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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 593 (1990), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2307
    Keywords: E-cadherin ; Colon ; Adenoma ; Carcinoma ; Tumour grade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have used an avidin-biotin immunoperoxidase technique to localise epithelial cadherin (E-cadherin), a calcium-dependent cell-cell adhesion molecule, in 107 paraffin-embedded sections from 93 patients consisting of 24 with colorectal adenoma, 55 with rectal carcinoma and 14 with liver metastases. The corresponding primary colorectal tumours were also studied in these cases. E-cadherin was expressed by normal colorectal epithelial cells with typical membranous staining at the intercellular junctions. Loss of normal membranous E-cadherin expression and presence of cytoplasmic staining were found frequently in adenomas larger than 1 cm (P〈0.01), with high grade dysplasia and villous histology (P〈0.01). In primary rectal cancers, loss of membranous expression correlated with high tumour grade. No correlation was seen with Dukes and Jass stage, local extramural spread and 5-year recurrence rate. Complete loss of membranous E-cadherin immunoreactivity was seen in 7/14 (50%) liver metastases in which 6/7 (86%) showed intense membranous E-cadherin immunoreactivity in the corresponding primary tumour. Our data indicate that changes in E-cadherin immunoreactivity and cellular localisation correlate with size, severe dysplasia in adenomas and tumour grade in carcinomas. However, there seems to be no correlation between loss of membranous E-cadherin immunoreactivity and the invasive and metastatic potential of the carcinomas.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2013-01-05
    Description: [1]  It is well known that the Ionian Sea is characterized by thin (8–11 km) crystalline crust, thick (5–7 km) sedimentary cover, and low heat flow, typical for a Mesozoic (at least) basin. Yet seismic data have not yielded univocal interpretations, and a debate has developed on the oceanic versus “thinned continental” nature of the Ionian basin. Here we analyze the magnetic anomaly pattern of the Ionian Sea and compare it to synthetic fields produced by a geopotential field generator, considering realistic crust geometry. The Ionian basin is mostly characterized by slightly negative magnetic residuals and by a prominent positive (150 nT at sea level) “B” anomaly at the northwestern basin margin. We first test continental crust models, considering a homogeneous crystalline crust with K = 1 × 10 −3 , then a 5 km thick deep crustal layer of serpentinite (K = 1 × 10 −1 ). The first model yields insignificant anomalies, while the second gives an anomaly pattern anticorrelated with the observed residuals. We subsequently test oceanic crust models, considering a 2 km thick 2A basaltic layer with K = 5 × 10 −3 , magnetic remanence of 5 A/m, and a unique magnetic polarity (no typical oceanic magnetic anomaly stripes are apparent in the observed data set). Magnetic remanence directions were derived from Pangean-African paleopoles in the 290–190 Ma age window. Only reverse polarity models reproduce the B anomaly, and among them the 220–230 Ma models best approximate magnetic features observed on the abyssal plain and at the western basin boundary. The Ionian Sea turns out to be the oldest preserved oceanic floor known so far.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
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