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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diseases of the colon & rectum 35 (1992), S. 462-464 
    ISSN: 1530-0358
    Keywords: Rectum ; Anastomosis ; Internal anal sphincter ; Anal resting pressure ; Anorectal manometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been postulated that reduction in anal resting pressure following low anterior resection is due to intraoperative injury to the internal anal sphincter during transanal passage of the stapling device or damage to its nerve supply in the course of rectal mobilization. The aim of this study was to assess the relative importance of either mechanism. Fourteen dogs had a standard segment of colon and distal rectum excised. Colorectal reconstruction was performed using either a low stapled EEA® (U.S. Surgical Corporation, Norwalk, CT) colorectal anastomosis (n=7) or a handsewn anastomosis (n=7). Anorectal manometry was performed preoperatively and again on the 10th postoperative day. Resting anal pressure was significantly reduced after EEA® anastomosis (mean±SEM: before, 49±3 mm Hg; after, 20±4 mm Hg; P 〈0.001) and handsewn anastomosis (mean±SEM: before, 46±4 mm Hg; after, 35±4 mm Hg; P〈0.01). Postoperative resting pressures were also significantly reduced (P〈0.05) following EEA® anastomosis when compared with the handsewn group. This study suggests that damage to the innervation of the internal anal sphincter during rectal mobilization and further direct injury to the sphincter during transanal instrumentation both contribute to the fall in anal resting pressure observed following low anterior resection.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1434-0879
    Keywords: Partial ureteric obstruction ; Blood flow Prostaglandins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Haemodynamic changes in partial unilateral ureteric obstruction (PUUO) may be related to altered prostaglandin synthesis. In 12 dogs the left ureter was partially obstructed for 5 weeks. In six dogs the ureter was reimplanted into the bladder and to investigate the effect of this procedure on the contralateral side the other six animals underwent ipsilateral nephroureterectomy. Renal blood flow (RBF) was measured by the distribution of radiolabelled microspheres. Changes in urinary prostaglandin (PG) concentrations were validated by renin activity using angiotensin I. Reduced left RBF during obstruction was associated with increased thromboxane A2 synthesis (P〈0.01). Increased RBF to the nonobstructed side was associated with elevated PGE2 formation (P〈0.05). Elevated angiotensin I levels (P〈0.01) corresponded to maximal increases in PG synthesis. Reimplantation of the obstructed kidney did not exert a direct effect on contralateral RBF or PG concentration. Haemodynamic changes in PUUO in vivo are associated with alterations in renal PGs.
    Type of Medium: Electronic Resource
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