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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 242 (1995), S. 195-202 
    ISSN: 1432-1459
    Keywords: Medullary syndrome ; Magnetic resonance imaging ; Brainstem infarction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract There are two major vascular syndromes of the medulla oblongata: the medial and the lateral. The medial medullary syndrome is characterized by the triad of ipsilateral hypoglossal nerve palsy with contralateral hemiparesis and loss of deep sensation. Lateral medullary infarction commonly presents with Homer's syndrome, ataxia, alternating thermoanalgesia, nystagmus, vertigo and hoarseness. Combinations of the two major syndromes occur as bilateral medial medullary, hemi-medullary and bilateral lateral medullary syndromes. Each of these syndromes frequently manifests with incomplete or atypical findings depending on the extent of the lesion. Magnetic resonance imaging has been useful in the clinical diagnosis of medullary infarctions. The site of the lesion may help predict the arteries involved.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurology 236 (1989), S. 430-431 
    ISSN: 1432-1459
    Keywords: Cluster headache ; Carotid artery ; Nasopharyngeal carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cluster headache is generally not associated with recognised disease, and the pathogenesis remains unclear. The onset of typical cluster headaches is reported in a patient with nasopharyngeal carcinoma. The tumor encircled the internal carotid artery but did not extend intracranially. It thus appears possible that cluster headaches may be triggered by processes involving the carotid artery.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2014-03-20
    Description: On 3 January 2014 the results of a year long investigation by the US Centers for Disease Control (CDC) into an outbreak of New Delhi metallo-β-lactamase (NDM)-producing carbapenem resistant...
    Keywords: Endoscopy, Infectious diseases, US, Surgical diagnostic tests, Cardiothoracic surgery, Gastrointestinal surgery, General surgery
    Topics: Medicine
    Published by BMJ Publishing Group
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  • 4
    Publication Date: 2018-11-16
    Description: Purpose: Because of emergence of resistance to osimertinib, a third-generation EGFR tyrosine kinase inhibitor (TKI), no targeted treatments are available for patients with lung cancer who lose sensitivity due to new mutations or bypass mechanisms. We examined in animals and in vitro an alternative therapeutic approach making use of antibodies. Experimental Design: An osimertinib-sensitive animal model of lung cancer, which rapidly develops drug resistance, has been employed. To overcome compensatory hyperactivation of ERK, which we previously reported, an anti-EGFR antibody (cetuximab) was combined with other antibodies, as well as with a subtherapeutic dose of osimertinib, and cancer cell apoptosis was assayed. Results: Our animal studies identified a combination of three clinically approved drugs, cetuximab, trastuzumab (an anti-HER2 mAb), and osimertinib (low dose), as an effective and long-lasting treatment that is able to prevent onset of resistance to osimertinib. A continuous schedule of concurrent treatment was sufficient for effective tumor inhibition and for prevention of relapses. Studies employing cultured cells and analyses of tumor extracts indicated that the combination of two mAbs and a subtherapeutic TKI dose sorted EGFR and HER2 for degradation; cooperatively enhanced apoptosis; inhibited activation of ERK; and reduced abundance of several bypass proteins, namely MET, AXL, and HER3. Conclusions: Our in vitro assays and animal studies identified an effective combination of clinically approved drugs that might overcome resistance to irreversible TKIs in clinical settings. The results we present attribute the long-lasting effect of the drug combination to simultaneous blockade of several well-characterized mechanisms of drug resistance. Clin Cancer Res; 24(22); 5610–21. ©2018 AACR . See related commentary by Fan and Yu, p. 5499
    Print ISSN: 1078-0432
    Electronic ISSN: 1557-3265
    Topics: Medicine
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  • 5
    Publication Date: 2012-10-10
    Description: We report here the first structure of double helical arabino nucleic acid (ANA), the C2'-stereoisomer of RNA, and the 2'-fluoro-ANA analogue (2'F-ANA). A chimeric dodecamer based on the Dickerson sequence, containing a contiguous central segment of arabino nucleotides, flanked by two 2'-deoxy-2'F-ANA wings was studied. Our data show that this chimeric oligonucleotide can adopt two different structures of comparable thermal stabilities. One structure is a monomeric hairpin in which the stem is formed by base paired 2'F-ANA nucleotides and the loop by unpaired ANA nucleotides. The second structure is a bimolecular duplex, with all the nucleotides (2'F-ANA and ANA) forming Watson–Crick base pairs. The duplex structure is canonical B-form, with all arabinoses adopting a pure C2'-endo conformation. In the ANA:ANA segment, steric interactions involving the 2'-OH substituent provoke slight changes in the glycosidic angles and, therefore, in the ANA:ANA base pair geometry. These distortions are not present in the 2'F-ANA:2'F-ANA regions of the duplex, where the –OH substituent is replaced by a smaller fluorine atom. 2'F-ANA nucleotides adopt the C2'-endo sugar pucker and fit very well into the geometry of B-form duplex, allowing for favourable 2'F···H8 interactions. This interaction shares many features of pseudo-hydrogen bonds previously observed in 2'F-ANA:RNA hybrids and in single 2'F-ANA nucleotides.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 6
    Publication Date: 2014-11-27
    Description: Coexistence of KRAS mutation with mutant but not wild-type EGFR predicts response to tyrosine-kinase inhibitors in human lung cancer British Journal of Cancer 111, 2203 (25 November 2014). doi:10.1038/bjc.2014.401 Authors: A Choughule, R Sharma, V Trivedi, A Thavamani, V Noronha, A Joshi, S Desai, P Chandrani, P Sundaram, S Utture, N Jambhekar, S Gupta, J Aich, K Prabhash & A Dutt
    Print ISSN: 0007-0920
    Electronic ISSN: 1532-1827
    Topics: Medicine
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  • 7
    Publication Date: 2016-01-23
    Description: Commentary on : Bewtra M , Newcomb CW, Wu Q, et al .. Mortality associated with medical therapy versus elective colectomy in ulcerative colitis: a cohort study. Ann Intern Med 2015 ; 163 : 262 –70. Context The management of patients with moderate to severe ulcerative colitis (UC) is challenging, and the definition of successful treatment is unclear. Clinical practice is moving from symptomatic improvement to mucosal healing as this has shown to result in longer clinical remission, lower rates of hospitalisation and reduced need for surgery. 1 Surgical management is reserved for patients refractory to medical therapy or in those that develop colorectal neoplasia. This study aims to assess whether patients with severe UC have improved survival after elective colectomy compared to those being treated with certain immunosuppressive therapies. Methods A retrospective matched cohort study was conducted by searching the Medicare/Medicaid database in all 50 states from 2000 to 2011 for...
    Keywords: Inflammatory bowel disease, Health policy, Clinical trials (epidemiology), Epidemiologic studies, Immunology (including allergy), Other anaesthesia, Health economics, Health service research
    Print ISSN: 1356-5524
    Electronic ISSN: 1473-6810
    Topics: Medicine
    Published by BMJ Publishing Group
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  • 8
    Publication Date: 2020-02-12
    Description: The Last Glacial–Interglacial Transition (LGIT; 15,000–11,000 cal BP) was characterized by complex spatiotemporal patterns of climate change, with numerous studies requiring accurate chronological control to decipher leads from lags in global paleoclimatic, paleoenvironmental, and archaeological records. However, close scrutiny of the few available tree-ring chronologies and radiocarbon-dated sequences composing the IntCal13 14C calibration curve indicates significant weakness in 14C calibration across key periods of the LGIT. Here, we present a decadally resolved atmospheric 14C record derived from New Zealand kauri spanning the Lateglacial from ~13,100–11,365 cal BP. Two floating kauri 14C time series, curve-matched to IntCal13, serve as a 14C backbone through the Younger Dryas. The floating Northern Hemisphere (NH) 14C data sets derived from the YD-B and Central European Lateglacial Master tree-ring series are matched against the new kauri data, forming a robust NH 14C time series to ~14,200 cal BP. Our results show that IntCal13 is questionable from ~12,200–11,900 cal BP and the ~10,400 BP 14C plateau is approximately 5 decades too short. The new kauri record and repositioned NH pine 14C series offer a refinement of the international 14C calibration curves IntCal13 and SHCal13, providing increased confidence in the correlation of global paleorecords.
    Type: info:eu-repo/semantics/article
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  • 9
    Publication Date: 2020-02-12
    Language: English
    Type: info:eu-repo/semantics/article
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  • 10
    Publication Date: 2020-02-12
    Description: The Greenland Stadial 1 (GS-1; ~12.9 to 11.65 kyr cal BP) was a period of North Atlantic cooling, thought to have been initiated by North America fresh water runoff that caused a sustained reduction of North Atlantic Meridional Overturning Circulation (AMOC), resulting in an antiphase temperature response between the hemispheres (the ‘bipolar seesaw’). Here we exploit sub-fossil New Zealand kauri trees to report the first securely dated, decadally-resolved atmospheric radiocarbon (14C) record spanning GS-1. By precisely aligning Southern and Northern Hemisphere tree-ring 14C records with marine 14C sequences we document two relatively short periods of AMOC collapse during the stadial, at ~12,920-12,640 cal BP and 12,050-11,900 cal BP. In addition, our data show that the interhemispheric atmospheric 14C offset was close to zero prior to GS-1, before reaching ‘near-modern’ values at ~12,660 cal BP, consistent with synchronous recovery of overturning in both hemispheres and increased Southern Ocean ventilation. Hence, sustained North Atlantic cooling across GS-1 was not driven by a prolonged AMOC reduction but probably due to an equatorward migration of the Polar Front, reducing the advection of southwesterly air masses to high latitudes. Our findings suggest opposing hemispheric temperature trends were driven by atmospheric teleconnections, rather than AMOC changes.
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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