ISSN:
1432-0533
Keywords:
Minimata Disease
;
CNS Degenerative Disorder
;
Mercury Poisoning
;
Focal Demyelination
;
Electron Microscopy
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A case of suspected mercury poisoning (Minamata disease) was studied. Microscopic and ultrastructural changes in the nervous system were compared with those of a confirmed case of mercury poisoning from Minamata Bay, Japan, and those from exprimental animals intoxicated with methyl mercury. Disintegration of the granular layer, disappearance of the Purkinje cells with Bergmann's fiber proliferation and demyelination of the fiber tracts were observed in the cerebellum. Ultrastructural examination also revelad extensive proliferation of astrocytic fibers and characteristic focal demyelination and loosening of the myelin sheaths in many nerve fibers. Such pathological changes were consistent with those observed in both human cases and experimental animals poisoned by methyl mercury.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00688076
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