GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    The Resistance Vasculature : A Publication of the University of Vermont Center for Vascular Research. (1991)
    Totowa, NJ :Humana Press,
    Details
    Keywords: Human physiology. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (473 pages)
    Edition: 1st ed.
    ISBN: 9781461204039
    Series Statement: Vascular Biomedicine Series
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6488938
    Language: English
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    GEOMAR EBL
  • 2
    Electronic Resource
    Electronic Resource
    PERIPHERAL VASCULATURE IN ESSENTIAL HYPERTENSION (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 23 (1996), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 〈list xml:id="l1" style="custom"〉1Haemodynamic evidence shows that in essential hypertension minimum vascular resistance and vascular pressor response are increased and that the vascular reserve is decreased.2The haemodynamic changes are most easily explained in terms of a generalized narrowing of the vasculature and an increase in the ratio between the thickness of the tunica media and the lumen diameter (media: lumen ratio), with no change in the functional properties of the smooth muscle itself.3Histological and in vitro studies of resistance vessels confirm these predictions. Moreover, the evidence indicates that these changes are associated mainly with remodelling (rearrangement of the same amount of material) of the vessels, rather than growth.4Although the alteration in small artery structure is usually appropriate to the actual blood pressure, the structure appears not only to be a secondary adaptation, but is also dependent on other factors, including neurohumoral factors.5The available evidence shows that normalization of the resistance vessel structure (by increasing lumen diameter and decreasing the media: lumen ratio) should be achieved not by inhibition of growth but by (reverse) remodelling. Recent evidence from clinical investigations shows that this can be achieved in essential hypertensive patients treated with the angiotensin-converting enzyme inhibitor perindopril.6The role of the resistance vasculature as a primary determinant of blood pressure remains unclear. It is suggested that the requirement for normalization of resistance vascular structure is due to a need to increase the vascular reserve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1996.tb03034.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    THE EFFECT OF COCAINE AND DESIPRAMINE ON NEURONAL UPTAKE OF [3H]-NORADRENALINE AND SENSITIVITY TO NORADRENALINE OF RAT MESENTERIC RESISTANCE ARTERIES (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 21 (1994), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of cocaine and desipramine (DMI) on neuronal uptake (uptake1) of [3H]-noradrenaline (NA) and isometric tension development to exogenous NA were assessed in mesenteric resistance arteries of Wistar rats.2. Both drugs concentration-dependently inhibited [3H]-NA uptake1, DMI being more potent than cocaine. The maximum inhibition produced by each drug was the same as that produced by denervation with 6-hydroxydopamine. In denervated vessels there was no effect of cocaine on [3H]-NA uptakel.3. Cocaine, in the same concentration range which caused inhibition of uptakel, increased the sensitivity to NA, while DMI, in a concentration range which inhibited uptake1, did not increase the sensitivity to NA and at high concentrations reduced the sensitivity and maximal response to NA. Since DMI affected responses to NA but not responses to vasopressin and potassium its effect is probably related to blockade of α1-adrenoceptors.4. We conclude that the effect of cocaine on the sensitivity to NA reflects inhibition of uptakel in rat resistance arteries, while DMI cannot be used to assess the functional effect of uptakel in this preparation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1994.tb02563.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Mechanical properties of vascular smooth muscle cells in situ (1976)
    [s.l.] : Nature Publishing Group
    Nature 260 (1976), S. 617-619 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 a, Sketch showing method of mounting vessel segment. The vessels were excised from the animal together with about 1 cm of the proximal arterial tree. The latter was threaded on to a 32-µm tungsten wire and used to guide the wire into the lumen of the test vessel. The unwanted tissue ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/260617a0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Active, passive and myogenic characteristics of isolated rat intramural coronary resistance arteries (1987)
    Springer
    Pflügers Archiv 410 (1987), S. 664-670 
    Details
    ISSN: 1432-2013
    Keywords: Coronary resistance vessel ; Mesenteric resistance vessel ; Length-tension relation ; Myogenic tone ; Histology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have investigated the active, passive and myogenic tension-internal circumference relations of rat intramural coronary and, as controls, mesenteric small arteries (internal diameter ca. 200 μm) using an isometric myograph. The active tensions of the vessels (when fully activated with 30 μM serotonin in K-saline) reached a maximum (2.54 N/m, coronary; 3.39 N/m, mesenteric) at an internal circumference, L0, where the passive tensions (measured in Ca-free solution) were 0.80 N/m (coronary) and 0.74 N/m (mesenteric). Below 0.8 L0 and above 1.2 L0 the active tensions fell linearly, the zero tension intercepts being 0.37 L0 and 1.74 L0 (coronary) and 0.40 L0 and 1.72 L0 (mesenteric). The passive wall tensions of the vessels rose exponentially as a function of internal circumference, the wall tension at 1.5 L0 being 10.0 N/m (coronary) and 8.5 N/m (mesenteric). In normal physiological salt solution, the coronary vessels had a Ca2+ dependent myogenic tone which was also dependent on the internal circumference. Maximum myogenic tone (0.54 N/m) was obtained at 1.18 L0. The mesenteric vessels had no such myogenic tone. Histological examination showed that the media/lumen ratios of both vessel types were the same, and that the smooth muscle content of the media was greater in the coronary (81%) than in the mesenteric (72%) vessels. The smaller active tension of the coronary vessels could not therefore be ascribed to a reduced smooth muscle content, but possibly in part to an observed heterogeneous arrangement of the smooth muscle cells in the coronary vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581329
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Differential contractile effects of changes in carbon dioxide tension on rat mesenteric resistance arteries precontracted with noradrenaline (1991)
    Springer
    Pflügers Archiv 419 (1991), S. 51-56 
    Details
    ISSN: 1432-2013
    Keywords: Arteries ; Contractility ; Norepinephrine ; Peripheral resistance ; pH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pH-sensitive dye 2′,7′-bis(2-carboxyethyl)- 5(and -6)-carboxyfluorescein (BCECF) was used to measure intracellular pH (pHi) in rat mesenteric resistance arteries (internal diameter 152–289 μm) mounted in an isometric myograph for simultaneous measurements of force. Extracellular pH was measured using a pH-sensitive electrode. Experiments were designed to test contractile effects of changes in carbon dioxide tension (PCO2) on vessels precontracted with noradrenaline. An acute increase in PCO2 caused acute intracellular acidification and potentiation of contractility. The longer-term effect, however, was recovery of intracellular pH and vaso-relaxation. Opposite changes in tension and intracellular pH were observed by decreasing PCO2. Qualitatively similar changes in contractility were observed in response to changes in pHi induced by NH4Cl. Thus, effects on vessels precontracted with noradrenaline were biphasic. In another set of experiments, the amplitude of the transient responses to 50 μM noradrenaline in calcium-free media was significantly augmented by an increase in the PCO2, whereas the response to 5 μM noradrenaline 1 min after readdition of calcium to the medium was depressed by the rise in PCO2. These data suggest that acute intracellular acidification causes acute tension development and are consistent with the possibility that the biphasic response to changes in noradrenaline-induced contractility caused by changes in PCO2 may be ascribed to differential effects on calcium mobilisation processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00373747
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Noradrenaline-induced depolarization is smaller in isobaric compared to isometric preparations of rat mesenteric small arteries (1996)
    Springer
    Pflügers Archiv 431 (1996), S. 794-796 
    Details
    ISSN: 1432-2013
    Keywords: rat mesenteric small artery ; smooth muscle ; noradrenaline ; membrane potential ; wall tension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hypothesis was tested that wall tension can influence the membrane potential response to noradrenaline (NA) using isometric and isobaric vessel preparations of rat mesenteric small arteries. The resting membrane potential was significantly less negative in the isobaric (−49.7±0.5 mV, S.E.M., n=12 vessels) compared to the isometric preparation (−56.1±0.7 mV, n=10), although there was no difference in wall tension. The depolarization induced by 10−5 M NA was 2.6-fold smaller in the isobaric preparation, where wall tension decreased, compared to the isometric preparation, where wall tension increased. Since wall tension decreases under isobaric conditions, but increases under isometric conditions, the latter finding can be explained by assuming that part of the NA-induced membrane potential change is wall tension dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253846
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Endogenous and exogenous agonist-induced changes in the coupling between [Ca2+]i and force in rat resistance arteries (1992)
    Springer
    Pflügers Archiv 420 (1992), S. 536-543 
    Details
    ISSN: 1432-2013
    Keywords: Arteries ; Calcium ; Cytosol ; Vasopressin ; Noradrenaline ; Fura-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between isometric tension and free cytoplasmic calcium, [Ca2+]i, was investigated in rat isolated resistance arteries using fura-2. Depolarisation with 125 mM K+ induced a tonic contraction, while [Ca2+]i increased transiently but stabilised above resting [Ca2+]i. Furthermore, the tension/[Ca2+]i ratio was lower during activation with 125 mM K+ if the effect of endogenous noradrenaline (NA) was inhibited. Concentration/ response curves with NA and K+ indicated that NA increased the sensitivity to [Ca2+]i. Calcium concentration/response curves in the presence of 10 μM NA or 125 mM K+ showed that NA could induce force at or below resting [Ca2+]i, while for any given bath calcium concentration, [Ca2+]i was similar in the presence of NA or K+. Addition of NA or vasopressin (AVP) to vessels depolarised with 125 mM K+ caused force development but no increase in [Ca2+]i, suggesting that agonists increase the efficacy of [Ca2+]i. However, during activation with AVP the efficacy of [Ca2+]i decreased time-dependently. The results suggest that in resistance arteries [Ca2+]i plays a crucial role in excitation-contraction coupling, but the tension/[Ca2+]i relationship can be modified by exogenous and endogenous agonists.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00374630
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Noradrenaline-induced depolarization is smaller in isobaric compared to isometric preparations of rat mesenteric small arteries (1996)
    Springer
    Pflügers Archiv 431 (1996), S. 794-796 
    Details
    ISSN: 1432-2013
    Keywords: Keywords: rat mesenteric small artery, smooth muscle, noradrenaline, membrane potential, wall tension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hypothesis was tested that wall tension can influence the membrane potential response to noradrenaline (NA) using isometric and isobaric vessel preparations of rat mesenteric small arteries. The resting membrane potential was significantly less negative in the isobaric (-49.7±0.5 mV, S.E.M., n=12 vessels) compared to the isometric preparation (-56.1±0.7 mV, n=10), although there was no difference in wall tension. The depolarization induced by 10-5 M NA was 2.6-fold smaller in the isobaric preparation, where wall tension decreased, compared to the isometric preparation, where wall tension increased. Since wall tension decreases under isobaric conditions, but increases under isometric conditions, the latter finding can be explained by assuming that part of the NA-induced membrane potential change is wall tension dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253846
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...