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  • 1
    Electronic Resource
    Electronic Resource
    Image formation in a superresolution phase conjugate scanning microscope (1989)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 55 (1989), S. 1707-1709 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Analytical and experimental results of a new type of optical scanning microscope, which uses a phase conjugate mirror and pinholes to achieve superresolution, are presented. This phase conjugate scanning microscope has a higher Rayleigh resolution limit than conventional, single-pass, and double-pass scanning microscopes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.102196
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ALTERATIONS IN GABA METABOLISM AND MET-ENKEPHALIN CONTENT IN RAT BRAIN FOLLOWING REPEATED ELECTROCONVULSIVE SHOCKS (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of electroconvulsive shock (ECS; 120 V for 1 s through ear-clip electrodes) or sub-convulsive shocks (70 V for 1 s) on rat brain GABA and met-enkephalin concentration and GABA turnover has been examined 24 h after a single treatment (×1) or once daily for 10 days (×10). ECS × 10 increased GABA concentrations in the N. caudatus and N. accumbens and decreased the synthesis rate of GABA by 40% and 50% respectively in these regions. Sub-convulsive shocks (× 10 × 10) or ECS × 1 had no effect. No consistent changes were seen in the substantia nigra. Met-enkephalin concentrations increased by 50% in the N. caudatus after ECS × 10 but were unchanged in the cortex and pons/medulla. No other shock regimen had any effect on the concentration of this peptide. The results are discussed in relation to the enhanced monoamine-induced responses seen only after ECS × 10.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb07831.x
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  • 3
    Electronic Resource
    Electronic Resource
    The effects of antipsychotics on the turnover rate of GABA and acetylcholine in rat brain nuclei (1976)
    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 363-365 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We here show that the action of clozapine, chlorpromazine and haloperidol on the turnover rates of ACh and GABA in the nucleus caudatus, nucleus accumbens, globus pallidus and substantia nigra allows for a qualitative differentiation between the biochemical effects elicited by clozapine and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/264363a0
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  • 4
    Electronic Resource
    Electronic Resource
    Synaptic connections from large muscle afferents to the motoneurons of various leg muscles in man (1984)
    Springer
    Experimental brain research 56 (1984), S. 341-350 
    Details
    ISSN: 1432-1106
    Keywords: Human reflexes ; Spinal cord ; Ia EPSP ; Reciprocal inhibition ; Ib EPSP
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cross-correlations between stimuli delivered to peripheral nerves and the discharges of single, voluntarily activated, motor units can provide information about facilitatory and inhibitory projections to single spinal motoneurons in man. The projection frequency, under the given circumstances, of a facilitatory or inhibitory pathway can be obtained from the proportion of the sampled motor units of a given muscle showing the facilitatory or inhibitory effect. Deductions about the shape and relative amplitude of the underlying post-synaptic potentials can be made from the profile of the changes in firing probability. This technique has been used to explore the projections of low threshold muscle afferents to motoneurons of various leg muscles in man. Homonymous facilitation was demonstrated to all the sampled motor units of soleus (SOL), medial gastrocnemius (MG), tibialis anterior (TA) and vastus medialis (VM) and is presumed to represent the effects of the composite muscle spindle group Ia EPSP. Heteronymous facilitation was demonstrated between certain synergists. The projection frequency was less and the magnitude of the change in firing probability was smaller than for homonymous facilitation. SOL motoneurons, however, were not facilitated from low threshold afferents in the medial gastrocnemius nerve. Reciprocal inhibition was demonstrated between certain antagonists. The majority of the sampled motor units of SOL, however, were facilitated from low threshold afferents in the common peroneal nerve. The threshold for this facilitation was higher than for the homonymous facilitation elicited from this nerve and thus a different class of afferents and/or intercalated interneurons may be involved. There are projections across the knee joint in man. Motor units in vastus medialis (VM) were facilitated from low threshold afferents in the common peroneal nerve. It is likely that these reflex connections, which differ from those in other species, reflect the functional relationships between various lower limb muscles in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236290
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action of diazepam (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 289 (1975), S. 369-378 
    Details
    ISSN: 1432-1912
    Keywords: cGMP ; Isoniazid ; Cerebellum ; GABA ; Picrotoxin ; Diazepam ; Convulsions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Subcutaneous injections of isoniazid or picrotoxin increase the cerebellar content of 3′,5′-cyclic guanosine monophosphate (cGMP) without changing the 3′,5′-cyclic adenosine monophosphate cAMP. This increase was dose dependent and the threshold for the cGMP increase was lower than that for convulsions. In cerebellum the increase of cGMP content elicited by isoniazid but not that caused by picrotoxin was paralleled by a decrease of GABA content. Diazepam doses starting from 1.74 μmol/kg intraperitoneally produced a dose dependent decrease of cerebellar cGMP concentration without changing cAMP or GABA content. Smaller doses of diazepam (0.5 μmol/kg i.p.) failed to decrease the basal cerebellar content of cGMP. However, this dose of diazepam antagonized the increase of cGMP produced by isoniazid but not that produced by picrotoxin. Higher doses of diazepam were necessary to block the increase of cerebellar cGMP elicited by picrotoxin. Low doses of diazepam (0.14 μmol/kg) antagonized the convulsions in 50% of the rats injected with 3.3 mmol/kg of isoniazid. The doses of diazepam required to block picrotoxin, pentylenetetrazol or strychnine convulsions were 7, 25 and 40 times higher than those required to block isoniazid convulsions, respectively. Desmethyldiazepam, chloridiazepoxide, oxazepam were also several times more potent in antagonizing isoniazid than picrotoxin, pentylenetetrazol, or strychnine convulsions. In contrast, barbiturates were equipotent against all the convulsants studied. These experiments suggest that diazepam may act in the CNS either by altering the disposition of endogenous GABA or by mimicking the action of GABA at specific synaptic receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508411
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  • 6
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    Modification of structural disorder by hydrostatic pressure in the superconducting cuprate ${\mathrm{YBa}}_{2}{\mathrm{Cu}}_{3}{\mathrm{O}}_{6.73}$ (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-05-10
    Description: Author(s): H. Huang, H. Jang, M. Fujita, T. Nishizaki, Y. Lin, J. Wang, J. Ying, J. S. Smith, C. Kenney-Benson, G. Shen, W. L. Mao, C.-C. Kao, Y.-J. Liu, and J.-S. Lee Compelling efforts to improve the critical temperature ( T c ) of superconductors have been made through high-pressure application. Understanding the underlying mechanism behind such improvements is critically important; however, much remains unclear. Here we studied ortho-III YBa 2 Cu 3 O 6.73 (YBCO) using... [Phys. Rev. B 97, 174508] Published Wed May 09, 2018
    Keywords: Superfluidity and superconductivity
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 7
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    Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit (2012)
    Oxford University Press
    Details
    Publication Date: 2012-07-22
    Description: The bacterial homologue of C4orf14, YqeH, has been linked to assembly of the small ribosomal subunit. Here, recombinant C4orf14 isolated from human cells, co-purified with the small, 28S subunit of the mitochondrial ribosome and the endogenous protein co-fractionated with the 28S subunit in sucrose gradients. Gene silencing of C4orf14 specifically affected components of the small subunit, leading to decreased protein synthesis in the organelle. The GTPase of C4orf14 was critical to its interaction with the 28S subunit, as was GTP. Therefore, we propose that C4orf14, with bound GTP, binds to components of the 28S subunit facilitating its assembly, and GTP hydrolysis acts as the release mechanism. C4orf14 was also found to be associated with human mitochondrial nucleoids, and C4orf14 gene silencing caused mitochondrial DNA depletion. In vitro C4orf14 is capable of binding to DNA. The association of C4orf14 with mitochondrial translation factors and the mitochondrial nucleoid suggests that the 28S subunit is assembled at the mitochondrial nucleoid, enabling the direct transfer of messenger RNA from the nucleoid to the ribosome in the organelle.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
    Published by Oxford University Press
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