ISSN:
1615-2573
Keywords:
Human leukocyte antigen (HLA)
;
Hypertrophic cardiomyopathy (HCM)
;
Hypertrophic obstructive cardiomyopathy (HOCM)
;
Restriction fragment length polymorphism (RFLP)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A large Japanese family with hypertrophic cardiomyopathy (HCM) was examined (n = 61). Ten of 14 affected family members who showed HCM on the basis of electrocardiography and two-dimensional echocardiography were subjected to human leukocyte antigen (HLA)-A,B,C typing by the lymphocyte cytotoxicity test and D, DR typing by restriction fragment length polymorphism (RFLP). As control, the HLA genotype of 14 non-affected family members was analyzed. HLA typing of the affected subjects with HCM revealed a very close association (67%) of HLA-DR (4w8) among A,B,C,D and DR. However, the LOD scores of HLA-DR4 and -DR w8 were 0.693 (Θ = 0.35) and 0.642 (Θ = 0.30) respectively. These data suggest that HLA-loci, analyzed on the basis of RFLP, may not be related with familial HCM with or without obstruction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01744869
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