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  • 1
    Electronic Resource
    Electronic Resource
    Electrochemical oxidation of enamines in the presence of organic anions (1979)
    s.l. : American Chemical Society
    The @journal of organic chemistry 44 (1979), S. 3519-3523 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo01334a016
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  • 2
    Electronic Resource
    Electronic Resource
    Electrochemical oxidation of benzophenone hydrazones (1983)
    s.l. : American Chemical Society
    The @journal of organic chemistry 48 (1983), S. 2968-2972 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00166a006
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of P doping on the thermoelectric properties of β-FeSi2 (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 2138-2142 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The effects of P substitution for Si as an n-type dopant on the thermoelectric properties of hot-pressed β-FeSi2 were investigated. The Seebeck coefficient, electrical resistivity, and thermal conductivity of the FeSi2−xPx were measured from room temperature to 1100 K, and then the power factor and figure of merit were evaluated. The Seebeck coefficient of the hot-pressed FeSi2−xPx was negative, indicating that P atoms were definitely substituted for Si atoms as an n-type dopant in the β phase. The samples with x=0.02 and 0.04 had a Seebeck coefficient greater than that of the conventional hot-pressed Fe0.98Co0.02Si2 below 800 K. The electrical resistivity was significantly reduced by P doping, especially in the lower temperature range, and slightly decreased with increasing P content. The log ρ−1/T plots of the P-doped samples exhibited a specific behavior below 480 K, which was not observed in the case of the nondoped sample. The thermal conductivity of the P-doped sample was smaller than that of the nondoped sample in spite of the larger amount of the metallic cursive-epsilon phase. The figure of merit was significantly enhanced by P doping as compared with that of the nondoped β-FeSi2, and a high thermoelectric performance, almost the same as that of the conventional Fe0.98Co0.02Si2, was obtained by P doping into β-FeSi2. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1436302
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  • 4
    Electronic Resource
    Electronic Resource
    Gambieric acids, new potent antifungal substances with unprecedented polyether structures from a marine dinoflagellate Gambierdiscus toxicus (1992)
    s.l. : American Chemical Society
    The @journal of organic chemistry 57 (1992), S. 5448-5453 
    Details
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jo00046a029
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  • 5
    Electronic Resource
    Electronic Resource
    In vivo elimination of CD25+ regulatory T cells leads to tumor rejection of B16F10 melanoma, when combined with interleukin-12 gene transfer (2004)
    Oxford, UK; Malden, USA : Munksgaard International Publishers
    Experimental dermatology 13 (2004), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  CD4+CD25+ T cells are an important population that plays a crucial role in the maintenance of peripheral self-tolerance. Recently, it was shown that the elimination of these cells by in vivo administration of anti-CD25 monoclonal antibody (mAb) caused the regression of highly immunogenic tumors in syngeneic mice. In this study, we examined whether B16F10 melanoma cells regressed with the elimination of CD25+ regulatory T cells. We found the melanoma cells were not affected at all by in vivo anti-CD25 mAb administration alone but tumor rejection resulted in all mice when the administration was combined with IL-12 gene transfer to tumor cells. In vivo, depletion of natural killer (NK) cells or CD8+ T cells cancelled the tumor rejection. NK-cell depletion allowed IL-12-transfected B16F10 melanoma (B16/IL-12) to grow from an early stage and resulted in a more rapid tumor growth of B16/IL-12 than that in mice without administration of anti-CD25 mAb. On the other hand, CD8+ T-cell depletion did not affect the tumor growth in the early phase but allowed B16/IL-12 to grow in rather a late phase and resulted in almost the same degree of tumor growth as in mice without administration of anti-CD25 mAb. In a previous study, we showed that the elimination of CD4+ T cells enhanced the antitumor effect of B16/IL-12 and induced vitiligo-like coat color alteration. Therefore, we also examined the frequency of the change to a vitiligo-like coat color in mice showing tumor rejection caused by CD25+ T-cell elimination to compare with the mechanism enhancing the antitumor effects by cell elimination. The elimination of CD25+ T cells did not induce vitiligo-like coat color changes, though that of CD4+ T cells induced the change in 60% of mice. Furthermore, we confirmed that elimination of CD25+ T cells did not affect the T-helper (Th) 1/Th2 cytokine profile, while that of CD4+T cells abrogated the Th2 cytokines (IL-4 and IL-10) and resulted in a Th1-dominant cytokine profile in the tumor-draining lymph nodes (TDLNs) of B16/IL-12-bearing mice. These results indicate that in vivo depletion of CD25+ regulatory T cells is a potent useful adjuvant in immunotherapy of B16F10 melanoma, when combined with IL-12 gene transfer and that the enhancement of the antitumor effect by CD25+ T-cell depletion is mediated through CD8+ T cells and may differ from the enhancing mechanism caused by CD4+ T-cell depletion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0906-6705.2004.00198.x
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  • 6
    Electronic Resource
    Electronic Resource
    Gambieric acids: unprecedented potent antifungal substances isolated from cultures of a marine dinoflagellate Gambierdiscus toxicus (1992)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 114 (1992), S. 1102-1103 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00029a057
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  • 7
    Electronic Resource
    Electronic Resource
    Tissue Distribution of an Immunogenic Melanoma Associated Antigen, D-1 (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Periodontology 2000 7 (1994), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A human melanoma-associated antigen immunogenic in patients was recently identified by screening an expression cDNA library constructed from cultured human melanoma cell line with sera from patients with melanoma. The nucleic acid sequence of the cloned D-1 cDNA has no significant homology with previously reported mammalian genes. The cDNA D-1 encodes a peptide of about 37 kDa, which showed fivefold higher reactivity with sera from patients with melanoma than with sera from normal donors. In order to detect D-1 gene expression in vivo, in-situ hybridization and immunostaining with cRNA probe and murine anti-D-1 sera were carried out on surgically removed tissues. Digoxigenin-labeled cRNA D-1 was exclusively hybridized with mRNA in the cytoplasm of melanoma cells but not with keratinocytes and fibroblasts adjacent to melanoma nests. Polyclonal anti-D-1 antibodies were obtained by immunization of Balb/c mice with recombinant D-1 peptide and clearly reacted with melanoma cells but not with keratinocytes and fibroblasts, similar to the results of in-situ hybridization. The above information will help to assess the suitability of recombinant D-1 peptide to implement active specific immunotherapy in patients with melanoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0749.1994.tb00075.x
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  • 8
    Electronic Resource
    Electronic Resource
    Recent trends in Japanese research on the philosophy of science (1971)
    Springer
    Journal for general philosophy of science 2 (1971), S. 101-114 
    Details
    ISSN: 1572-8587
    Source: Springer Online Journal Archives 1860-2000
    Topics: Philosophy , Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Summary In Japan, the demand for the philosophy of science has recently increased, and in the last decade many changes have been brought about, among which the most remarkable is the rise of analytic philosophy. But such a tendency is not the one and only; other philosophical trends are important as well. Materialistic approaches to the matter may not be neglected, either. In addition, mathematicians and natural scientists (especially physicists and biologists) are also devoting considerable efforts to contribute to the philosophy of science.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01800690
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  • 9
    Electronic Resource
    Electronic Resource
    Synergistic antitumor effects of interleukin-12 gene transfer and systemic administration of interleukin-18 in a mouse bladder cancer model (1999)
    Springer
    Cancer immunology immunotherapy 48 (1999), S. 297-302 
    Details
    ISSN: 1432-0851
    Keywords: Key words Bladder cancer ; Interleukin-12 ; Interleukin-18
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We introduced the interleukin-12 (IL-12) gene into the mouse bladder cancer cell line (MBT2) to establish sublines that secrete bioactive IL-12. IL-12-secreting MBT2 (MBT2/IL-12) sublines were completely rejected when subcutaneously implanted into immunocompetent syngeneic C3H mice. Although this antitumor effect did not change when IL-12-secreting cells were injected into immunodeficient mice whose CD8+ T or CD4+ T cells had been depleted by the corresponding antibody, it was abrogated when natural killer cells were depleted by anti-asialoGM1 antibody. In addition, when parental MBT2 cells mixed with MBT2/IL-12 cells were subcutaneously injected into mice, admixed MBT2/IL-12 inhibited the growth of the parental tumor. Furthermore, this antitumor effect was enhanced by systemic IL-18 administration. This synergism was abrogated when the mice were treated with interferon-γ-neutralizing antibody in vivo. In conclusion, local secretion of IL-12 led to effective antitumor activity that was enhanced by systemic administration of IL-18. Interferon-γ plays an important role in the synergism of IL-12 gene transduction and systemic administration of IL-18.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002620050578
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  • 10
    Electronic Resource
    Electronic Resource
    Antimicrobial activities of polyether compounds of dinoflagellate origins (1990)
    Springer
    Journal of applied phycology 2 (1990), S. 305-308 
    Details
    ISSN: 1573-5176
    Keywords: polyether ; antimicrobial activity ; dinoflagellate ; antifungals ; chemical modification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Twelve polyether compounds originating from dinoflagellates were tested for growth-inhibiting activities againstAspergillus niger, Penicillium funiculosum, Candida rugosa, Escherichia coli, Bacillus megaterium andStaphylococcus aureus by a paper disc method. These polyethers represent six groups of different skeletons and originate from three species;Prorocentrum lima, Dinophysis fortii andGambierdiscus toxicus. Potent antifungal activities were observed with okadaic acid and its two congeners, desulfated yessotoxin, and ciguatoxin but not with okadaic acid esters, prorocentrolide, pectenotoxin-1, yessotoxin, maitotoxin, and desulphated maitotoxin. The antifungal activities and mouse lethalities of the polyethers were markedly affected by slight modification of their structures. Antibacterial potency of the tested compounds was not significant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02180919
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