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  • 1
    Publication Date: 2022-05-25
    Description: Author Posting. © The Author(s), 2018. This is the author's version of the work. It is posted here under a nonexclusive, irrevocable, paid-up, worldwide license granted to WHOI. It is made available for personal use, not for redistribution. The definitive version was published in Earth and Planetary Science Letters 489 (2018): 49-58, doi:10.1016/j.epsl.2018.02.025.
    Description: A long-standing conceptual model for deep submarine eruptions is that high hydrostatic pressure hinders degassing and acceleration, and suppresses magma fragmentation. The 2012 submarine rhyolite eruption of Havre volcano in the Kermadec arc provided constraints on critical parameters to quantitatively test these concepts. This eruption produced a 〉 1 km3 raft of floating pumice and a 0.1 km3 field of giant (〉1 m) pumice clasts distributed down-current from the vent. We address the mechanism of creating these clasts using a model for magma ascent in a conduit. We use water ingestion experiments to address why some clasts float and others sink. We show that at the eruption depth of 900 m, the melt retained enough dissolved water, and hence had a low enough viscosity, that strain-rates were too low to cause brittle fragmentation in the conduit, despite mass discharge rates similar to Plinian eruptions on land. There was still, however, enough exsolved vapor at the vent depth to make the magma buoyant relative to seawater. Buoyant magma was thus extruded into the ocean where it rose, quenched, and fragmented to produce clasts up to several meters in diameter. We show that these large clasts would have floated to the sea surface within minutes, where air could enter pore space, and the fate of clasts is then controlled by the ability to trap gas within their pore space. We show that clasts from the raft retain enough gas to remain afloat whereas fragments from giant pumice collected from the seafloor ingest more water and sink. The pumice raft and the giant pumice seafloor deposit were thus produced during a clast-generating effusive submarine eruption, where fragmentation occurred above the vent, and the subsequent fate of clasts was controlled by their ability to ingest water.
    Description: MM, KF, CL and BH are supported by NSF 1447559. SM and BH are supported by NSF 1357443. RJC was funded by the Australian Research Council (DP110102196, DE150101190). AS is supported by NSF 1357216. MJ is supported by a National Defense Science and Engineering Graduation Fellowship. Additional support was provided by the Marsden fund and the 2017 Student Mentoring and Research Teams (SMART) Program, Graduate Division, University of California, Berkeley.
    Keywords: Submarine eruption ; Pumice ; Fragmentation ; Raft ; Conduit flow ; Xray tomography
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
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  • 2
    Publication Date: 2023-03-02
    Description: Author Posting. © Society for Neuroscience, 2023. This article is posted here by permission of Society for Neuroscience for personal use, not for redistribution. The definitive version was published in The Journal of Neuroscience 43(1), (2023): 2-13, https://doi.org/10.1523/JNEUROSCI.2484-21.2022.
    Description: A question relevant to nicotine addiction is how nicotine and other nicotinic receptor membrane-permeant ligands, such as the anti-smoking drug varenicline (Chantix), distribute in brain. Ligands, like varenicline, with high pKa and high affinity for α4β2-type nicotinic receptors (α4β2Rs) are trapped in intracellular acidic vesicles containing α4β2Rs in vitro. Nicotine, with lower pKa and α4β2R affinity, is not trapped. Here, we extend our results by imaging nicotinic PET ligands in vivo in male and female mouse brain and identifying the trapping brain organelle in vitro as Golgi satellites (GSats). Two PET 18F-labeled imaging ligands were chosen: [18F]2-FA85380 (2-FA) with varenicline-like pKa and affinity and [18F]Nifene with nicotine-like pKa and affinity. [18F]2-FA PET-imaging kinetics were very slow consistent with 2-FA trapping in α4β2R-containing GSats. In contrast, [18F]Nifene kinetics were rapid, consistent with its binding to α4β2Rs but no trapping. Specific [18F]2-FA and [18F]Nifene signals were eliminated in β2 subunit knock-out (KO) mice or by acute nicotine (AN) injections demonstrating binding to sites on β2-containing receptors. Chloroquine (CQ), which dissipates GSat pH gradients, reduced [18F]2-FA distributions while having little effect on [18F]Nifene distributions in vivo consistent with only [18F]2-FA trapping in GSats. These results are further supported by in vitro findings where dissipation of GSat pH gradients blocks 2-FA trapping in GSats without affecting Nifene. By combining in vitro and in vivo imaging, we mapped both the brain-wide and subcellular distributions of weak-base nicotinic receptor ligands. We conclude that ligands, such as varenicline, are trapped in neurons in α4β2R-containing GSats, which results in very slow release long after nicotine is gone after smoking.
    Description: This work was supported in part by National Institutes of Health (NIH) Grants R01 DA044760-01 (to J.M., C.-T.C. and W.N.G.), RF1 AG029479 (to J.M.), and T32 DA043469 (to M.Z.). The authors acknowledge the assistance from the Integrative Small Animal Imaging Research Resources (iSAIRR) supported in part by NIH Grants P30 CA14500 and S10 OD025265 and from the Cyclotron Facility of the University of Chicago.
    Description: 2023-07-04
    Keywords: Addiction ; Fluorescence ; Mouse model ; Nicotine ; Positron emission tomography ; Smoking cessation
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 3
    Publication Date: 2022-05-26
    Description: © The Author(s), 2019. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Mitchell, S. J., Houghton, B. F., Carey, R. J., Manga, M., Fauria, K. E., Jones, M. R., Soule, S. A., Conway, C. E., Wei, Z., & Giachetti, T. Submarine giant pumice: A window into the shallow conduit dynamics of a recent silicic eruption. Bulletin of Volcanology, 81(7), (2019): 42, doi:10.1007/s00445-019-1298-5.
    Description: Meter-scale vesicular blocks, termed “giant pumice,” are characteristic primary products of many subaqueous silicic eruptions. The size of giant pumices allows us to describe meter-scale variations in textures and geochemistry with implications for shearing processes, ascent dynamics, and thermal histories within submarine conduits prior to eruption. The submarine eruption of Havre volcano, Kermadec Arc, in 2012, produced at least 0.1 km3 of rhyolitic giant pumice from a single 900-m-deep vent, with blocks up to 10 m in size transported to at least 6 km from source. We sampled and analyzed 29 giant pumices from the 2012 Havre eruption. Geochemical analyses of whole rock and matrix glass show no evidence for geochemical heterogeneities in parental magma; any textural variations can be attributed to crystallization of phenocrysts and microlites, and degassing. Extensive growth of microlites occurred near conduit walls where magma was then mingled with ascending microlite-poor, low viscosity rhyolite. Meter- to micron-scale textural analyses of giant pumices identify diversity throughout an individual block and between the exteriors of individual blocks. We identify evidence for post-disruption vesicle growth during pumice ascent in the water column above the submarine vent. A 2D cumulative strain model with a flared, shallow conduit may explain observed vesicularity contrasts (elongate tube vesicles vs spherical vesicles). Low vesicle number densities in these pumices from this high-intensity silicic eruption demonstrate the effect of hydrostatic pressure above a deep submarine vent in suppressing rapid late-stage bubble nucleation and inhibiting explosive fragmentation in the shallow conduit.
    Description: This study was funded primarily through an NSF Ocean grant: OCE-1357443 (SJM, BFH and RJC). MM is supported by NSF EAR 1447559. The μXRT analysis was performed at the Lawrence Berkeley National Lab Advanced Light Source beamline 8.3.2 and the large CT scan by SAS at the University of Texas Austin micro-CT facility. Capillary flow porometry and He-pycnometry were assisted by TG and MRJ at the University of Oregon. Microprobe analysis was conducted at the University of Hawai’i at Mānoa. CEC was supported by post-doctoral research fellowship from the Japan Society for the Promotion of Science (JSPS16788). We would like to thank Kenichiro Tani, Takashi Sano, and Eric Hellebrand for their assistance with geochemical data acquisition, JoAnn Sinton and Wagner Petrographic for thin section preparation, Zachary Langdalen for binary processing of BSE images, Warren M. McKenzie for measuring clast densities, and Dula Parkinson for guidance with the μXRT imaging. We further acknowledge the full scientific team, crew and Jason ROV team (Woods Hole Oceanographic Institute) aboard the R/V Roger Revelle (Scripps Institute of Oceanography) during the MESH expedition in 2015, without whom, this study would not have been possible. Finally, we thank Andrew Harris, Katharine Cashman, Lucia Gurioli and an anonymous reviewer for their insightful and helpful reviews of the manuscript.
    Keywords: Giant pumice ; Submarine volcanism ; Banding ; Tube pumice ; Bubble deformation ; Conduit dynamics
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 4
    Publication Date: 2023-02-08
    Description: Deep-water volcanoes are emplaced in water depths 〉1.0 km and are widespread along continental margins and in ocean basins. Whilst the external morphology of deep-water volcanoes can be mapped using bathymetric surveys, their internal structure and true volume remain enigmatic. It is thus difficult to determine how deep-water volcanoes grow. We investigate 13 Late Miocene-to-Quaternary, deep-water volcanoes that are imaged in 3D by seismic reflection data from the northern South China Sea, which allow us to quantify their external morphology and examine their internal structure. These deep-water volcanoes were emplaced in water depths 〉1.5 km, are relatively small (〈3.0 km diameter, 〈0.56 km tall, and 〈0.92 km3 in volume), and have steep slopes (up to 42°). Most of the volcanoes have erosional, ‘crater-like’ bases, infilled with sub-horizontal seismic reflections. These crater-like bases are overlain by downward-converging, conical seismic reflections delineating the classical volcano morphology. We suggest the crater-like bases formed by excavation of cold, wet, and poorly consolidated near-seabed sediment during expulsion of hydrothermal fluid, and not by explosive magmatic eruptions or gravitational subsidence. Erupted igneous material infilled the precursor craters with the observed sub-horizontal layers, likely comprising hyaloclastites. After this initial phase of volcanism, the buildup of volcanic material produced layers that are now represented by the flank-parallel or downward-converging, conical seismic reflections. We suggest high hydrostatic pressures of 〉15 MPa, which are typical of water depths 〉1.5 km, inhibited degassing and fragmentation of ascending magma and thus erupted lava. This lack of degassing and fragmentation permitted effusive eruptions during the latter stages of volcanism. Our models for volcano growth in the deep submarine realm demonstrate the power of using 3D seismic data when investigating the internal structure and total volume of deep-water volcanoes.
    Type: Article , PeerReviewed
    Format: text
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