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  • 1
    Electronic Resource
    Electronic Resource
    Microarrayed recombinant allergens for diagnosis of allergy (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We suggest that the coapplication of recombinant allergens and microarray technology can lead to the development of new forms of multi-allergen tests which allow the determining and monitoring of complex sensitization profiles of allergic patients in single assays. The allergen extracts which have so far been used for diagnosis only allowed the determining of whether an allergic patient is sensitized against a particular allergen source, but the disease-eliciting allergens could not be identified. Through the application of recombinant DNA technology a rapidly growing panel of recombinant allergen molecules has become available which meanwhile comprises the epitope spectrum of most of the important allergen sources. We demonstrate that microarray technology can be used to establish multi-allergen tests consisting of microarrayed recombinant allergen molecules. Microarrayed recombinant allergens can be used to determine and monitor the profile of disease-eliciting allergens using single tests that require minute amounts of serum from allergic patients. The wealth of diagnostic information gained through microarray-based allergy testing will likely improve diagnosis, prevention and treatment of allergy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01550.x
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  • 2
    Electronic Resource
    Electronic Resource
    Allergen microarray: comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergen-specific serum immunoglobulin E (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background The availability of recombinant allergens and recent advances in biochip technology led to the development of a novel test system for the detection of allergen-specific IgE.Objective To test the performance of this allergen microarray in a serological analytical study.Methods Standard allergens contained in grass pollen (Phl p 1, Phl p 2, Phl p 5 and Phl p 6) and tree pollen (Bet v 1 and Bet v 2) were used as a model system. The detection of allergen-specific serum IgE using microarrays was compared with standard test systems: CAP/RAST and an in-house ELISA. In order to test the analytical sensitivity of the assays, geometric dilutions of a serum pool containing high levels of pollen-specific IgE from allergic individuals were tested in each system. To assess the analytical specificity, the sera of 51 patients with presumptive allergic symptoms were collected before diagnosis. Thereafter, the results for grass/tree-pollen-specific IgE were compared.Results The microarray has a good dynamic range similar to the CAP/RAST system. Microarray and ELISA showed comparable analytical sensitivity exceeding the CAP/RAST system. With respect to the analytical specificity, no significant cross-reactivity of the allergens was observed. For two of the allergens tested, weak positive signals were detected in the microarray test system, whereas they were not detectable by CAP/RAST.Conclusion A good correlation of presently used methods to detect serum IgE and the novel microarray test system was observed. As a next step, a careful validation of this method for a multitude of allergens and a thorough clinical evaluation has to be provided.Microarray testing of allergen-specific IgE can be presumed to be the method of choice for a prospective component-resolved diagnosis of Type I allergy, and the basis for the design and monitoring of a patient-tailored specific immunotherapy in the future.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01784.x
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  • 3
    Electronic Resource
    Electronic Resource
    Approximation properties of theM n -operators (1970)
    Springer
    Aequationes mathematicae 4 (1970), S. 268-270 
    Details
    ISSN: 1420-8903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01817774
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  • 4
    Electronic Resource
    Electronic Resource
    Approximation properties of theM n -operators (1970)
    Springer
    Aequationes mathematicae 5 (1970), S. 19-37 
    Details
    ISSN: 1420-8903
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01819267
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  • 5
    Electronic Resource
    Electronic Resource
    The state dependence of the interaction of metastable rare gas atoms Rg*(ms3 P 2,3 P 0) (Rg=Ne, Ar, Kr, Xe) with ground state sodium atoms (1990)
    Springer
    The European physical journal 16 (1990), S. 237-249 
    Details
    ISSN: 1434-6079
    Keywords: 31.20Pv ; 31.50.+w ; 31.70.−f ; 34.20.−b ; 34.50.Gb ; 35.20.Gs ; 82.40.Dm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Using crossed beams of metastable rare gas atoms Rg*(ms3 P 2,3 P 0) (Rg=Ne, Ar, Kr, Xe) and ground state sodium atoms Na(3s 2 S 1/2), we have measured the energy spectra of electrons released in the respective Penning ionization processes at thermal collision energies. For Rg*(3 P 2)+Na(3s), the spectra are quite similar for the different rare gases, both in width and shape; they reflect attractive interactions in the entrance channel with well depthsD* e [meV] decreasing slowly from Rg=Ne to Xe as follows: 676(18); 602(23); 565(26); 555(30). For Rg*(3 P 0)+Na(3s), the spectra vary strongly with the rare gas, indicating a change in the character of the interaction from van der Waals type attraction (Ne) to chemical binding for Kr and Xe with well depthsD* e [meV] of: 51(19); 107(25); 432(30); 530(50). These findings are explained through model calculations of the respective potential curves, in which the exchange and the spin orbit interaction in the excited rare gas and the molecular interaction between the two valences-electrons in terms of suitably chosen singlet and triplet potentials are taken into account. These calculations also explain qualitatively the experimental finding that the ratiosq 2/q 0 of the ionization cross sections for Rg*(3 P 2)+Na and Rg*(3 P 0)+Na vary strongly with the rare gas from Ne to Xe as follows: 15.8(3.2); 2.6(4); 1.4(2); 1.6(4).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01437526
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  • 6
    Electronic Resource
    Electronic Resource
    Experimental and theoretical studies of the Bi-excited collision systems He*(23 S) + He*(23 S, 21 S) at thermal and subthermal kinetic energies (1991)
    Springer
    The European physical journal 21 (1991), S. 89-112 
    Details
    ISSN: 1434-6079
    Keywords: 31.20.Di ; 34.50.Gb ; 52.20.Hv
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We have carried out a comprehensive experimental and theoretical investigation of the autoionizing collision systems He*(23 S, 21 S) + He*(23 S). We present high resolution electron energy spectra, obtained with a single He* beam (average relative collision energy 〈E rel〉=1.6 meV) and with crossed He* beams (〈E rel〉〉 =61 meV). The spectra show substantial structure, and under single beam conditions fast oscillations due to the interference of incoming and outgoing heavy particle waves in the entrance channels are observed. Accurate ab initio potential curves for the seven lowest He*—He*(Σ) molecular states have been obtained from a Feshbach projection scheme, and width functions for He*(23 S) + He*(23 S) have been derived by Stieltjes imaging. Based on these ab initio data, detailed quantum mechanical calculations of the electron spectra have been carried out and provide a thorough understanding of the experimentally observed spectral features. Good overall agreement of the calculated spectra with the experimental data is observed. The close coincidence in the positions of the experimental and theoretical peaks, especially for He*(23 S) + He*(23 S), underlines the reliability of the ab initio potentials. In the He*(21 S) + He*(23 S) electron spectrum, the dominant peak is traced to be due to autoionization from the 23Σ+ g molecular state accessed via an avoided crossing. We also present a detailed discussion of the total ionization cross sections σtot and of the fraction σAI/σtot for associative ionization together with a critical comparison with previous work. The ionization probabilities for close collisions in entrance channels, from which autoionization is spin-allowed, are near unity, and therefore the absolute values and the collision energy dependence of the total cross sections simply reflect the long-range behaviour of the excited state potentials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01425589
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  • 7
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    Polarization asymmetries in the ^{9} Be(γ,n_{0} ) reaction (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-09-11
    Description: Author(s): J. M. Mueller, M. W. Ahmed, B. J. Davis, H. J. Karwowski, D. M. Markoff, L. S. Myers, M. C. Spraker, S. Stave, J. R. Tompkins, H. R. Weller, and W. R. Zimmerman Measurements of the Be 9 ( γ , n 0 ) reaction were performed using nearly 100% linearly polarized, high-intensity, and nearly monoenergetic γ -ray beams having energies between 5.5 and 15.5 MeV at the High Intensity γ -ray Source located at Duke University and Triangle Universities Nuclear Laboratory. Eighte… [Phys. Rev. C 92, 034604] Published Thu Sep 10, 2015
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    Prompt neutron polarization asymmetries in photofission of Th232, U233,235,238, Np237, and Pu239,240 (2014)
    American Physical Society (APS)
    Details
    Publication Date: 2014-03-20
    Description: Author(s): J. M. Mueller, M. W. Ahmed, R. H. France, III, M. S. Johnson, H. J. Karwowski, L. S. Myers, J. Randrup, M. H. Sikora, M. C. Spraker, S. Stave, J. R. Tompkins, R. Vogt, H. R. Weller, C. S. Whisnant, and W. R. Zimmerman Photofission experiments were performed on targets of Th232, U233,235,238, Np237, and Pu239,240 using nearly 100% linearly polarized, high intensity (∼5×106γ/s), and nearly-monoenergetic γ-ray beams having energies between 5.3 and 7.6 MeV at the High Intensity γ-ray Source (HIγS) located at Duke Uni... [Phys. Rev. C 89, 034615] Published Wed Mar 19, 2014
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 9
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    Measurement of prompt neutron polarization asymmetries in photofission of ^{235,238}U, ^{239}Pu, and ^{232}Th (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-01-12
    Description: Author(s): J. M. Mueller, M. W. Ahmed, B. Davis, J. M. Hall, S. S. Henshaw, M. S. Johnson, H. J. Karwowski, D. Markoff, L. S. Myers, B. A. Perdue, S. Stave, J. R. Tompkins, M. J. Tuffley, and H. R. Weller [Phys. Rev. C 85, 014605] Published Wed Jan 11, 2012
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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