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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 30 (1974), S. 649-652 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Bei einem Individuum mit Multipler Sklerose, Psoriasis und Arthritis konnte man bei elektronenmikroskopischer Kontrolle von Synovialgewebe des Knies feine Filopodien nachweisen, die wahrscheinlich an der Aufnahme von Zellfragmenten, Fibrin und Erythrozyten im Gelenkspalt beteiligt sind.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 92 (1933), S. 306-306 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
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    Royal Meteorological Society
    In:  Quarterly Journal of the Royal Meteorological Society, 141 (692). pp. 2670-2689.
    Publication Date: 2017-12-19
    Description: A multiple linear regression statistical method is applied to model data taken from the Coupled Model Intercomparison Project, phase 5 (CMIP-5) to estimate the 11-yr solar cycle responses of stratospheric ozone, temperature, and zonal wind during the 1979-2005 period. The analysis is limited to the six CMIP-5 models that resolve the stratosphere (high-top models) and that include interactive ozone chemistry. All simulations assumed a conservative 11-yr solar spectral irradiance (SSI) variation based on the NRL model. These model responses are then compared to corresponding observational estimates derived from two independent satellite ozone profile data sets and from ERA Interim Reanalysis meteorological data. The models exhibit a range of 11-yr responses with three models (CESM1-WACCM, MIROC-ESM-CHEM, and MRI-ESM1) yielding substantial solar-induced ozone changes in the upper stratosphere that compare favorably with available observations. The remaining three models do not, apparently because of differences in the details of their radiation and photolysis rate codes. During winter in both hemispheres, the three models with stronger upper stratospheric ozone responses produce relatively strong latitudinal gradients of ozone and temperature in the upper stratosphere that are associated with accelerations of the polar night jet under solar maximum conditions. This behavior is similar to that found in the satellite ozone and ERA Interim data except that the latitudinal gradients tend to occur at somewhat higher latitudes in the models. The sharp ozone gradients are dynamical in origin and assist in radiatively enhancing the temperature gradients, leading to a stronger zonal wind response. These results suggest that simulation of a realistic solar-induced variation of upper stratospheric ozone, temperature and zonal wind in winter is possible for at least some coupled climate models even if a conservative SSI variation is adopted.
    Type: Article , PeerReviewed
    Format: text
    Format: text
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  • 4
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    Unknown
    Royal Meteorological Society
    In:  Quarterly Journal of the Royal Meteorological Society, 141 (691). pp. 2390-2403.
    Publication Date: 2017-12-19
    Description: The 11-year solar cycle component of climate variability is assessed in the historical simulations of models taken from the Coupled Model Inter-comparison Project, phase 5 (CMIP-5). Multiple linear regression is applied to estimate the zonal-temperature, −wind and annular mode responses to a typical solar cycle, with a focus on both the stratosphere and the stratospheric influence on the surface over the period ∼1850-2005. The analysis is performed on all CMIP-5 models, but focuses on the 13 CMIP-5 models that resolve the stratosphere (high-top models), and compares the simulated solar cycle signature with reanalyses data. The 11-year solar cycle component of climate variability is found to be weaker in terms of magnitude and latitudinal gradient around the stratopause in the models than in reanalysis. The peak in temperature in the lower equatorial stratosphere (∼70 hPa) reported in some studies is found in the models to depend on the length of the analysis period, with the last 30 years yielding the strongest response. A modification of the Polar Jet Oscillation (PJO) in response to the 11-year solar cycle is not robust across all models, but is more apparent in models with high spectral resolution in the shortwave. The PJO evolution is slower in the models, leading to a stronger response during February, whereas observations indicate it to be weaker. In early winter, the magnitudes of the modelled response is more consistent with observations when only data from 1979–2005 is considered. The observed North Pacific high-pressure surface response during solar maximum is only simulated in some models, of which there are no distinguishing model characteristics. The lagged North Atlantic surface response is reproduced in both high- and low-top models, but is more prevalent in the former. In both cases, the magnitude of the response is generally lower than in observations.
    Type: Article , PeerReviewed
    Format: text
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  • 5
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    Unknown
    Royal Meteorological Society
    In:  Quarterly Journal of the Royal Meteorological Society, 142 (Part B). pp. 928-941.
    Publication Date: 2019-02-01
    Description: The surface response to the 11-yr solar cycle is assessed in ensemble simulations of the 20th century climate performed in the framework of the 5th phase of the Coupled Model Inter-Comparison Project (CMIP5). A lead/lag multiple linear regression analysis identifies a multi-model mean (MMM) global mean surface warming of about 0.07 K lagging the solar cycle by one to two years on average. The anomalous warming penetrates to approximately the first 80–100 m depth in the ocean. Solar signals in the troposphere show a similar time lag of one to two years and the strongest MMM warming is simulated in the tropics above 300 hPa. At the surface, the MMM response in a subset of models that show statistically significant global mean warming (CMIP5-SIG95) is characterized by an anomalous warming in the west equatorial Pacific Ocean and the Arctic, at one to two years after solar maximum. The Arctic warming is twice as strong as the global mean response and appears in winter months only. The surface warming in the equatorial Pacific Ocean is related to dynamical/thermodynamical processes. Different increase rates of global mean precipitation and atmospheric water vapor in response to a warmer surface lead to a weaker Walker circulation and anomalous westerly winds over the equatorial Pacific in years following solar maximum. Owing to atmosphere–ocean coupling, the anomalous westerly winds cool the subsurface and warm the surface in the western equatorial Pacific by ∼ 0.14 K. The CMIP5-SIG95 MMM surface warming in the equatorial Pacific and Arctic is weak but qualitatively similar compared to solar signals in the HadCRUT4 dataset.
    Type: Article , PeerReviewed
    Format: text
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  • 6
    Publication Date: 2013-03-23
    Description: IL-2 signals during the primary response to infection are essential in shaping CD8 + T cell fate decisions. How CD8 + T cells integrate IL-2 signals in the development of functional memory is not well understood. Because IL-2 induces potent activation of the STAT5 transcription factor, we tested the role of STAT5 in CD8 + memory T cell differentiation and function using a model system in which STAT5 activity is inducibly abrogated upon CD8 + T cell activation. We report that STAT5 activity is broadly important for the expansion and effector function of all effector CTL subsets. After pathogen clearance, STAT5 was required for the survival of effector phenotype memory CTLs during the contraction phase. However, despite its role in supporting full primary CD8 + T cell expansion, and unlike IL-2, STAT5 activity is not required for the development of memory CD8 + T cells capable of robust secondary expansion upon rechallenge. Our findings highlight differential requirements for survival signals between primary and secondary effector CTL, and demonstrate that IL-2–dependent programming of memory CD8 + T cells capable of secondary expansion and secondary effector differentiation is largely STAT5 independent.
    Print ISSN: 0022-1767
    Electronic ISSN: 1550-6606
    Topics: Medicine
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