Keywords:
Aging -- Molecular aspects.
;
Chromosomes.
;
Cells -- Aging.
;
Aging -- Genetic aspects.
;
Electronic books.
Description / Table of Contents:
This text examines the relationship between DNA damage and repair, cellular senescence, genomic instability and ageing. It includes in-depth discussions of various types of DNA damage, the DNA repair network, and cellular responses to genetic damage to assess their impact on the modulation of ageing processes and age-related disease, including cancer development.
Type of Medium:
Online Resource
Pages:
1 online resource (599 pages)
Edition:
1st ed.
ISBN:
9781135546656
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=1405084
DDC:
612.6/7
Language:
English
Note:
Front Cover -- Foreword -- Preface -- Contents -- Contributors -- Chapter 1. Introduction -- Chapter 2. Overview of Chromosomal Instability and Aging Mechanisms -- Chapter 3. Cellular Senescence -- Chapter 4. Telomeric Shortening and Replicative Aging -- Chapter 5. Telomeric Regulation in Eukaryotic Cells -- Chapter 6. Role of Ku at the Telomere -- Chapter 7. Chromosomal Instability in Normative Aging -- Chapter 8. Chromatin, Aging, and Cellular Senescence -- Chapter 9. Werner Syndrome -- Chapter 10 .Bloom Syndrome: Genetic, Cellular, and Molecular Features as Compared to Werner Syndrome -- Chapter 11. Molecular Biology of Rothmund-Thomson Syndrome -- Chapter 12. Hutchinson-Gilford Progeria Syndrome -- Chapter 13. Ataxia-Telangiectasia -- Chapter 14. Nijmegen Breakage Syndrome -- Chapter 15. Dyskeratosis Congenita -- Chapter 16. Genetic Instability and Fanconi Anemia -- Chapter 17. Xeroderma Pigmentosum -- Chapter 18. Down Syndrome -- Chapter 19. Genomic Instability and Yeast Aging -- Chapter 20. Genetics of Aging in the Nematode Caenorhabditis elegans -- Chapter 21. Aging, Somatic Maintenance, and Genomic Stability in Drosophila melanogaster -- Chapter 22. Telomerase-Deficient Mouse Model -- Chapter 23. Animal Models of Oxidative Stress and Aging -- Chapter 24. Conclusions and Future Directions -- Index -- Back Cover.
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