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  • 1
    Online Resource
    Online Resource
    Applying Big Data to Address the Social Determinants of Health in Oncology : Proceedings of a Workshop. (2020)
    Washington, D.C. :National Academies Press,
    Details
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (83 pages)
    Edition: 1st ed.
    ISBN: 9780309679046
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6320697
    Language: English
    Note: Intro -- FrontMatter -- Reviewers -- Acknowledgments -- Contents -- Boxes and Figures -- Acronyms and Abbreviations -- Proceedings of a Workshop -- Appendix A: Statement of Task -- Appendix B: Workshop Agenda.
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  • 2
    Electronic Resource
    Electronic Resource
    Regulation of Cell-Cycle Progression and Cell Death in Breast Cancer (1997)
    Oxford, UK : Blackwell Publishing Ltd
    The @breast journal 3 (1997), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Tumorigenesis is often characterized by a combination of aberrant proliferation and the inappropriate suppression of apoptosis. In breast cancer, a variety of growth factors and hormones, as well as attachment to extracellular matrix, can regulate both cell growth and cell death via apoptosis, suggesting that the two processes may be closely linked. A better understanding of the mechanism by which those factors regulate the cell cycle and the apoptotic pathways could therefore be very useful in designing novel therapies for breast cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1524-4741.1997.tb00202.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Breast cancer biology blossoms in the clinic (1998)
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 761-762 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] BREAST CANCER is a leading and feared cause of cancer deaths among women. The antiestrogen, tamoxifen, has been used in its treatment for more than 20 years and now recent clinical trials point to a promising role for tamoxifen and related agents in breast cancer prevention1–3. In addition, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0798-761
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Defining a role for c-Myc in breast tumorigenesis (1997)
    Springer
    Breast cancer research and treatment 44 (1997), S. 1-22 
    Details
    ISSN: 1573-7217
    Keywords: apoptosis ; cell cycle ; amplification ; overexpression ; breast neoplasia ; c-Myc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The proto-oncogene c-myc is commonly amplified and overexpressed in human breast tumors, and the tumorigenic potential of c-myc overexpression in mammary tissue has been confirmed by both in vitro and in vivo models of breast cancer. However, the mechanisms by which Myc promotes tumorigenesis are not well understood. Recent evidence indicates that Myc can promote cell proliferation as well as cell death via apoptosis. These studies provide new insight and impetus in defining a role for c-Myc in breast tumorigenesis and may point toward novel targets for breast cancer therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005858611585
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The Loss of Estrogen and Progesterone Receptor Gene Expression in Human Breast Cancer (1998)
    Springer
    Journal of mammary gland biology and neoplasia 3 (1998), S. 85-94 
    Details
    ISSN: 1573-7039
    Keywords: ESTROGEN RECEPTOR ; PROGESTERONE RECEPTOR ; HOMOZYGOUS DELETION ; MUTATION ; CpG ISLAND METHYLATION
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hormone responsiveness is a critical determinantof breast cancer progression and management, and theresponse to endocrine therapy is highly correlated withthe estrogen receptor (ER)3 and progesterone receptor (PR) status of tumor cells. Thus, keyareas of study in breast cancer are those mechanismsthat regulate ER and PR expression in normal andmalignant breast tissues. One-third of all breastcancers lack ER and PR; these conditions are associatedwith less differentiated tumors and poorer clinicaloutcome. In addition, approximately one-half ofER-positive tumors lack PR protein and patients withthis phenotype are less likely to respond tohormonal therapies than those whose tumors express bothreceptors. Since PR is induced by ER; its presence is amarker of a functional ER. In this review, we will discuss possible mechanisms for loss of ER andPR gene expression, especially structural changes withineach gene including deletions, polymorphisms ormethylation. Improved understanding of the pathways that lead to loss of ER and/or PR proteinsshould allow the development of better predictiveindicators as well as novel therapeutic approaches totarget these hormone-independent cancers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018778403001
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  • 6
    Electronic Resource
    Electronic Resource
    The genetic map around the tail kinks (tk) locus on mouse Chromosome 9 (1993)
    Springer
    Mammalian genome 4 (1993), S. 560-564 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Tail kinks (tk) is a classical mouse skeletal mutation, located on Chromosome (Chr) 9. As the first step for the positional cloning of the tk gene, we have established a genetic map of a region surrounding the tk locus by generating a backcross segregating for tk. From this backcross, 1004 progeny were analyzed for the coat-color phenotype of the proximally located dilute (d) gene and for the distally flanking microsatellite marker, D9Mit12. Fifty-six recombinants between d and tk and 75 recombinants between tk and D9Mit12 were identified, completing a panel of 130 recombinants including one double recombinant. This panel allowed us to map five microsatellite loci as well as d and Mod-1 with respect to tk. We show that one of the microsatellite markers mapped, D9Mit9, does not recombine at all with tk in our backcross. This indicates that the D9Mit9 locus will serve as a good starting point for a chromosomal walk to the tk gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00361385
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  • 7
    Electronic Resource
    Electronic Resource
    Mapping of the Mod-1 locus on mouse Chromosome 9 (1993)
    Springer
    Mammalian genome 4 (1993), S. 333-337 
    Details
    ISSN: 1432-1777
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A new method for typing the Mod-1 locus on mouse Chromosome (Chr) 9 was developed, based on restriction fragment length polymorphism (RFLP) within a polymerase chain reaction (PCR)-amplified fragment. The new method led us to revise the strain distribution pattern (SDP) of Mod-1 in the BXD (C57BL/6JxDBA/2J) and AKXD (AKR/J x DBA/2J) recombinant inbred (RI) strains. The new SDP eliminates several previously reported examples of double recombination events between Mod-1 and the closest flanking loci in the BXD and AKXD strains. In the BXD strains, the revised SDP of Mod-1 was identical to that of the Mod-1-related D9Rtil locus. Thus, the identity of D9Rtil as a Mod-1-related locus rather than Mod-1 itself is in question. The method was also applied to an interspecific backcross panel between an inbred strain of Mus musculus molossinus (MSM/Ms) and C57BL/6J to map Mod-1 with respect to surrounding microsatellite loci, defining the proximal localization of Mod-1 with respect to D9Mit10 with a genetic distance of 0.6±0.6 cM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00357093
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Male accessory sex glands produce heparin-binding proteins that bind to cauda epididymal spermatozoa and are testosterone dependent (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 25 (1990), S. 237-246 
    Details
    ISSN: 1040-452X
    Keywords: Seminal vesicle ; Prostate ; Bulbourethral gland ; Seminal plasma ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Heparin binds to bovine sperm and stimulates capacitation in vitro. Seminal plasma alters the ability of epididymal sperm to bind heparin, and several heparin-binding proteins (HBPs) have been identified in bull seminal plasma. This study had three objectives: (1) to identify production sites of seminal plasma HBPs, (2) to determine which HBPs bound to cauda epididymal sperm, and (3) to determine whether presence of HBPs was testosterone dependent. Proteins from bull or rat seminal vesicles, prostates, and bulbourethral glands were separated by heparin affinity high-performance liquid chromatography. HBPs were found in all accessory glands of rats and bulls, but the major source of bovine seminal plasma HBPs appeared to be seminal vesicles. Between 25% and 50% of the protein from each gland bound to the heparin column, and NaCl concentrations required to elute proteins ranged from 0.15 to 1.4 M. One-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) showed that major HBPs were relatively small, with molecular weights between 13 and 31 kDa, but some HBPs also exhibited higher molecular weights, between 40 and 100 kDa. Radioiodinated HBPs from each bovine gland were incubated with epididymal sperm. Labeled HBPs binding to sperm exhibited molecular weights of 14, 16, 24, and 30 kDa as determined by SDS-PAGE and autoradiography. The HBP content of the accessory sex glands decreased significantly in castrated rats and was restored to levels of sham-operated controls by testosterone replacement. Heparin-binding proteins may play a role in fertilization by attaching to sperm surfaces, enabling heparin-like glycosaminoglycans in the female reproductive tract to induce capacitation.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080250305
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