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  • 1
    Online Resource
    Online Resource
    Basel :S. Karger AG,
    Keywords: Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (155 pages)
    Edition: 1st ed.
    ISBN: 9783805596657
    DDC: 572/.54
    Language: English
    Note: Cover -- Contents -- Preface -- General -- Roles of Stress-Inducible Carbon Monoxidein the Regulation of Liver Function -- Abstract -- CO Derived from HO-1 in Macrophages -- CO Derived from HO-2 Targets Hepatic Stellate Cells to Relax Sinusoids -- CBS as a CO Sensor Mined by Metabolomic Analyses -- Acknowledgments -- References -- Intraluminal Gas and GastrointestinalDiseases -- Abstract -- Esophagus -- Stomach and Duodenum -- Small and Large Intestine -- Clinical Problems -- Conclusions -- References -- Therapeutic Medical Gas -- Gas and Medical Application: I. CO -- Analysis of Breath CO and Application toHemodynamic Monitoring -- Abstract -- Procedures for Hemodynamic Monitoring by EGA -- Agreement of Cardiac Output Estimations between EGA and PAC -- Agreement of Circulating Blood Volumetry between EGA and the ConventionalMethod -- Accuracy of Hemodynamic Monitoring by the EGA Method -- Advantages of the EGA Method -- Disadvantages of the EGA Method -- Conclusions -- References -- CO and Its Application to GastrointestinalDisease -- Abstract -- Physiological Role of CO in the Gastrointestinal Tract -- Mechanism of CO Action -- Distribution and Regulation of Heme Oxygenase in the Gastrointestinal Tract -- Anti- Apoptotic and Anti- Inflammatory Effect of CO -- Inflammatory Bowel Disease and CO -- Conclusions -- References -- Gas and Medical Application: II. NO -- Clinical Application of Inhaled Nitric Oxide -- Abstract -- Impairment of NO- Dependent Responses in Pulmonary Hypertension -- Discovery of NO Inhalation Therapy in Animals and Humans -- Physiological Effect of NO Inhalation on Circulation -- Effects of Inhaled NO on the PAP -- Effects of inhaled NO on Arterial Oxygenation (fig. 3) -- Clinical Application of NO Inhalation -- Effects of NO on the Development of Pulmonary Vascular Changes -- Effect of Inhaled NO on Recovery of PH. , Effect of Inhaled NO on Remote Organ (fig. 4) -- References -- Inhaled Nitric Oxide and Clinical Application -- Gas and Medical Application: III. H2S -- Hydrogen Sulfide in the GastrointestinalTract: Friend or Foe? -- Abstract -- Benevolent Role of H2S Gas in the Gastrointestinal Tract -- Notoriety Role of H2S Gas in the Gastrointestinal Tract -- Conclusion: Great Pharmacological Potential of H2S in the Gastrointestinal Tract -- Acknowledgement -- References -- Role of Hydrogen Sulfide in Colitis -- Abstract -- H2S Synthesis in the Gastrointestinal Tract -- Role of H2S in colonic inflammation -- Future Perspectives -- References -- HCO3 - Stimulatory Action of Hydrogen Sulfidein Rat Duodenum -- Abstract -- Materials and Methods -- Results -- Discussion -- References -- Gas and Medical Application: IV. H2 -- Hydrogen and Medical Application -- Abstract -- Chemistry of Hydrogen -- Physiology of Hydrogen -- Protective Mechanism of Hydrogen -- Medical Use of Hydrogen -- Conclusions -- References -- Gas and Medical Application: V. 13C -- 13C- Breath Test for Studying Physiology andPathophysiology by Using ExperimentalAnimals -- Abstract -- Breath Test in Experimental Animals -- Test Meals for the Breath Test in Animals -- Collection of Expired Breath Samples -- Measuring Expired Breath Samples -- Pharmacokinetic Data Analysis -- Breath Test for Evaluating H. pylori Infection -- Breath Test for Evaluating Gastric Emptying -- Breath Test for Evaluating Liver Function -- Breath Test for Evaluating Pancreatic Exocrine Function -- Breath Test for Evaluating Sugar and Lipid Metabolism -- Breath Test for Evaluating Gastrocecal Transit Time -- Breath Test for Evaluating Cachexia -- Simple and Noninvasive Breath Test in Rats -- Application of the Simple and Noninvasive Breath Test for Mice -- Conclusion -- References -- Carbon- 13 and Its Clinical Application. , Abstract -- 13C in Medical Practice - To the Present -- To the Future -- Conclusion -- Acknowledgements -- References -- Gas and Medical Application: VI. Others -- Acetone Response during Graded andProlonged Exercise -- Abstract -- Materials and Methods -- Results -- Discussion -- Conclusions -- References -- Findings of Skin Gases and Their Possibilitiesin Healthcare Monitoring -- Abstract -- Analytical Procedure -- Skin Gases -- Acknowledgement -- References -- Phytoncide - Its Properties and Applicationsin Practical Use -- Abstract -- Preparation of Phytoncide Solution -- Antioxidant Activity -- Bacterial Eradication and Deodorization -- Effect on Restriction Stress -- Influence on Water Immersion Restriction Stress -- Conclusion -- References -- Author Index -- Subject Index.
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  • 2
    Publication Date: 2019-07-17
    Description: While modern sampling techniques, such as autonomous underwater vehicles, are increasing our knowledge of the fauna beneath Antarctic sea ice of only a few meters in depth, greater sampling difficulties mean that little is known about the marine life underneath Antarctic ice shelves over 100 m thick. In this study, we present underwater images showing the underside of an Antarctic ice shelf covered by aggregated invertebrate communities, most likely cnidarians and isopods. These images, taken at an average depth of 145 m, were obtained with a digital still camera system attached to Weddell seals Leptonychotes weddellii foraging just beneath the ice shelf. Our observations indicate that, similar to the sea floor, ice shelves serve as an important habitat for a remarkable amount of marine invertebrate fauna in Antarctica.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 3
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    In:  EPIC320th Biennial Conference on the Biology of Marine Mammals, Dunedin, New Zeeland, 2013-12-09-2013-12-13
    Publication Date: 2014-05-13
    Description: Bio-logging systems are a useful tool for understanding the behavior of marine mammals and their environmental conditions.In particular, accelerometer data provide characteristic information on feeding events, posture and body movement of the animals. Naito et al. (2010) reported on acceleration patterns of feeding behavior and unknown acceleration patterns of jaw motion of two free-ranging adult female Weddell seals (No. 06 and No.16) instrumented in Atka Bay (70º39’S, 08º15’W) in early December 2008. Although acceleration pattern of feeding behaviour was inferred by data obtained from the feeding experiments of captive seals, acceleration pattern of non-feeding behaviour has never been examined in detail. Here we re-examined those data【depth (±0.1m), environmental temperature (±0.1℃), and two way acceleration, heave(x) and surge (y) data at 32Hz were measured over three days】to obtain new insight into the behaviour of the species. We detected low frequency cycle with attenuating pattern from two adult female Weddell seals. Individual (No.06) and (No.16) showed average cycle of 0.217±0.007 sec. and 0.161±0.008 sec., average duration of 4.43±0.225 sec. and 4.08±0.68 sec., and average depth of 2.06±0.42 m and 6.21±1.19 m, respectively. We isolated 135 events in 269 dives of the seal (No.06) and 29 events in 167 dives of the seal (No.16). It is well known that Weddell seals produce a number of vocalizations at shallow depths during breeding season and these vocalizations assumed to be related to mating behaviour. However, frequency of our data was lower than that of usual vocalization. Although the function of this low frequency pattern is still unknown, we hypothesize that low frequency pattern emitted by shivering some parts of lower jaw (or laryngeal organ) have an unknown function like “social call-interaction” during the breeding season.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
    Format: application/pdf
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  • 4
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    In:  EPIC3African Marine Mammal Colloquium, Kleinbaai, South Africa, 2012-05-21-2012-05-25
    Publication Date: 2019-07-17
    Description: A proposed study into the ranging and diving behaviour of Ross seals Ommatophoca rossii in an area of high relative abundance in the eastern Weddell Sea, and their diet through direct (stomach contents and scats) and indirect (dive behaviour, jaw activity recordings and stable isotope analyses) means was turned down for the SANAP research period 2012-2014. The aim was to improve knowledge of the way oceanographic conditions affect one of the four true Antarctic species of seal breeding off the Princess Martha Coast, Antarctica in the King Haakon VII Sea with a view to using Ross seals as bioindicators of environmental change under a scenario of ocean warming, progressive disintegration of the West Antarctic ice-sheet and decrease in sea-ice coverage. Designed to build on earlier SANAP seal research in this area of pack-ice in the late 1970’s and early 1990’s, using the new SA Agulhas II as the research platform, it would apply latest technology such as Conductivity, Temperature, Depth (CTD)-Satellite Relay Data Loggers (SRDLs), Mandible Accelerometers (MACs) and stable isotope analyses to characterise Ross seal distribution, diet and physical characteristics of the water column where they forage. Ross seals are ideal candidates as they made long foraging trips north of the pack-ice into pelagic areas of the Southern Ocean for most of the year (in 2001) and returned to the pack-ice only for short periods to breed and moult. The comprehensive analysis and synthesis of biological and physical data perceivably could make an important contribution to determining relationships between hydrographic features, ocean currents, sea floor characteristics, prey dynamics, and the distribution and abundance of marine top predators. A possible way forward in the use of a top predator as an oceanographic profiler to detailing the structure and function of the pack-ice ecosystem likely affected by global warming is presented.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 5
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
    Format: application/pdf
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  • 6
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    In:  EPIC3Xth SCAR International Biology Symposium, July 26-31, 2009, Hokkaido University, Sapporo, Hokkaido, Japan.
    Publication Date: 2019-07-17
    Description: Seals are supposed to forage in efficient manner during dives due to strict physiological constraints. Understanding of foraging behavior is essential for a comprehensive understanding of overall diving behavior. Although several techniques of measuring feeding behavior have been developed, direct measurement of feeding efficiency has not been made. Simultaneous measurement of feeding rate and effort is essential to study feeding efficiency. In order to develop simultaneous measurement of feeding events and effort (swim stroke) we tested a new mandible accelerometer method on free ranging Weddell seals in the Atka Bay, Eckstroem Ice Shelf, Antarctica in November/December 2008. Before to conduct the field test on Weddell seals, we attached the accelerometers (D2GT; 15mm in diameter, 53mm in length, 18g in air, Little Leonardo, Tokyo) on the mandible of captive harp seals. The experiment showed that frequency filtered signal (Igor Filtering Design Laboratory: IFDL WaveMetrics, Lake Oswego, OR U.S.A.) of acceleration from the mandible is quite distinct at moments of prey ingestion allowing us to use mandible accelerometer for the detection of feeding events of seals in the wild. We attached the same accelerometers equipped with two sensors (surge and heave axes) on the mandible of Weddell seals to detect movements associated with feeding and also swim activities. We successfully obtained feeding data together with stroke and depth data. Here we report the results of the diving behavior and foraging success of Weddell seals in Antarctica.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
    Format: application/pdf
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  • 7
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Marine mammal science 19 (2003), S. 0 
    ISSN: 1748-7692
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Recent studies have shown that Helicobacter pylori affects intracellular signal transduction in host cells, leading to the activation of transcriptional factors and the induction of pro-inflammatory cytokines. On the other hand, rebamipide, an anti-gastritis and anti-ulcer agent, could scavenge reactive oxygen species and reduce interleukin-8 (IL-8) expression in gastric epithelial cells induced by H. pylori-stimulation through the attenuated activation of nuclear factor-κB (NF-κB).Aims : In this study, we investigated the effects of rebamipide on gene expression in H. pylori-stimulated epithelial cells using DNA chip.Methods : H. pylori water extract (HPE) was prepared from NCTC11637, the type strain of H. pylori. Total RNA was extracted from MKN45 cells, a human gastric cancer cell line, following HPE-stimulation with and without rebamipide for 3 h, and differences in gene expression profiles were observed using GeneChip and Human 6800 probe array.Results : The GeneChip analysis demonstrated that 132 up-regulated genes and 873 down-regulated genes, such as growth factors, chemokines and transcription factors, were detected in MKN45 cells 3 h after stimulation of H. pylori. Among them, several genes, including bFGF, RANTES and MIP-2β, were previously unknown to be expressed in H. pylori-stimulated human gastric cells. Rebamipide reduced expression of 119 genes encoding cytokines, growth factors and their receptors and transcription factors.Conclusions : These findings suggest that rebamipide could inhibit inflammatory reactions and tumour progression by modifying H. pylori infection-induced gene expression in gastric epithelial cells.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Neutrophils activation and tumour necrosis factor-α (TNF-α) induction play a critical role in aspirin-induced gastric mucosal injury. Peroxisome proliferator-activated receptor-γ (PPAR-γ), a member of the nuclear hormone receptor superfamily, has recently been implicated as a regulator of inflammatory responses. The aim of the present study was to determine whether pioglitazone, a specific PPAR-γ ligand, can ameliorate aspirin-induced gastric mucosal injury in rats, and whether the agent can inhibit the increase in neutrophil accumulation associated with TNF-α expression.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Aspirin-induced injury was produced by the intragastric administration of aspirin (200 mg/kg) and HCl (0.15 N, 8.0 mL/kg). Pioglitazone was given to the rats by gastric intubation 1 h before the aspirin administration. Thiobarbituric acid-reactive substances and tissue-associated myeloperoxidase activity were measured in gastric mucosa as indices of lipid peroxidation and neutrophil infiltration. The gastric concentration of TNF-α and the expression of TNF-α mRNA was determined by ELISA and reverse transcriptase-polymerase chain reaction.〈section xml:id="abs1-3"〉〈title type="main"〉Results:The intragastric administration of acidified aspirin induced hyperemia and haemorrhagic erosions in rat stomachs. The increase in the total gastric erosive area after aspirin administration was significantly inhibited by treatment with pioglitazone in a dose-dependent manner. The increases in thiobarbituric acid-reactive substances and myeloperoxidase activity after aspirin administration were both significantly inhibited by pre-treatment with pioglitazone (10 mg/kg). The gastric content of TNF-α increased and the expression of TNF-α mRNA was up-regulated after aspirin treatment. However, the peak TNF-α mRNA expression 1 h after aspirin administration was inhibited by pioglitazone.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:Based on these data, the beneficial effects of pioglitazone on aspirin-induced gastric mucosal injury may be attributed to its anti-inflammatory properties.
    Type of Medium: Electronic Resource
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