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  • 1
    Electronic Resource
    Electronic Resource
    The influence of the size of acute ischaemic myocardial lesions on coronary reserve and left ventricular function in the dog (1977)
    Springer
    Basic research in cardiology 72 (1977), S. 402-410 
    Details
    ISSN: 1435-1803
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 10 Hunden werden durch periphere Ligaturen im Bereich des R. descendens der linken Koronararterie Ischämiebezirke von 5,1±1,4% bzw. 15,7±2,5% des linksventrikulären Myokards erzeugt. Unter maximaler Koronardilatation (0,4 mg/kg Dipyridamol) und konstantem Aortendruck vermindern sich erst bei Ischämiebezirken von 15,7% des linksventrikulären Myokards die Flußraten im R. descendens um 50% (p〈0.05), im R. circumflexus um 36% (p〈0,01) und die Gesamtmyokarddurchblutung (Argon-Methode) um 44% (p〈0,02). Die Parameter der linksventrikulären Funktion dp/dtmax und Vmax vermindern sich um 26 bzw. 27% (p〈0,02). Bei Messung der regionalen Durchblutung (133Xenon) werden auch kleinere Ischämiebezirke 5,1% des linksventrikulären Myokards) erfaßt. Die direkt mit der Argon-Methode ermittelte Myokarddurchblutung zeigt eine gute Übereinstimmung mit den elektromagnetisch gemessenen Flußraten (r=0,957).
    Notes: Summary Acute ischaemic lesions of 5 and 15% of the left ventricular mass were produced in 10 dogs by ligations of branches of the left anterior descending coronary artery. Under maximal coronary dilatation by Dipyridamole and at constant aortic pressure, an ischaemic lesion of 15% caused reductions of blood flow in the left anterior descending coronary artery of 50% (p〈0.05), the R. circumflexus of 36% and of total myocardial blood flow (Argon method) by 44% (p〈0.02). Parameters of left ventricular function, dp/dtmax and Vmax fell by 26 and 27% respectively (p〈0.02). Ischaemic lesions of 5% LV mass were detected by 133 Xenon clearance estimations, but had no effect on any of the other variables measured. There was good agreement between estimations of total myocardial blood flow (Argon) and direct measurement of coronary flow with electromagnetic flowmeters (r=0.957).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02023599
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  • 2
    Electronic Resource
    Electronic Resource
    Coronardurchblutung und Coronarreserve im hämorrhagischen Schock (1972)
    Springer
    Research in experimental medicine 157 (1972), S. 271-273 
    Details
    ISSN: 1433-8580
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851165
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  • 3
    Electronic Resource
    Electronic Resource
    Fatty acid composition of adipose tissue, blood lipids, and glucose tolerance in patients with different degrees of angiographically documented coronary arteriosclerosis (1982)
    Springer
    Research in experimental medicine 180 (1982), S. 161-168 
    Details
    ISSN: 1433-8580
    Keywords: Adipose fatty acids ; Blood lipids ; Glucose tolerance ; Coronary angiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-eight patients with symptoms of angina pectoris were studied for adipose tissue fatty acid composition and cardiovascular risk factors while hospitalized for selective coronary angiography. Patients with manifest diabetes mellitus and deviations from the “normal” customary diet were excluded. Pairwise comparison between the groups with absent, slight, moderate, and severe coronary arteriosclerosis showed reasonable comparability for age, relative body weight, and skinfold measurements. The proportion of smokers, but not of hypertensives, showed a significant positive relationship with the degree of arteriosclerosis. Serum cholesterol was similar in all four groups, while triglycerides were clearly, but not significantly (P〉0.05) higher in patients with coronary arteriosclerosis. The oral glucose tolerance test (OGTT) index was significantly higher in moderate and severe disease. Significantly higher proportions for palmitic acid and lower proportions for linoleic acid were also found in these two groups. Multiple linear regression analysis showed a positive association with coronary arteriosclerosis for: OGTT index 〉 palmitic acid 〉 arachidonic acid 〉 triglycerides. The close negative association between the proportion of stearic acid in adipose tissue and coronary heart disease observed in two previous studies could not be confirmed. On the basis of the present study, stearic acid correlates with age rather than with arteriosclerotic disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851055
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of acute vagally-mediated bradycardia on systemic hemodynamics and coronary blood flow before and after coronary stenosis (1983)
    Springer
    Basic research in cardiology 78 (1983), S. 85-98 
    Details
    ISSN: 1435-1803
    Keywords: heart rate ; bradycardia ; coronary blood flow ; tension-time index ; coronary constriction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirkung kurzdauernder (1 min) vagusinduzierter Bradykardien wurde in 9 anästhesierten Hunden untersucht. Vor und nach abgestufter Koronarstenose des Ramus interventricularis anterior (LAD) und des Ramus circumflexus (CCA) der linken Koronararterie wurde vagal gereizt und atrial stimuliert (120 und 80/min). Bei Vorliegen einer 90%-LAD-Stenose bewirkte eine Bradykardie in der Tendenz eine Änderung des erhöhten LAD-Koronarwiderstands (CVR-LAD) und des reduzierten CVR-CCA zu den Kontrollwerten hin, die bei entsprechend langsamen Herzfrequenzen in Abwesenheit einer Koronarstenose ermittelt wurden. Daraus folgte, daß der LAD-Koronarfluß (F-LAD) relativ weniger abnahm und der sich daraus ergebende Anstieg des F-CCA verschwand. Bei gleichzeitigem Vorliegen einer 90%-LAD-und einer 70%-CCA-Stenose waren die Auswirkungen der Bradykardie ähnlich denjenigen, die bei einer einzelnen 90%-LAD-Stenose beobachtet wurden; dagegen war der zusätzliche Fluß durch die CCA aufgehoben. Daher bestand keine signifikante Differenz zwischen den frequenzabhängigen Änderungen des CVR-CCA und F-LAD im Vergleich zu den in Abwesenheit von Koronarstenosen beobachteten Änderungen. Bei Vorliegen einzelner oder kombinierter Koronarstenosen führt eine Bradykardie zu einer Umkehrung der Abnahme des Aortendrucks und des Herzminutenvolumens in Richtung der Kontrollwerte bei vergleichbar langsamen Frequenzen vor Koronarstenose. Die Ergebnisse unterstützen die Vorstellung, daß bei 90%-LAD-Stenose vagusinduzierte Bradykardie 1. den Spannungs-Zeit-Index (myokardialer Nährstoffbedarf) vermindert und damit die Herzleistung in Richtung Flußarbeit verschiebt und 2. den antegraden Fluß durch die hochgradig stenosierte LAD erleichtert und damit den zusätzlichen Fluß durch die nichtstenosierte CCA verhindert.
    Notes: Summary The effects of short episodes (1 min) of vagally-mediated bradycardia were studied in 9 anesthetized dogs utilizing vagal stimulation and slow atrial pacing (120 and 80 beats/min) before and after graded coronary constriction of the left anterior descending (LAD) and the left circumflex (CCA). In the presence of 90% LAD stenosis, bradycardia tended to restore both the elevated total LAD coronary vascular resistance (CVR-LAD) and the reduced, total CVR-CCA towards control levels obtained at corresponding slow rates in the absence of coronary stenosis; as a result, LAD coronary flow (F-LAD) was relatively less reduced and the accessory rise of F-CCA disappeared. In the presence of combination of 90% LAD plus 70% CCA stenosis, the effects of bradycardia on total CVR-LAD and F-LAD were similar to those obtained with single 90% LAD stenosis, but the accessory flow through the CCA was abolished resulting in no significant difference of the rate-dependent alterations of total CVR-CCA and F-CCA as compared with those observed in the absence of coronary stenosis. In the presence of single or combined coronary stenosis, bradycardia restored the depressed aortic pressure and cardiac output towards control values obtained at comparable slow rates before coronary stenosis. The results support the concept that in the presence of 90% LAD stenosis vagally-mediated bradycardia 1) decreases the tension-time index (myocardial nutritional demand) shifting cardiac performance to less expensive “flow work” and 2) facilitates antegrade flow through the highly stenotic LAD thereby inhibiting accessory flow through the nonstenotic CCA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923196
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