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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 1147-1147 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] For our experiments we used intact white rats and rats with alloxan diabetes weighing 100-120 gm. The animals were killed after 16 hours fasting and a slice of about 50 mgm. of epididymal fat was incubated for four hours in 4 ml. of pooled post-absorptive human serum at 37 C. with constant ...
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 185 (1960), S. 926-927 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Immediately after killing the animal we removed the fat of the epididymis, froze it by means of liquid air, ground it to a fine powder from which we removed the fat in the cold, using acetone and ether, and afterwards dried it. The homogeneous powder was extracted with a solution of ammonia, pPL 8 ...
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  • 3
    ISSN: 0009-8981
    Keywords: Diabetic retinopathy ; Microalbuminuria ; N-acetyl-β-Glucosaminidase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Clinica Chimica Acta 5 (1960), S. 90-94 
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Clinica Chimica Acta 6 (1961), S. 846-850 
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Clinica Chimica Acta 4 (1959), S. 691-693 
    ISSN: 0009-8981
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 20 (1981), S. 129-133 
    ISSN: 1432-0428
    Keywords: Amylase isoenzymes ; serum amylase ; urine amylase ; insulin dependent diabetes ; non-insulin dependent diabetes ; exocrine and endocrine pancreatic function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have evaluated the relationship between diabetes mellitus and exocrine pancreatic insufficiency in diabetic subjects by measuring a specific isoamylase arising from the pancreas. The pancreatic- and salivary-type isoamylase activity in serum and urine were evaluated and related to duration of disease, sex, age, weight, blood glucose level and glycosuria in 153 diabetics. In the insulin-dependent diabetics diagnosed between 15 and 24 years of age, a significant decrease in pancreatic isoamylase activity was found in serum and urine (means with 2 SD range, 50 U/l, 19–137 U/l, and 47 U/l, 4–607 U/l, respectively), as compared with control subjects (79 U/l, 45–140 U/l, and 183 U/l, 43–789 U/l, respectively). In this group of patients a low stimulated output of amylase into the duodenum was also observed (mean with range, 537 U, 87–1808 U), compared with controls (the lower limit of normal 2183 U). A significant positive correlation was found between stimulated output of amylase into the duodenum and pancreatic isoamylase activity in serum (r = 0.84, p 〈 0.01). In the non-insulin dependent diabetics, a significant negative correlation was found between blood glucose levels and pancreatic isoamylase activity in serum (r = -0.46, p 〈 0.01). In the diet-treated non-insulin dependent diabetics the pancreatic isoamylase activity in serum was increased compared with controls (mean and 2 SD range, 102 U/l, 49–211 U/l). In patients with blood glucose level above 12 mmol/l, however, a lowered pancreatic isoamylase activity in serum, and no apparent rise in serum immunoreactive insulin in glucose loading test was observed. The results suggest that production of pancreatic amylase is related to endocrine pancreatic function in diabetes mellitus.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 36 (1989), S. 199-201 
    ISSN: 1432-1041
    Keywords: diazoxide ; insulinoma ; euglycaemic clamping
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The use of diazoxide in patients with insulinoma has been evaluated using the euglycaemic clamp technique. There was significantly reduced mean tissue sensitivity to insulin, expressed as the ratio of glucose disposal rate to serum insulin concentration (M/I), in untreated patients compared to the control group. The metabolic clearance rate of insulin (MCRI) was reduced in the patients before treatment in comparison with the controls. The administration of diazoxide (Proglicem) for three days (3 mg·kg−1 per day) caused a fall in serum insulin concentrations, together with an increase in the metabolic clearance rate of insulin and increased tissue sensitivity to insulin.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of wildlife research 18 (1972), S. 6-15 
    ISSN: 1439-0574
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary Caged wild boar in Květov were examined in the course of a year to study the epizootology of the stomach nematodes named above. The results were based on dissections, discharge of eggs and invasions of intermediate hosts. Peak egg discharges were found for both nematodes in the months December to January, in April, and from August to September. Boar were invaded most frequently in late summer and in spring. Larvae of both nematodes were found in almost every stage of development in coprophagous beetles. Ascarops larvae were found in the following beetles:Geotrupes stercorarius (84,6%),G. stercorosus, aberr. monticola (Heer.) (44.0%),G. vernalis (37.5%) andAphodius sticticus Panz. (1.28%). Larvae ofPhysocephalus sexalatus were found in the following beetles:G. stercorarius L. (26.49%) andG. stercorosus, aberr. monticola (Heer.) (9.09%). Larvae in the II. and III. stages of development wintered in the beetles. During the summer months larvae of the II. stage were found to be in the majority in the intemediate hosts.
    Abstract: Résumé On a étudié l'épizootologie des Nématodes stomacaux Ascarops strongylina (Rud.) et Physocephalus sexalatus (Molin) au moyen d'autopsies helminthologiques, de la dynamique de l'expulsion des oeufs et de l'élimination des hôtes intermédiaires tout au long de l'année. Des pics d'expulsion d'oeufs ont été observés chez les deux Nématodes de décembre à janvier, en avril et d'août à septembre. L'invasion chez le Sanglier s'observe surtout à la fin de l'été et au printemps. Des larves de coléoptères coprophages à presque tous les stades de développement ont été trouvées chez les deux espèces de Nématodes: des larves d'Ascarops ont été observées chez Geotrupes stercorarius (84,6%), chez G. stercorosus, aberr. monticola (Heer.) (44,0%), G. vernalis (37,5%) et Aphodius sticticus Panz. (1,28%); des larves de Physocephalus sexatatus ont été observées chez G. stercorarius L. (26,49%) et G. stercorosus aberr. monticola (Heer) (9,09%). Les larves des 2èmes et 3èmes stades hivernent dans ces coléoptères. Au cours des mois d'été les larves du 2ème stade dominent dans les hôtes intermédiaires.
    Notes: Zusammenfassung Beim Schwarzwild im Wildgatter Květov wurde die Epizootologie der MagennematodenAscarops strongylina (Rud.) undPhysocephalus sexalatus (Molin) mit Hilfe helminthologischer Untersuchungen, Feststellungen der Eierausscheidungsdynamik und Invasion der Zwischenwirte im Verlauf des Jahres untersucht. Bei den Nematoden wurden drei Höhepunkte der Eierausscheidung, und zwar von Dezember bis Januar, im April und im August bis September festgestellt. Zu Invasionen beim Schwarzwild kommt es vor allem im Spätsommer und im Frühjahr, bei koprophagen Käfern fanden sich zu dieser Zeit Larven fast aller Entwicklungsstadien der beiden Nematoden. Ascarops-Larven wurden in den KäfernGeotrupes stercorarius (84,6%),G. stercorosus, aberr, monticola (Heer.) (44,0%),G. vernalis (37,5%) undAphodius sticticus Panz. (1,28%) festgestellt. Larven vonPhysocephalus sexalatus wurden in den KäfernG. stercorarius L. (26,49%) undG. stercorosus, aberr. monticola (Heer.) (9,09%) nachgewiesen. Die Larven des II. und III. Stadiums überwinterten in den Käfern. Während der Sommermonate überwogen in den Zwischenwirten die Larven des II. Stadiums.
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  • 10
    Publication Date: 2018-04-27
    Description: DS-2969b is a novel GyrB inhibitor in development for the treatment of Clostridium difficile infection (CDI). The aim of this study was to assess the safety, tolerability, pharmacokinetics, and effects on the normal gastrointestinal microbiota of multiple daily oral ascending doses of DS-2969b in healthy subjects. The study enrolled three sequential ascending-dose cohorts (60 mg, 200 mg, and 400 mg). In each cohort, subjects received an oral dose of DS-2969b or placebo (six subjects received DS-2969b, and two received placebo) each morning for 14 days. DS-2969b was safe and well tolerated at all dose levels examined. All adverse events related to DS-2969b were mild and predominantly related to the gastrointestinal tract. DS-2969a (free form of DS-2969b) plasma concentrations increased with increasing doses; however, both the maximum concentration of drug in serum ( C max ) and the area under the concentration-time curve (AUC) increased less than dose proportionally. In all cohorts, sufficient fecal levels of DS-2969a were achieved within 24 h following the administration of the first dose and maintained for at least 17 days. Following treatment with DS-2969b, clear reductions in the populations of Clostridium coccoides and Bifidobacterium groups were observed. However, populations of three other bacterial groups examined ( Bacteroides fragilis , Clostridium leptum , and Prevotella ) were not affected. Data from this study support and encourage the further development of DS-2969b as a novel treatment for CDI.
    Print ISSN: 0066-4804
    Electronic ISSN: 1098-6596
    Topics: Biology , Medicine
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