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  • 1
    Electronic Resource
    Electronic Resource
    Enzyme-Linked Immunosorbent Assay for the Human Glial Fibrillary Acidic Protein Using a Mouse Monoclonal Antibody (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 44 (1985), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Two enzyme-linked immunosorbent assays (ELISAs) have been developed for the quantification of soluble human glial fibrillary acidic protein (GFAP). The specificity of the assays for GFAP is ensured by the use of a monoclonal antibody directed against a GFAP-specific antigenic determinant. One ELISA is a four-layer system working in the concentration range 5–600 ng GFAP/ml. The other ELISA is a five-layer system and includes a biotin/avidin binding reaction. The latter assay has a working range of 0.5-60 ng GFAP/ml. The assays may be used for quantification of GFAP in CSFs, amniotic fluids, and extracts or homogenates of normal and pathological brain material. GFAP in serum could not be quantified because of unidentified interference. CSFs from 18 nonneurological subjects were found to contain 2–14 ng GFAP/ml (mean 4.1 ng/ml), whereas amniotic fluids from 50 normal pregnant women contained up to 24 ng GFAP/ml (mean 12.4 ng/ml). GFAP concentrations in CSFs from 32 multiple sclerosis patients were found not to be elevated compared to the control group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1985.tb05449.x
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  • 2
    Electronic Resource
    Electronic Resource
    Immunoglobulin M specific for measles in serum and cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases (1978)
    Springer
    Journal of neurology 217 (1978), S. 191-194 
    Details
    ISSN: 1432-1459
    Keywords: Multiple sclerosis ; Subacute sclerosing panencephalitis ; Immunoglobulin M specific for measles ; Serum ; Cerebrospinal fluid ; Fluorescent antibody method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden die spezifischen IgM für Masern im Serum und im Liquor von Patienten mit multipler Sklerose, subakuter sklerosierender Leukoencephalitis und anderen neurologischen Erkrankungen untersucht. Nur drei Serumresultate gaben ein positives Ergebnis. Trotz der statistischen Irrelevanz dieser Daten betonen die Autoren die Bedeutung einer eventuellen viralen Infektion in der Pathogenese der demyelinisierenden Erkrankungen.
    Notes: Summary Serum and cerebrospinal fluid of patients with multiple sclerosis, subacute sclerosing panencephalitis and other neurological diseases have been tested by the indirect fluorescent antibody method for immunoglobulin M specific for measles. Only sera of three patients were positive. This feature is of little statistical importance. Nevertheless the authors emphasize the role of a possible viral infection in the pathogenesis of multiple sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312960
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    Paper (German National Licenses)
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