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  • 1
    Electronic Resource
    Electronic Resource
    ANTIGEN—ANTIBODY CROSSED ELECTROPHORESIS OF WATER-SOLUBLE RAT BRAIN ANTIGENS (1971)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A method of separation by antigen-antibody crossed electrophoresis was applied to the study of water-soluble rat brain antigens. Five different rat brain preparations were used as antigens for immunization. The extract from Triton X-100 treated brains gave the best antibody response. An antiserum containing 27 precipitating antibodies was obtained. The preparation of antigens for immunoelectrophoresis was investigated. Treatment with demineralized water gave the highest number of antigen-antibody precipitates. Treatment with detergents and sonication gave a higher total protein yield, but the number of precipitates was unaffected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1971.tb00199.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    BRAIN GLYCOGEN AFTER INTRACISTERNAL INSULIN INJECTION (1969)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 16 (1969), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Intracisternal injection of 0·1 i.u. of insulin to rats caused an increase in the brain glycogen content. Intravenous and intraperitoneal injection of the same amount had no effect on brain glycogen. The increase after intracisternal injection was first observed after 3–4 hr.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1969.tb06456.x
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  • 3
    Electronic Resource
    Electronic Resource
    3H-imipramine high-affinity binding sites in rat brain. Effects of imipramine and lithium (1982)
    Springer
    Psychopharmacology 77 (1982), S. 94-97 
    Details
    ISSN: 1432-2072
    Keywords: 3H-imipramine binding site ; Imipramine ; Lithium ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The specific high-affinity binding of 3H-imipramine to rat brain membranes was investigated. Five weeks of lithium treatment decreased the number of binding sites, but had no effect on the affinity constants. Long-term imipramine treatment had no effect on the number of binding sites but apparently decreased the affinity. The latter effect was probably due to imipramine remaining in the membrane preparation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00436105
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  • 4
    Electronic Resource
    Electronic Resource
    Endocytotic formation of rat brain synaptic vesicles (1974)
    [s.l.] : Nature Publishing Group
    Nature 249 (1974), S. 770-771 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have investigated whether synaptic vesicles could be labelled after intracerebral injection of a marker protein. Rats were injected intracisternally with bovine serum albumin (BSA) and after isolation of the synaptic vesicle fraction and specific quantitative assay of its BSA content, the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/249770a0
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  • 5
    Electronic Resource
    Electronic Resource
    Twelve-hour brain lithium concentration in lithium maintenance treatment of manic-depressive disorder: daily versus alternate-day dosing schedule (1996)
    Springer
    Psychopharmacology 124 (1996), S. 275-278 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Brain lithium concentration ; Dosing schedule ; Manic-depressive disorder ; Lithium-7 magnetic resonance spectroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The 12-h brain lithium concentration was measured by lithium-7 magnetic resonance spectroscopy in ten manic-depressive patients receiving daily or alternate-day lithium carbonate treatment. The median dose of lithium carbonate was 800 mg in the daily treatment group and 1200 mg in the alternate-day group. Median 12-h serum lithium concentration in the two groups was 0.86 mmoll−1 and 0.55 mmoll−1, respectively, while the corresponding concentration in brain was 0.67 mmoll−1 and 0.52 mmoll−1, respectively. The 12-h brain lithium concentration was independent of lithium dosing schedule (multiple linear regression), but correlated significantly with the 12-h serum lithium concentration (P=0.003; B=0.53, 95% c.l. 0.24–0.82; β=0.83). Thus at identical 12-h serum lithium concentrations the 12-h brain lithium concentration is similar with both treatment regimes. As the risk of manic-depressive relapse during alternate-day lithium treatment is in our experience 3-fold greater than with daily treatment (at similar mean 12-h serum lithium concentration), the findings suggest that the difference in the prophylactic efficacy of the two dosing schedules is unrelated to differences in the 12-h brain lithium concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246668
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  • 6
    Electronic Resource
    Electronic Resource
    Lithium effects on serum calcium, magnesium and phosphate, in rats (1976)
    Springer
    Psychopharmacology 49 (1976), S. 187-190 
    Details
    ISSN: 1432-2072
    Keywords: Lithium ; Serum ; Calcium ; Magnesium ; Calcitonin and Parathormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary LiCl was injected daily to rats in a dose of 3 mmol/kg. The rats were, in different experiments, unoperated rats, parathyroidectomized rats and thyroparathyroidectomized rats. Serum concentrations of calcium, magnesium, and phosphate were measured 2 h after a lithium injection. Serum calcium was unaffected by lithium in unoperated and parathyroidectomized rats. In thyroparathyroidectomized rats lithium increased the serum calcium concentration. Serum magnesium was increased by lithium in all 3 groups of rats. Serum phosphate was slightly decreased by lithium in all 3 groups of rats. It is concluded that lithium increases both serum calcium and magnesium, but in the intact organism only a slight or no increase in serum calcium is seen after lithium due to physiological control mechanisms. After removal of the calcitonin producing C-cells in the thyroid gland the organism is unable to produce a fast decrease in serum calcium, and lithium is then able to increase the serum calcium concentration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427288
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