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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing AG,
    Keywords: Human behavior-Endocrine aspects. ; Neuroendocrinology. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (463 pages)
    Edition: 1st ed.
    ISBN: 9783031129704
    DDC: 612.8
    Language: English
    Note: Intro -- Foreword -- Contents -- Contributors -- 1: Arnold Adolph Berthold -- References -- 2: Frank Lillie -- Childhood and Family History -- Education and Family Life -- A Distinguished Career -- Research Overview -- Marine Embryology -- Chick Embryology and Sexual Differentiation -- Freemartinism -- Brown Leghorn Sexual Differentiation -- Involvement in the Eugenic Society -- Conclusion -- References -- 3: Calvin Perry Stone -- References -- 4: Josephine Ball -- References -- 5: William Caldwell Young -- References -- 6: Dorothy Price -- References -- 7: Frank A. Beach -- References -- 8: Arnold A. Gerall -- References -- 9: Roger A. Gorski -- References -- 10: Robert W. Goy -- Goy's Early Career -- Phoenix, Goy, Gerall, and Young, 1959 and Beyond -- Monkey Studies and the Move to the Oregon Regional Primate Research Center -- The Organizational Hypothesis and the Ramstergig -- Director Wisconsin Regional Primate Research Center -- Other Contributions to Behavioral Neuroendocrinology -- Editor of Hormones and Behavior -- The Aromatization Hypothesis -- Masculinization, Defeminization, and Bisexuality -- Socialization and Sex Differences in Social Behavior -- Timing of Androgen Exposure and Separation of Effects on Genitalia and Behavior -- References -- 11: Charles H. Phoenix -- References -- 12: Daniel Sanford Lehrman -- Background of this Historical Biography -- Lehrman Legends -- Legend: Lehrman's Attitudes to Grades and Requirements -- Legend: Lehrman's Amazing Lecturing and Speaking Abilities -- Lehrman's Mermaid and Minotaur -- Legendary Lehrman Meals -- Legend: Lehrman Offered Freedom to Others -- Lehrman's Legendary Loyalty -- Lehrman's Scientific Contributions -- Neural and Neuroendocrine Basis of Reproductive Behavior -- Learning -- Motivation -- Current Status of Issues Addressed by Lehrman -- Lasting Aspects of Lehrman's Work. , Standing on the Shoulders of Giants -- References -- 13: Jay S. Rosenblatt -- Introduction -- Three Faces -- The Painter -- The Analyst -- The Scientist -- Professional and Personal Recognition and Appreciation -- References -- 14: Peter Robert Marler -- References -- 15: Julian M. Davidson -- Early Years -- Academics -- Behavioral Neuroendocrinology: Rodents -- Behavioral Neuroendocrinology: Humans and Hyenas -- References -- 16: Stephen E. Glickman -- Early Influences and Education -- Junior Professorships -- Life and Professorship in Berkeley -- Establishing the Berkeley Hyena Project: A Collaborative Network for an "Experiment of Nature" -- The Ontogeny of Sex Differences in Spotted Hyenas -- Identifying the Mechanisms of Sex Differences in Unusual Species -- Colony Closure -- Service and Teaching -- Other Contributions -- References -- 17: Mary F. Dallman -- Introduction -- Glucocorticoid Negative Feedback -- Facilitation of Stress Responses -- Metabolic Interactions with the Stress Axis -- Other Major Contributions -- Conclusions -- References -- 18: Benjamin D. Sachs -- Sachs' Early Years -- Preparation for Graduate School? -- Graduate and Postgraduate Years -- Not Sold in Storrs -- The Making of a Fondateur (or Slaying the Dragon) -- You Can't Be a Carpenter Without a Hammer -- Penile Responses and Copulation -- Organic Versus Psychogenic Erections -- Conclusions: A Scholar's Life -- References -- 19: Ronald J. Barfield -- References -- 20: Lynwood George Clemens -- In the Beginning -- Organizational Effects of Gonadal Hormones -- Activational Effects of Gonadal Hormones on Sexual Behavior -- Advancing the Field Through Networking and Mentoring -- Conclusion -- References -- 21: Bruce S. McEwen -- Early Life and Scientific Foundations -- Understanding How Adrenal and Gonadal Hormones Can Impact the Brain. , The Impact of the Environment on the Brain -- Long-Term Consequences of Early Childhood Experiences -- Conclusions -- References -- 22: Donald W. Pfaff -- References -- 23: Eberhard Gwinner -- Circannual Research -- Photoperiodic and Circadian Contributions to Annual Timing -- Comparative Studies of Photoperiodism and Annual Cycles -- Extending the Scope of Annual Physiology: Hormones, Metabolism, and Cognition -- Circadian Research and Melatonin -- A Visionary of Inclusive Leadership -- A Lasting Legacy: Clocks in a Changing World -- References -- 24: Irving Zucker -- McGill University (1957-1961) -- University of Chicago (1961-1964) -- Oregon (1964-1966) -- Berkeley (1966-2022) -- References -- 25: Bruce D. Goldman -- References -- 26: Norman Adler -- References -- 27: Mei-Fang Cheng -- References -- 28: Ingeborg L. Ward -- Introduction -- Perinatal Exposure to Steroid Hormones Modifying Later Behavioral Potential -- Prenatal Stress and Hormonal Surges -- The Ward Lab -- References -- 29: Rae Silver -- Stewardship and Advocacy -- References -- 30: Michael J. Baum -- Early Years -- Graduate Years (1965-1970) -- The Dutch Years (1970-1977) -- Back to the USA -- Reflex Ovulation: Ancient History? -- Abandoning the Ferrets and Hopping on the Mouse Bandwagon -- Other Important Accomplishments -- Conclusion -- References -- 31: C. Sue Carter -- Early Life, Education, and Training -- Institutions, Promotions, and Leadership Positions -- Scientific Impact and Key Contributions to the Field of Behavioral Neuroendocrinology -- A Family of Accomplished Academicians and Professionals -- Conclusion -- References -- 32: Elizabeth Adkins-Regan -- References -- 33: Arthur P. Arnold -- Early Years -- Education -- Career -- Mid-Career Transformation -- Teaching and Mentoring -- Honors -- The Present and Future -- References -- 34: Alison Sarah Fleming. , Experiential and Hormonal Changes -- Early Life Experiences -- Summary -- References -- 35: David Crews -- Early History -- Research -- Nature's Own Experiments -- Neural Regulation of Sexual Behavior: Serendipity Favors the Prepared Mind -- Behavioral Neuroendocrinology: Pursuit of Novelty -- Temperature-Dependent Sex Determination: Questions, Not Species -- Transgenerational Epigenetics: How the Past Can Influence the Future -- Achievements, Awards, and Accomplishments -- References -- 36: Martha K. McClintock -- The Roots of Creativity and Curiosity -- Doctorate and Norman Adler at the University of Pennsylvania -- From Doctorate to Residency -- Faculty Appointment at the University of Chicago -- Becoming a Teacher -- Changing the Landscape of Neuroscience Through Collaborations and Architecture -- Institute for Mind and Biology at the University of Chicago -- Center for Interdisciplinary Health Disparities Research (CIHDR) -- Menstrual Synchrony, Mate Choice, and Vasanas -- Olfaction and Aging -- Epilogue -- References -- 37: Kim Wallen -- Effects of Social/Environmental Context on Adult Female Sexual Behavior: Activational Effects on Estrogens -- Effects of Social Context on Sex Differences in Behavior: Organizational Effects of Androgens -- Recent Research Contributions to Behavioral Neuroendocrinology -- Conclusion -- References -- 38: John Charteris Wingfield -- The Challenge Hypothesis -- Regulation of Seasonal Breeding -- Coping with a Capricious Environment: The Emergency Life-History Stage -- Conclusion -- References -- 39: Jacques Balthazart -- References -- 40: Andrew Howard Bass -- References -- 41: Judith M. Stern -- Early Life and Education -- Rutgers' Institute of Animal Behavior: Hormonal Control of Ring Dove Reproduction -- Postdoc at Stanford University: Postpartum Stress and Developmental Psychobiology. , Independent Research Career and Professional Struggles -- Sensory Regulation of Maternal Behavior -- Conclusion -- References -- 42: Hidden Gems in Neuroendocrinology and Behavior -- Introduction -- Percy Lavon Julian (Fig. 42.1) -- Education and Early Career -- Later Life -- Impact on the Field -- Lilian Burwell Lewis (Fig. 42.2) -- Eleanor Lutia Ison-Franklin (Fig. 42.3) -- Education and Early Career -- Later Life -- Impacts on the Field -- Ruth Smith Lloyd (Fig. 42.4) -- Education and Early Career -- Later Life -- Impacts on the Field -- Robert W Harris III (Fig. 42.5) -- The Powerful Role of Stress Hormones -- Education and Early Career -- Later in Life -- Impact on the Field: The Powerful Role of the Stress Hormones -- Antonio Alberto Nuñez (Fig. 42.6) -- Early Career -- Later in Life/Impacts on the Field -- Gregory Florant -- What to Do When It Gets Cold: A Seasonal Solution -- Education and Early Career -- Later in Life -- Impact on the Field -- Barrier Breakers -- Historical Roles for Black Colleges and Universities -- Societal Restraints on Jobs and Research Funding -- Stony the Road We Trod: To a Brighter Future -- References -- Index.
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  • 2
    Online Resource
    Online Resource
    Newark :John Wiley & Sons, Incorporated,
    Keywords: Neuropsychology. ; Psychology, Comparative. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (770 pages)
    Edition: 2nd ed.
    ISBN: 9781118285466
    DDC: 612.8
    Language: English
    Note: Intro -- Handbook of Psychology -- Contents -- Handbook of Psychology Preface -- Volume Preface -- Contributors -- Chapter 1 Behavioral Genetics -- Introduction -- Subjects -- Genome Projects -- Methods -- Natural Genetic Variants and Behavior -- Gene Mutations and Behavior -- Translational Knockdowns and Behavior -- Gene Expression Correlates With Behavior -- Genetics and Behavioral Taxonomy -- Male Mouse Aggression -- Mouse Emotionality -- Rat and Mouse Learning and Cognition -- Human Psychopathology -- Summary -- Genetics and Biological Mechanisms of Behavior -- Pedigree of Causes -- Mouse Olfaction -- Rodent Social Recognition -- Individual Chemosignals and Social Recognition -- Mouse Offense -- Summary -- Genotype by Genotype Interactions -- Mouse Emotionality -- Summary -- Genes, Environment, and Behavioral Development -- Rats Cognition -- Mouse Aggression -- Human Personality and Psychopathology -- Epigenetics -- Future Directions -- References -- Chapter 2 Evolutionary Psychology -- Levels Of Explanation in Evolutionary Psychology -- The Metatheory Level of Analysis -- Metatheoretical Assumptions that are Consensually Held by Evolutionary Scientists -- Natural Selection -- Adaptation -- Sexual Selection -- Inclusive Fitness Theory -- Special Metatheoretical Assumptions of Evolutionary Psychology -- Psychological Mechanisms as the Main Unit of Analysis -- Domain Specificity of Psychological Mechanisms -- The Environment of Evolutionary Adaptedness -- The Middle-Level Theory Level of Analysis -- Parental Investment Theory -- Good Genes Sexual Selection Theory -- The Hypothesis Level of Analysis -- Good Genes Sexual Selection Theory: Hypotheses -- The Prediction Level of Analysis -- Good Genes Sexual Selection Theory: Predictions -- The Future of Evolutionary Psychology -- The Impact of Evolutionary Psychology -- Future Directions. , References -- Chapter 3 Comparative Vision -- Environments and Eyes -- Fundamental Features of Photic Environments -- Eyes: Basic Design Features and Evolution -- Photosensitivity -- Measuring Animal Vision -- Three Issues in Comparative Vision -- Detecting Change -- Resolving Spatial Structure -- Exploiting Chromatic Cues -- Conclusion -- References -- Chapter 4 Visual Processing in the Primate Brain -- Visual Processing Basics -- Parallel Processing in Vision -- The Retina -- Photoreceptors -- Bipolar Cells -- Amacrine Cells -- Ganglion Cells -- Optic Nerve -- Lateral Geniculate Nucleus (LGN) -- Nonretinal Inputs to LGN -- Visual Areas in Primate Cerebral Cortex -- Visual Topographic Maps -- V1-Primary Visual Cortex -- V2 -- Major Cortical Visual Processing Pathways -- Ventral Pathway -- Position Tolerance -- Form Selectivity in Single Neurons -- Category Selectivity in fMRI -- Dorsal Pathway -- Middle Temporal Area (MT) -- Lateral Intraparietal Area (LIP) -- Concluding Remarks -- References -- Chapter 5 Comparative Audition -- Introduction -- Overview of Acoustic Stimuli and Their Transmission Through the Environment -- Auditory Function and Behavior -- Absolute Auditory Thresholds -- Masked Auditory Thresholds -- Frequency Difference Limens -- Temporal Resolution -- Localization -- Auditory Scene Analysis: From Psychoacoustics to Ethology -- Auditory Periphery -- Invertebrates -- Bony Fish -- Frogs -- Reptiles -- Birds -- Mammals -- Central Auditory Pathways -- Insects -- Fishes -- Frogs (Anurans) -- Reptiles -- Birds -- Mammals -- Summary and Future Directions -- References -- Chapter 6 Auditory Processing in Primate Brains -- Introduction -- From Sound to a Neural Code: The Functions of the External, Middle, and Inner EAR -- Auditory Structures of the Brainstem: Extracting Information from the Auditory Afferents -- The Superior Colliculus. , The Auditory Thalamus: The Distribution of Auditory Information to the Neocortex -- Cortical Auditory Areas and Networks in Primates -- The First Stage of Auditory Processing in Cortex: The Auditory Core -- The Second Stage of Cortical Processing: The Auditory Belt -- Higher Levels of Auditory and Multisensory Cortical Processing: The Parabelt and Beyond -- The Role of Frontal Cortex in Auditory Processing -- The Multisensory Region of the Upper Bank of the Superior Temporal Sulcus -- Auditory Projections to Visual Cortex and Visual Activation of Auditory Cortex -- Pathways for Auditory Memory -- Speech and Language -- References -- Chapter 7 Comparative Locomotor Systems -- Introduction and History -- Understanding "The Act of Progression": Historical Aspects -- The Neural Basis of Locomotor Pattern Generation: A First Concept -- Toward a Concept of Central Control of Locomotion -- The Concept of a Central Pattern Generation (CPG) -- Construction Principles of Pattern-Generating Networks for Locomotion -- Construction Principles of Pattern-Generating Networks for Locomotion -- Reciprocal Inhibition -- Forward Excitation and Reciprocal Inhibition -- Location of Pattern-Generating Networks for Locomotion -- Sensory Signals Controlling Locomotor Activity -- Visual Regulation of Locomotion -- Proprioceptive Regulation of Locomotion -- The Proprioceptive Control of Phase Transition -- The Regulation of the Magnitude of Muscle Activity -- The Role of Exteroceptive Input -- Sources of Neuromodulators -- Effects of Neuromodulators on the Output of Locomotor Networks -- Initiation of Locomotor Activity -- Modulation of Ongoing Locomotor Activity -- Receptors Classes That Modulate Locomotion -- Constitutive Receptor Activity -- Neuromodulators Affect Cellular Properties and the Synaptic Efficacy of Network Neurons. , Alteration of Intrinsic Cellular Properties of Network Neurons -- Alteration of Synaptic Transmission Between Network Neurons -- Plasticity in Motor Systems -- Injury-Induced Plasticity of Central Pattern-Generating Networks -- Plasticity in Afferent Pathways Controlling Locomotion -- Injury-Induced Plasticity of Descending Tracts -- Conclusions -- References -- Chapter 8 Neural Mechanisms of Tactile Perception -- Overview -- Peripheral Neural Mechanisms of Tactile Perception -- Cutaneous Mechanoreception -- Proprioception -- Summary of the Peripheral Afferent Inputs -- Central Mechanisms of form and Texture Perception -- Ascending and Central Pathways Related to Form and Texture Perception -- Form and Texture Perception -- Representation of Stimulus Curvature -- Processing of Spatial Form in SII Cortex -- Neural Mechanisms of Motion Perception -- Neural Mechanism of Global Shape Processing -- Flutter, Vibration, and Texture Perception With a Probe -- Mechanisms of Attention in Touch -- The Focus of Attention -- Attention Effects on Tactile Neural Responses -- Neural Coding of Selective Attention -- Summary -- References -- Chapter 9 The Biopsychology of Pain -- Introduction -- The Peripheral Nervous System -- Primary Afferent Fibers -- Inflammation and Peripheral Sensitization -- Specific Receptors and Ion Channels in Primary Afferent Fibers -- Phenotypic Changes During Chronic Pain -- The Sympathetic Nervous System -- The Spinal Cord Dorsal Horn -- Afferent Input -- Neurotransmitters and Neuromodulators Released From the Central Terminals of Primary Afferent Fibers -- Excitatory Amino Acids -- Purines -- Neurotrophins -- Second Messengers -- Dorsal Horn Neurons -- Interneurons -- Dorsal Horn Nonneuronal Cells -- Spinal Control of Pain -- Central Sensitization -- Phenotype Changes During Chronic Pain -- The Brain and Brainstem. , Cerebral Mechanisms of Pain -- Chronic Pain -- Endogenous Control of Pain -- Brainstem -- Brain -- Future Directions in Pain Control -- References -- Chapter 10 Taste and Olfaction -- Introduction -- Taste -- Taste Stimuli -- A Word About Psychophysics -- Transduction of Taste Stimuli -- Anatomy of the Taste System -- Physiology of Taste -- Theories of Taste Coding -- Conclusions -- Olfaction -- Overview -- Processing of Odorant Stimuli -- Conclusion -- Future Directions -- References -- Chapter 11 Food and Fluid Intake -- Introduction -- Food Intake and Energy Balance -- Metabolic Signals and Their Mediation -- Hypothalamic Systems Involved in Food Intake -- The Role of Reward in Food Intake Control -- Satiety Signaling -- Peripheral Peptide Satiety Signaling -- Interactions Among Control Systems -- Summary -- Water Intake and Fluid Balance -- Osmotic and Hypovolemic Signals That Stimulate Water Intake -- Cellular Dehydration and Brain Osmosensors -- Circumventricular Organs and Hypovolemic Water Intake -- Satiety Signals for Water Intake -- Interactions Among Other Control Systems -- Summary -- References -- Chapter 12 Sexual Behavior -- Why Sex? -- Sex Differentiation -- Fish and Reptiles -- Birds -- Mammals -- Patterns of Sexual Behavior in Mammals -- Female Reproductive Cycles -- Copulatory Patterns Common Across Mammalian Species -- Testing Paradigms -- Tests of Sexual Motivation -- Tests of Female Attractivity, Proceptivity, and Receptivity -- Tests of Male Copulatory Behavior -- Tests of Penile Function -- The Urethrogenital Reflex -- Principles of Hormonal Action -- Genomic Effects -- Rapid, Nongenomic Effects -- Activation of Female Sexual Behavior by Gonadal Hormones -- Dependence of Most Nonprimate Species on Steroid Hormones -- Increased Likelihood of Copulation by Periovulatory Female Primates -- Hormonal Control of Sensory Processes. , Systemically Administered Drugs Affect Female Sexual Behavior.
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  • 3
    Online Resource
    Online Resource
    Oxford :Oxford University Press, Incorporated,
    Keywords: Aggressiveness-Physiological aspects-Handbooks, manuals, etc. ; Electronic books.
    Description / Table of Contents: The primary goal of this book is to summarize and synthesize recent advances in the biological study of aggression. As most aggressive encounters among human and non-human animals represent a male proclivity, the research in this book describes and discusses studies using the most appropriate murine model: testosterone-dependent offensive inter-male aggression, which is typically measured in resident-intruder or isolation-induced aggression tests. The research also emphasizes various molecules that have been linked to aggression tests. The research also emphasizes various molecules that have been linked to aggression by the latest gene-targeting and pharmacological techniques. Although the evidence continues to point to androgens and serotonin (5-HT) as major hormonal and neurotransmitter factors in aggressive behavior, recent work with GABA, dopamine, vasopressin, and other factors, such as nitric oxide, has revealed significant interactions with the neural circuitry underlying aggression.
    Type of Medium: Online Resource
    Pages: 1 online resource (529 pages)
    Edition: 1st ed.
    ISBN: 9780198037767
    DDC: 155.232
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cary :Oxford University Press, Incorporated,
    Keywords: Photoperiodism. ; Electronic books.
    Description / Table of Contents: This book examines the role of photoperiod in timing seasonal adaptations in plants, invertebrates, and vertebrates. The current literature is distinctly separated among researchers working with these different taxa. The field is poised to make rapid progress in the understanding of seasonal clocks at all levels of analysis and this book will stimulate cross-talk among investigators from all related disciplines.
    Type of Medium: Online Resource
    Pages: 1 online resource (596 pages)
    Edition: 1st ed.
    ISBN: 9780199714636
    DDC: 612/.022
    Language: English
    Note: Intro -- Contents -- Contributors -- Part I. Photoperiodism in Plants and Fungi -- Overview -- 1. Photoperiodic Flowering in the Long-Day Plant Arabidopsis thaliana -- 2. Photoperiodic Control of Flowering in the Short-Day Plant Oryza sativa -- 3. The Photoperiodic Flowering Response in Pharbitis nil -- 4. Photoperiodic Control of Flowering in Lemna -- 5. Photoperiodic Control of Dormancy and Flowering in Trees -- 6. Integration of Photoperiodic Timing and Vernalization in Arabidopsis -- 7. Seasonality and Photoperiodism in Fungi -- Part II. Photoperiodism in Invertebrates -- Overview -- 8. Photoperiodism in Mollusks -- 9. Photoperiodism in Copepods -- 10. Photoperiodism in Insects: Migration and Diapause Responses -- 11. Photoperiodism in Insects: Perception of Light and the Role of Clock Genes -- 12. Photoperiodism in Insects: Molecular Basis and Consequences of Diapause -- 13. Photoperiodism in Insects: Effects on Morphology -- 14. Photoperiodism in Insects: Aphid Polyphenism -- Part III. Photoperiodism in Vertebrates -- Overview -- 15. Photoperiodism in Fishes -- 16. Photoperiodism in Amphibians and Reptiles -- 17. Photoperiodism and Reproduction in Birds -- 18. Genetic and Molecular Mechanisms of Avian Photoperiodism -- 19. Photoperiodism in Mammals: Regulation of Nonreproductive Traits -- 20. Photoperiodism and Reproduction in Mammals -- 21. Genetic and Molecular Mechanisms of Mammalian Photoperiodism -- Epilogue: Future Directions -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 19 (1995), S. 0 
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: In addition to the well-documented seasonal cycles of mating and birth, there are also significant seasonal cycles of illness and death among many animal populations. Challenging winter conditions (i.e., low ambient temperature and decreased food availability) can directly induce death via hypothermia, starvation, or shock. Coping with these challenges can also indirectly increase morbidity and mortality by increasing glucocorticoid secretion, which can compromise immune function. Many environmental challenges are recurrent and thus predictable; animals could enhance survival, and presumably increase fitness, if they could anticipate immunologically challenging conditions in order to cope with these seasonal threats to health. The annual cycle of changing photoperiod provides an accurate indicator of time of year and thus allows immunological adjustments prior to the deterioration of conditions. Pineal melatonin codes day length information. Short day lengths enhance several aspects of immune function in laboratory studies, and melatonin appears to mediate many of the enhanced immunological effects of photoperiod. Generally, field studies report compromised immune function during the short days of autumn and winter. The conflict between laboratory and field data is addressed with a multifactor approach. The evidence for seasonal fluctuations in lymphatic tissue size and structure, as well as immune function and disease processes, is reviewed. The role of pineal melatonin and the hormones regulated by melatonin is discussed from an evolutionary and adaptive functional perspective. Finally, the clinical significance of seasonal fluctuations in immune function is presented. Taken together, it appears that seasonal fluctuations in immune parameters, mediated by melatonin, could have profound effects on the etiology and progression of diseases in humans and nonhuman animals. An adaptive functional perspective is critical to gain insights into the interaction among melatonin, immune function, and disease processes.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Journal of pineal research 33 (2002), S. 0 
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Many non-tropical rodent species rely on photoperiod as the primary cue to co-ordinate seasonally appropriate changes in physiology and behavior. Among these seasonal changes, several rodent species (e.g. deer mice, prairie voles, Siberian hamsters) adjust immune function in response to changes in ambient day lengths. The goals of the present study were to examine the effects of photoperiod on immune function of Syrian hamsters (Mesocricetus auratus), and to determine the role of melatonin in mediating photoperiodic changes in immunity. In Experiment 1, male Syrian hamsters were housed in long (LD 14:10) or short days (LD 10:14) for 10 wk. In Experiment 2, hamsters were housed in long days and half of the animals were given 10 consecutive days of i.p. melatonin injections (15 μg) in the early evening, while the remaining animals received injections of the vehicle alone. After the respective experimental manipulations, animals were injected with the antigen, keyhole limpet hemocyanin (KLH), blood samples were obtained and anti-KLH IgG antibody production was assessed. In Experiment 1, short-day hamsters underwent gonadal regression and reduced serum testosterone as well as displayed increased humoral immune function compared with long-day animals. In Experiment 2, short-term melatonin treatment did not affect gonadal mass, testosterone or humoral immune function. These results confirm previous findings of photoperiodic changes in immunity in rodents and suggest that changes in humoral immunity are not due to short-term changes in melatonin.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of pineal research 25 (1998), S. 0 
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Cessation of breeding is central among the suite of winter-coping strategies used by small rodents to survive energy-demanding winter conditions. Animals use photoperiod to predict the onset of winter and initiate, well in advance of deteriorating conditions, seasonal adaptations. Exposure to short photoperiod leads to regression of the reproductive system in long-day breeding animals. Likewise, exposure to short days leads to enhanced immune function among several rodent species studied. Because dehydroepiandrosterone (DHEA) increases immune function in virtually all studies reported to date, we sought to determine if DHEA concentrations might be influenced by photoperiod, thereby suggesting a mechanism whereby short photoperiod may enhance immune function. Male deer mice (Peromyscus maniculatus) were exposed to either short or long days for 10 weeks. Short photoperiods caused significant reduction in all reproductive organs measured relative to animals housed in long days. However, DHEA concentrations did not differ between short- and long-day mice. Taken together, these data suggest that short-day enhancement of immune function in deer mice is independent of DHEA concentrations.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neuroendocrinology 9 (1997), S. 0 
    ISSN: 1365-2826
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Oxytocin (OT) has been reported to mediate aggressive and affiliative behaviours in several species. The behavioural role of OT has been established with physiological manipulations that potentially affected blood pressure, which may have indirectly affected the behaviours under study. To provide converging evidence of the physiological role of OT in aggressive behavior, wild type (WT), heterozygous (OT−/+), and homozygous (OT−/−) mutant mice were tested in two aggression paradigms. In general, there was no significant difference in aggressiveness between WT and OT−/+ mice. However, there were significant reductions in the duration of aggressive behaviors among OT−/− animals, especially in agonistic encounters within neutral arenas. The OT−/− mice did not exhibit any sensorimotor deficits or display any altered general anxiety levels that may have accounted for the observed reduction in aggressive behavior. These data indicate that aggression is mediated in part by OT in mice and that increased aggressiveness is not an obligatory phenotypic result of targeted genetic disruption of any gene.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard
    Journal of pineal research 30 (2001), S. 0 
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The present study was designed (1) to determine the extent to which male prairie voles (Microtus ochrogaster) alter immune status in response to short-day lengths, (2) to evaluate the role of melatonin in coordinating these alterations in immune function, and (3) to assess the association between alterations in immune function and reproductive responsiveness to photoperiod. Male voles were housed in either long- or short-day lengths for 10 wk; voles in short days were subdivided into reproductive “responders” (R) or “non-responders” (NR) based on testicular mass at autopsy. After 10 wk of exposure to photoperiodic conditions, cell-mediated immune function was evaluated using an in vitro splenocyte proliferation assay. The direct effects of melatonin on immune cells were evaluated by adding melatonin to one-half of the cultures in each experimental condition. Melatonin treatment led to enhanced splenocyte proliferation for all experimental groups. Neither photoperiodic condition nor reproductive status was associated with alterations in immune function or the degree of immuno-enhancing effects of melatonin. Taken together, the results of the present study suggest that melatonin is capable of enhancing immune function in male voles potentially by acting directly on immune cells.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Copenhagen : Munksgaard
    Journal of pineal research 28 (2000), S. 0 
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The seasonal effects of photoperiod on reproduction are mediated by melatonin, and it is hypothesized that increased immune function in short days is due to the increase in the duration of nightly melatonin secretion. Melatonin can act both directly and indirectly on target tissue within the immune system. The present study sought to tease apart the direct and indirect effects of melatonin on one aspect of immune function by examining the influence of in vitro melatonin on splenocyte proliferation in female prairie voles held in long (LD 16:8) or short (LD 8:16) days. Splenocyte proliferation in response to the T-cell mitogen concanavalin A was enhanced by the addition of melatonin in vitro, as compared to cultures receiving no melatonin. Body mass increased in short-day housed prairie voles, indicating that the animals were responsive to photoperiod. However, photoperiod did not affect splenocyte proliferation in the present study. These results support the hypothesis that melatonin exerts a direct effect on splenocyte proliferation, potentially via high-affinity melatonin receptors localized on splenocytes. The findings also indicate that, irrespective of photoperiod, melatonin exerts direct effects on splenocytes to enhance immune function.
    Type of Medium: Electronic Resource
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