Publication Date:
2018-04-18
Description:
Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant 〈i〉GOT2〈/i〉 expression, Published online: 17 April 2018; doi:10.1038/s41467-018-03803-x Metabolic rewiring of cancer cells can be driven by both extrinsic and intrinsic factors. Here the authors show that microenvironmental factors induce metabolic rewiring of B-cell lymphoma through activation of STAT3 and NF-ΚB resulting in upregulation of the aminotransferase GOT2 and glutamine addiction.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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