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  • 1
    Electronic Resource
    Electronic Resource
    INTRACELLULAR AND EXTRACELLULAR CALCIUM IONS IN TRANSMITTER RELEASE AT THE NEUROMUSCULAR SYNAPSE (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 307 (1978), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1978.tb41983.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Differentiated neuroblastoma cells are more susceptible to aluminium toxicity than developing cells (1989)
    Springer
    Archives of toxicology 63 (1989), S. 231-237 
    Details
    ISSN: 1432-0738
    Keywords: Aluminium ; Neurotoxicity ; Neuroblastoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of aluminium (20–50 μg/ml) on neuronal function was examined using electrophysiological techniques and neuroblastoma clone cells which offer a convenient model of differentiating and fully active neurons. Two specific questions were addressed: 1) Can differentiated cells maintain their normal excitable function when exposed to aluminium? 2) Can proper development of electrophysiological properties be achieved in its presence? We report that aluminium caused premature onset of deterioration in fully differentiated cells. Within 4–6 days they depolarized from −29.3+-0.9 mV to levels lower than −15 mV; compound polyphasic action potentials were gradually replaced by slow monophasic spikes before the final loss of excitable properties and structural deformations was noticed. Developing cells followed the normal pattern of differentiation in the presence of aluminium: within 7 days they extended neurites, hyperpolarized and exhibited polyphasic spikes. These results show that neuroblastoma cells are apparently less susceptible to aluminium's toxicity during the process of development than after differentiation. Possible mechanisms by which aluminium may exert its effects are discussed in view of these observations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316374
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  • 3
    Electronic Resource
    Electronic Resource
    Aluminium modifies the electrical response of neuroblastoma cells to a short hypertonic pulse (1992)
    Springer
    Archives of toxicology 66 (1992), S. 90-94 
    Details
    ISSN: 1432-0738
    Keywords: Aluminium ; Neurotoxicity ; Neuroblastoma ; Hypertonicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of aluminium (50–100 μg/ml) on the electrical response of N1E-115 neuroblastoma cells to a short hypertonic pulse was examined using conventional electrophysiological techniques and computer assisted analysis. Application of a small dose of hypertonic solution in the vicinity of the cell evoked depolarization of the membrane potential and a biphasic change in input resistance: an initial increase followed by a profound decrease. Upon washout of the hypertonic stimulus, repolarization of membrane potential and complete recovery of the input resistance were observed. In the presence of aluminium application of hypertonic solution had a reversible effect which showed a prolonged duration of the response without a change in its amplitude. It is suggested that the retardation in recovery from hypertonically induced shock may be due to rigidification of the plasma membrane in the presence of aluminium. Possible implications to human diseases associated with accumulation of aluminium in brain tissue are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02342500
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