granulomatous response. Consequently, murine listeriosis has been established as a model to analyze not only T-cell-dependent antibacterial protection but also T-cell-mediated mononuclear inflammation in parenchymal organs. Extensive studies of the molecular basis of the latter phenomenon led to the conclusion that the most decisive step from non-specific microabscess formation to granulomatous inflammation is the activation of non-specifically invading CD4+ T cells, which results in high local concentrations of TNF-α and IFN-γ in the presence of IL-2. This in turn induces CD11b-independent mechanisms of intraparenchymal monocyte accumulation. Because any attempt to neutralize the effects of TNF-α and IFN-γ to modulate T-cell-mediated inflammation will also dramatically decrease host resistance, other anti-inflammatory strategies based on the modulation of TNF-α and IFN-γ-induced mechanisms of monocyte accumulation must be developed. Recalling the classical work by Dienes & Schoenheit on the induction d bacterial allergies (1), the cytokine phenotype of granuloma formation also has implications as regards the most potent adjuvant environment for the development of a T-cell response. The murine listeriosis model is the basis for all conclusions in this article on the role of cytokines in the induction and expression of T-cell-mediated inflammation and. as we will show, promises to yield still more insights into the rational design of vaccines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1997.tb00994.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Tailoring host immune responses to Listeria by manipulation of virulence genes – the interface between innate and acquired immunity (2003)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 35 (2003), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Although attenuated strains of microbial pathogens have triggered vaccine development from its origin, the role of virulence factors in determining host immunity has remained largely unexplored. Using the murine listeriosis model, we investigated whether the induction and expansion of protective and inflammatory T cell responses may be modified by selective manipulation of virulence genes. We intentionally deleted specific genes of Listeria monocytogenes, including those encoding the positive regulatory factor (prfA), hemolysin (hly), the actin nucleator (actA), and phospholipase B (plcB). The resulting strains showed decisive differences in their immunogenic properties. In particular, we identified a double-deletion mutant that retained Listeria's profound ability to induce protective CD8+ T cells, but that is strongly attenuated and exhibits a significantly reduced ability to induce CD4+ T cell-mediated inflammation. We conclude that this mutant, L. monocytogenesΔactAΔplcB, is at present the most promising mutant for a bacterial vaccine vector and is able to safely induce potent CD8+ T cell-mediated immunity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0928-8244(02)00469-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Genetic Engineering in Agriculture: Who Stands to Benefit? (2000)
    Springer
    Journal of agricultural and environmental ethics 13 (2000), S. 313-327 
    Details
    ISSN: 1573-322X
    Keywords: Agri-biotech companies ; agriculture ; biotechnology ; existing technologies ; farmers ; farm crisis ; genetic engineering ; hunger ; poverty ; productivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Philosophy
    Notes: Abstract The use of genetic engineering inagriculture has been the source of much debate. Todate, arguments have focused most strongly on thepotential human health risks, the flow of geneticmaterial to related species, and ecologicalconsequences. Little attention appears to have beengiven to a more fundamental concern, namely, who willbe the beneficiaries of this technology? Given the prevalence of chronic hunger and thestark economics of farming, it is arguable thatfarmers and the hungry should be the mainbeneficiaries of agricultural research. However, theapplication of genetic engineering appears unlikely tobenefit either of these two groups. This technology islargely controlled by the private sector, and itscontinued development hinges on its profitability.Thus, the only likely beneficiaries of the applicationof genetic engineering in agriculture are companieswith the capacity to use it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009551609832
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Untersuchungen zur Trockendispergierung im Partikelgrößenbereich um 1 μm (1993)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 65 (1993), S. 728-733 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330650612
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Monitoring genomic alterations with a panel of oligonucleotide probes specific for various simple repeat motifs (1991)
    Weinheim : Wiley-Blackwell
    Electrophoresis 12 (1991), S. 186-192 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Germline and somatic instability of the human genome was studied, using synthetic oligonucletides specific for simple repeat motifs. The following probes were used: (GTG)5, (GACA)4, (GATA)4, (CT)8, (TTAGGG)3, (GT)8, (GAA)6 and (GGAT)4. Each of them is unique with respect to the target regions recognized in the genome. Thus compilation of the various fingerprint data provides a complex map of the genome (and its deviations). While the fingerprints of differentiated somatic tissues never showed any alterations, in tumor tissues (namely gliomas) many changes could be detected. Most of the latter reflect secondary karyological aberrations. In nearly one third of the gliomas, drastically amplified and apparently monomorphic DNA fragments were identified. This marker should make it possible to deal with causal pathogenetic mechanisms as well as novel diagnostic strategies.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150120215
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Determining consanguinity by oligonucleotide fingerprinting with (GTG)5/(CAC)5 (1991)
    Weinheim : Wiley-Blackwell
    Electrophoresis 12 (1991), S. 397-402 
    Details
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Simple tandemly organized (GTG)n/(CAC)n sequences are spread throughout the human chromosomes. The most informative DNA fingerprints for the testing of pedigrees and/or paternity were obtained with the simple triplet repeat probe (GTG)5 or its complement (CAC)5. These hypervariable simple-repeat fragments are stably inherited in a Mendelian fashion. Using these highly discriminating probes, all human individuals could, theoretically, be differentiated, except for genetically identical monozygotic twins. Examples from actual case work are reported and pertinent advantages of this methodology are discussed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150120603
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    facet.materialart.
    Unknown
    Whole rock major and chalcophile element composition as well as measurments of standard materials from samples at the Niuatahi caldera (Table S4) (2022)
    PANGAEA
    Details
    Publication Date: 2023-04-24
    Keywords: #436; #439; #440; Aluminium oxide; Antimony; Arsenic; Barium; Bismuth; Cadmium; Calcium oxide; Cobalt; Copper; Elevation of event; Event label; hydrothermal deep sea vents; ICP-MS; in-situ mineral geochemistry; Iron oxide, total; Latitude of event; Lead; Longitude of event; Magnesium oxide; Manganese oxide; Material; Molybdenum; Nickel; Pb isotopes; Phosphorus pentoxide; Potassium oxide; Remote operated vehicle; ROV; Sample code/label; Selenium; Silicon dioxide; SO263; SO263_069; SO263_071; SO263_082; SO263_097; SO263_103; Sodium oxide; Sonne_2; Sulfur isotopes; Television-Grab; Tellurium; Thallium; Titanium dioxide; Tonga Rift; TVG; X-ray fluorescence (XRF); Zinc
    Type: Dataset
    Format: text/tab-separated-values, 112 data points
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    DATA PANGAEA
  • 8
    facet.materialart.
    Unknown
    In-situ mineral, bulk sulfide-sulfate, S- and Pb isotope, and whole rock major and chalcophile element data from the submarine Niuatahi hydrothermal system, Lau basin, Tonga rear-arc (2022)
    PANGAEA
    Details
    Publication Date: 2023-01-13
    Description: The samples used in this study were recovered from active hydrothermal venting at the seafloor at the Niuatahi caldera, Lau basin, Tonga rear-arc, observed during research cruise SO263. The dataset was collected in order to define the magmatic and hydrothermal processes leading to spatially selective trace element enrichment within submarine caldera-hosted black smoker systems. The in-situ data was measured by electron probe micro analyzer and laser ablation inductively coupled mass spectrometry. The sulfur- and Pb isotope composition of hydrothermal sulfide separates were analysed by a Flash EA IsoLink elemental analyzer interfaced to a ThermoScientific Delta V Advantage isotope ratio mass spectrometer and a a Thermo-Fisher Neptune Plus multicollector inductively coupled mass spectrometer, respectively. Bulk sulfide-sulfate composition was determined by an Agilent 735 inductively coupled mass spectrometer, inductively coupled optical emission spectroscopy and instrumental neutron activation analysis. The whole rock/glass major and chalcophile element contents were measured by a Spectro XEPOS He-x-ray fluorescences spectrometer, a JEOL JXA-8200 Superprobe electron probe micro analyzer, a Thermo Fisher Scientific X-Series 2 quadrupole inductively coupled mass spectrometer, and a PSA Millenium Excalibur 10.055 continuous flow hydride-generation atomic fluorescence spectrometer. All analyses except the bulk sulfide-sulfate and S isotope measurements were carried out at the GeoZentrum Nordbayern, Friedrich-Alexander University, Germany, which were measured at Activation Labs in Ontario, Canada, and the Westfälische Wilhelms-University, Münster, Germany, respectively. The dataset gives a detailed insight into the magmatic and hydrothermal evolution and processes controlling seafloor black-smoker-style mineralization.
    Keywords: hydrothermal deep sea vents; in-situ mineral geochemistry; Pb isotopes; Sulfur isotopes
    Type: Dataset
    Format: application/zip, 8 datasets
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    DATA PANGAEA
  • 9
    facet.materialart.
    Unknown
    Chemistry of seafloor samples from the Niuatahi caldera (Table S1) (2022)
    PANGAEA
    Details
    Publication Date: 2023-03-03
    Keywords: #435; #436; #437; #439; #440; #441; Antimony; Arsenic; Barium; Bismuth; Cadmium; Cobalt; Copper; CS; Elevation of event; Event label; FUS-Na2O2; Gold; hydrothermal deep sea vents; in-situ mineral geochemistry; Instrumental neutron activation analysis (INAA); Iron; Latitude of event; Lead; Longitude of event; Manganese; Mercury; Molybdenum; MULT INAA / TD-ICP; Nickel; Pb isotopes; Remote operated vehicle; ROV; Sample code/label; Sample type; Selenium; Silver; SO263; SO263_068; SO263_070; SO263_082; SO263_090; SO263_097; SO263_103; SO263_110; Sonne_2; Sulfur; Sulfur isotopes; TD-ICP; Television-Grab; Tonga Rift; TVG; Vanadium; Zinc
    Type: Dataset
    Format: text/tab-separated-values, 416 data points
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    DATA PANGAEA
  • 10
    facet.materialart.
    Unknown
    Rock XRD measurments of seafloor samples from the Niuatahi caldera (Table S1) (2022)
    PANGAEA
    Details
    Publication Date: 2023-03-03
    Keywords: Alunite; Anhydrite; Cristobalite; Gypsum; hydrothermal deep sea vents; in-situ mineral geochemistry; Pb isotopes; Pyrite, FeS2; Pyrophyllite; Sample code/label; Sanidine; SO263; SO263_069; Sonne_2; Sulfur; Sulfur isotopes; Television-Grab; Tonga Rift; TVG; X-ray diffraction (XRD)
    Type: Dataset
    Format: text/tab-separated-values, 9 data points
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    DATA PANGAEA
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...