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  • 1
    Electronic Resource
    Electronic Resource
    In vitro chemosensitivity testing in the treatment of ovarian carcinoma (1989)
    Springer
    Archives of gynecology and obstetrics 246 (1989), S. 227-231 
    Details
    ISSN: 1432-0711
    Keywords: Chemosensitivity, short-term assay ; Ovarian carcinomas ; Relapse-free interval
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In vitro chemosensitivity to cisplatinum, adriamycin, cyclophosphamide, and 5-fluorouracil was investigated in 58 cases of ovarian carcinoma using Volm's short-term test. These in vitro results were retrospectively correlated with the relapse-free interval. Operative treatment in all patients (FIGO stage I (5), III (43), IV (10)) comprised maximum debulking procedure including hysterectomy, adnexectomy, omentectomy, pelvic and in most cases additionally paraaortic lymphadenectomy. Subsequently, all patients were treated with the cisplatinum-epirubicin-cyclophosphamide regimen. 33/58 tumors (66%) were sensitive in vitro (inhibition of nucleic acid precursor incorporation of more than 45% as compared to untreated controls). The median relapse-free interval of patients with sensitive tumors was significantly longer than that of those with resistant carcinomas (30.3 versus 22.6 months, respectively;P〈0.05). Histopathological evaluation showed the majority of serous cystadenocarcinomas to be sensitive (26/33=79%,P〈0.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00934523
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Amniotic fluid insulin levels in nondiabetic pregnant women: an update (1998)
    Springer
    Archives of gynecology and obstetrics 262 (1998), S. 81-86 
    Details
    ISSN: 1432-0711
    Keywords: Key words: Amniotic fluid insulin ; Normal range ; Nondiabetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Elevated amniotic fluid insulin levels in diabetes are frequently described but there are few systematic data on metabolically healthy women to define normal ranges. Previous studies had too high normal ranges because they were based on unspecific insulin binding radioimmunoassays. The aim of the study was to update normal amniotic fluid insulin data and to define a reliable normal range in the course of a nondiabetic pregnancy. Amniotic fluid insulin levels were measured in 841 amniotic fluid samples of 707 nondiabetic women undergoing amniocentesis for hydramnios, suspected malformation, determination of lung maturation, Rhesus antibodies and cordocentesis. Mean (±SD) of amniotic fluid insulin level was 3.6 (±2.1) μU/mL at 31.5 (±4.9) weeks of pregnancy. The 97th percentile was 8.2 μU/mL. Insulin levels show a biphasic course between 16th and 42nd weeks of pregnancy with a zenith at 30th week. Only two cases (0.3%) had unexplicably elevated amniotic fluid insulin levels ≥10 μU/mL. Thus, in nondiabetic women amniotic fluid insulin levels 〉10 μU/mL are unlikely.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004040050232
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    Paper (German National Licenses)
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