ISSN:
1420-9071
Keywords:
Marine sponges
;
muscarinic receptor
;
sceptrin
;
oroidin
;
dibromosceptrin
;
clathrodin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract In a search for potential target sites for C11N5 compounds obtained from marine sponges of the genusAgelas we evaluated their interaction with muscarinic acetylcholine receptors from rat brain membranes. In competition experiments with3H-QNB these compounds displayed the following rank order of potency: sceptrin〉oroidin≥dibromosceptrin≥clathrodin. Sceptrin (50 μM) was shown to be a competitive inhibitor of3H-QNB binding as revealed by Scatchard analysis. The results demonstrate the ability of these compounds to interact with multiple target molecules in the micromolar range.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02118426
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