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  • 1
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The study was performed to investigate the different effects of ketanserin and urapidil on haemodynamics, kidney function and plasma catecholamine and aldosterone levels. Forty male patients scheduled for myocardial revascularisation were assigned at random to two groups: group K received ketanserin, group U received urapidil. Anaesthesia consisted of fentanyl, flunitrazepam and pancuronium. Haemodynamic variables were evaluated at eight predefined time points of the operation. Creatinine and free-water clearance as well as plasma levels of adrenaline, noradrenaline and aldosterone were measured in three different periods of the operation. While the groups showed no clinically relevant differences in the haemodynamic variables and the hormone plasma concentrations, the creatinine clearance in group K was slightly increased in the period after cardiopulmonary bypass. Both ketanserin and urapidil prevented hypertension even in the presence of elevated catecholamine plasma levels during and after cardiopulmonary bypass.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 44 (1995), S. 818-825 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Anästhesie ; On-line Monitoring ; Automatische Datenerfassung ; Artefakte ; Key words Anaesthesia ; On-line monitoring ; Automated record-keeping ; Artifacts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Increasing numbers of monitors at the anaesthesiologist's workplace, providing more than 20 different parameters of the patient's condition, have already made it impossible to record all the values in a handwritten form. Consequently, this most common method of record-keeping must be incomplete and inaccurate. In recent years computerised data-acquisition systems have been introduced into clinical practice in order to produce more reliable records. But after a 7-year experience in the use of such a system in cardiac anaesthesia, we have recognised certain problems that remain to be solved before automated record-keeping will achieve wider acceptance. The first is the handling problem, which was discussed in a previous paper [11]. The second major problem is the appearance of artifacts, caused mainly by mechanical manipulations during the operation. In this paper, 300 courses of anaesthesia that were recorded on-line during different cardiac surgery procedures were examined and the incidence as well as the kind of artifacts occurring were evaluated. Algorithms were developed for each haemodynamic parameter to suppress these artifacts automatically by a subsequent analysing process; the efficiency of that “artifact filter” was validated in 35 of the 300 cases. Based on more than 30,000 values for each parameter, the incidence of artifacts was 3%–7%. However, only 0.1%–0.5% of the artifacts could not be eliminated by the filter. The method described here provided acceptable graphic printouts of the most important haemodynamic parameters (Figs. 1b and 2b) and would also be suitable to serve as an input filter for automatically running anaesthesia data-examination processes, which are currently being developed in our clinic.
    Notes: Zusammenfassung Die on-line Aufzeichnung von Monitordaten ist zukünftig wahrscheinlich das einzige Verfahren, die Vielzahl der intraoperativ anfallenden Daten suffizient zu protokollieren. Allerdings sind nach eigenen Erfahrungen noch Schwachpunkte zu beseitigen, bevor solche computergestützten Systeme im Routinebetrieb zufriedenstellend eingesetzt werden können. Neben den Verbesserungen der Benutzerführung, auf die an anderer Stelle näher eingegangen worden ist [11], stellt vor allem das Auftreten von Meßartefakten ein wichtiges, bisher ungelöstes Problem dar. In dieser Arbeit wurden anhand von 300 Narkosen aus dem kardioanästhesiologischen Bereich der Universität Kiel Art und Häufigkeit der bei der on-line Protokollierung aufgetretenen Meßfehler untersucht. Es wurden Korrekturalgorithmen entwickelt, mit deren Hilfe eine automatische Artefaktunterdrückung durchgeführt werden konnte. Die Effizienz dieses „Artefaktfilters“ wurde bei 35 ausgewählten Narkoseverläufen mit insgesamt über 30000 registrierten Einzelwerten pro Meßparameter überprüft. Das hier beschriebene Verfahren stellt erstmals eine Methode zur nachträglichen automatischen Eliminierung von Meßartefakten bei on-line erfaßten Monitordaten dar.
    Type of Medium: Electronic Resource
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