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  • 1
    Online Resource
    Online Resource
    London :Palgrave Macmillan UK,
    Keywords: Human Geography. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (204 pages)
    Edition: 1st ed.
    ISBN: 9780230281172
    Language: English
    Note: Cover -- Contents -- Foreword -- List of Contributors -- Introduction -- Part I: Driving the Mobile -- 1 Contextualising and Mobilising Research -- 2 Mixing Methods in the Search for Mobile Complexity -- 3 In-vivo Sampling of Naive Drivers: Benefits, Practicalities and Ethical Considerations -- 4 Narrating Mobile Methodologies: Active and Passive Empiricisms -- Part II: Steering the Mobile -- 5 Liverpool Musicscapes: Music Performance, Movement and the Built Urban Environment -- 6 Vim de Bahia pra lhe ver: Multiple Movements in the Capoeira Batizado -- 7 Being There/Seeing There: Recording and Analysing Life in the Car -- 8 Writing Mobility: Australia's Working Holiday Programme -- 9 Catching a Glimpse: The Value of Video in Evoking, Understanding and Representing the Practice of Cycling -- 10 Have Backpack Will Travel: Auto/biography as a Mobile Methodology -- Conclusions: Mobilising Methodologies -- Bibliography -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W.
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Geoforum 14 (1973), S. 98 
    ISSN: 0016-7185
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geography
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Geoforum 14 (1973), S. 98 
    ISSN: 0016-7185
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geography
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Geoforum 14 (1973), S. 98 
    ISSN: 0016-7185
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geography
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Geoforum 14 (1973), S. 98 
    ISSN: 0016-7185
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geography
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Transport in porous media 8 (1992), S. 99-131 
    ISSN: 1573-1634
    Keywords: Characteristic ; wavespeed ; shock ; expansion fan ; Rankine-Hugoniot equations ; entropy inequality ; two-phase flow ; counterflow ; saturation ; pressure ; convection ; diffusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Technology
    Notes: abstract New concepts are introduced to describe single-component two-phase flow under gravity. The phases can flow simultaneously in opposite directions (counterflow), but information travels either up or down, depending on the sign of the wavespeedC. Wavespeed, saturation and other quantities are defined on a two-sheeted surface over the mass-energy flow plane, the sheets overlapping in the counterflow region. A saturation shock is represented as an instantaneous displacement along a line of constant volume fluxJ Q in the flow plane. Most shocks are of the wetting type, that is, they leave the environment more saturated after their passage. When flow is horizontal all shocks are wetting, but it is a feature of vertical two-phase flow that for sufficiently small mass and energy flows there also exist drying shocks associated with lower final saturations.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-1634
    Keywords: Geothermal heat pipe ; upstreaming, stability ; solution selection ; boundary conditions ; steady state ; two-phase counterflow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Technology
    Notes: Abstract In a geothermal reservoir, the heat pipe mechanism can transfer heat very efficiently, with vapor rising and liquid falling in comparable quantities, driven by gravity. For a given heat and mass flux that is not too large, there are two possible steady solutions with vapor-liquid counterflow, one liquid-dominated, and one vapor-dominated. Numerical solution of the equations for two-phase vertical counterflow displays intriguing stability behaviour. If pressure and saturation are fixed at depth, and heat and mass flux specified at the top, the vapor-dominated solution is almost always obtained. That is, for a variety of boundary values, the solution settles to the vapor-dominated steady-state, and only for very special values is it possible to obtain the liquid-dominated case. Similarly the liquid-dominated solution is almost always obtained if the boundary conditions are reversed, with pressure and saturation fixed at the top and heat and mass flux specified at depth. This behaviour is here explained in two complementary ways. It is shown to be a consequence of upstream differencing of the flow terms in the numerical method. It is also shown to be expected behaviour for wavelike saturation solutions. Hence the observed behaviour is not only a direct consequence of the numerical method used, but is fundamental to geothermal heat pipes.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Transport in porous media 7 (1992), S. 223-253 
    ISSN: 1573-1634
    Keywords: Characteristic ; wavespeed ; shock ; expansion fan ; Rankine-Hugoniot equations ; entropy inequality ; two-phase flow ; saturation ; pressure ; geothermal ; convection ; diffusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Technology
    Notes: Abstract In the absence of capillarity the single-component two-phase porous medium equations have the structure of a nonlinear parabolic pressure (equivalently, temperature) diffusion equation, with derivative coupling to a nonlinear hyperbolic saturation wave equation. The mixed parabolic-hyperbolic system is capable of substaining saturation shock waves. The Rankine-Hugoniot equations show that the volume flux is continuous across such a shock. In this paper we focus on the horizontal one-dimensional flow of water and steam through a block of porous material within a geothermal reservoir. Starting from a state of steady flow we study the reaction of the system to simple changes in boundary conditions. Exact results are obtainable only numerically, but in some cases analytic approximations can be derived. When pressure diffusion occurs much faster than saturation convection, the numerical results can be described satisfactorily in terms of either saturation expansion fans, or isolated saturation shocks. At early times, pressure and saturation profiles are functionally related. At intermediate times, boundary effects become apparent. At late times, saturation convection dominates and eventually a steady-state is established. When both pressure diffusion and saturation convection occur on the same timescale, initial simple shock profiles evolve into multiple shocks, for which no theory is currently available. Finally, a parameter-free system of equations is obtained which satisfactorily represents a particular case of the exact equations.
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 2012-09-14
    Description: Various small molecule pharmacologic agents with different known functions produce similar outcomes in diverse Mendelian and complex disorders, suggesting that they may induce common cellular effects. These molecules include histone deacetylase inhibitors, 4-phenylbutyrate (4PBA) and trichostatin A, and two small molecules without direct histone deacetylase inhibitor activity, hydroxyurea (HU) and sulforaphane. In some cases, the therapeutic effects of histone deacetylase inhibitors have been attributed to an increase in expression of genes related to the disease-causing gene. However, here we show that the pharmacological induction of mitochondrial biogenesis was necessary for the potentially therapeutic effects of 4PBA or HU in two distinct disease models, X-linked adrenoleukodystrophy and sickle cell disease. We hypothesized that a common cellular response to these four molecules is induction of mitochondrial biogenesis and peroxisome proliferation and activation of the stress proteome, or adaptive cell survival response. Treatment of human fibroblasts with these four agents induced mitochondrial and peroxisomal biogenesis as monitored by flow cytometry, immunofluorescence and/or western analyses. In treated normal human fibroblasts, all four agents induced the adaptive cell survival response: heat shock, unfolded protein, autophagic and antioxidant responses and the c-jun N -terminal kinase pathway, at the transcriptional and translational levels. Thus, activation of the evolutionarily conserved stress proteome and mitochondrial biogenesis may be a common cellular response to such small molecule therapy and a common basis of therapeutic action in various diseases. Modulation of this novel therapeutic target could broaden the range of treatable diseases without directly targeting the causative genetic abnormalities.
    Print ISSN: 0964-6906
    Electronic ISSN: 1460-2083
    Topics: Biology , Medicine
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  • 10
    Publication Date: 2013-03-29
    Description: The p21-activated kinases (Paks) are serine/threonine kinases that are major effectors of the Rho guanosine 5'\x{2011}triphosphatase, Rac, and Cdc42. Rac and Cdc42 are known regulators of hematopoietic stem and progenitor cell (HSPC) function, however, a direct role for Paks in HSPCs has yet to be elucidated. Lin - Sca1 + c-kit + (LSK) cells from wild-type mice were transduced with retrovirus expressing Pak inhibitory domain (PID), a well-characterized inhibitor of Pak activation. Defects in marrow homing and in vitro cell migration, assembly of the actin cytoskeleton, proliferation, and survival were associated with engraftment failure of PID-LSK. The PID-LSK demonstrated decreased phosphorylation of extracellular signal-regulated kinase (ERK), whereas constitutive activation of ERK in these cells led to rescue of hematopoietic progenitor cell proliferation in vitro and partial rescue of Pak-deficient HSPC homing and engraftment in vivo. Using conditional knock-out mice, we demonstrate that among group A Paks, Pak2 –/– HSPC show reduced homing to the bone marrow and altered cell shape similar to PID-LSK cells in vitro and are completely defective in HSPC engraftment. These data demonstrate that Pak proteins are key components of multiple engraftment-associated HSPC functions and play a direct role in activation of ERK in HSPCs, and that Pak2 is specifically essential for HSPC engraftment.
    Keywords: Hematopoiesis and Stem Cells
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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