ISSN:
1573-4919
Keywords:
vanadium salts
;
insulin action
;
cytosolic protein tyrosine kinase
;
protein phosphotyrosine phosphatase
;
molybdate—permolybdate
;
tungstate—pertungstate
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Most or all mammalian cells contain vanadium at a concentration of 0.1–1.0 μM. The bulk of the vanadium in cells is probably in the reduced vanadyl (IV) form. Although this element is essential and should be present in the diet in minute quantities, no known physiological role for vanadium has been found thus far. In the years 1975–1980 the vanadate ion was shown to act as an efficient inhibitor of Na+,K+-ATPase and of other related phosphohydrolyzes as well. In 1980 it was observed that vanadate vanadyl, when added to intact rat adipocytes, mimics the biological actions of insulin in stimulating hexose uptake and glucose oxidation. This initiated a long, currently active, field of research among basic scientists and diabetologists. Several of the aspects studied are reviewed here.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01075917
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