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  • 1
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 71 (1997), S. 674-676 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Current–voltage characteristics under illumination of monochromatic light for metal-free tetrabenzporphyrin, metal-free triazatetrabenzporphyrin, and metal-free phthalocyanine in (indium–tin–oxide)/porphyrin/Al sandwich cells seem to show high-energy conversion efficiencies of 14%, 7.7%, and 5.5%, respectively. However, according to the simultaneous measurement of both short-circuit photocurrent and transmittance of the aluminum electrode with time, the transmittance of Al linearly increases as the photocurrent flows into the external circuit. It is concluded that all photocurrents in the above cells arise from photoaccelerated corrosion of aluminum electrode and do not originate from conversion of light energy to electrical energy. © 1997 American Institute of Physics.
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  • 3
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 68 (1996), S. 427-429 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The photovoltaic properties of ITO (indium tin oxide)/C60/H2(pc), (pc=phthalocyanine)/Au sandwich solar cells are investigated. The cell prepared at a higher vacuum (1×10−6 Torr) shows an open-circuit photovoltage (VOC) of 0.18 V, a short-circuit photocurrent (JSC) of 89 μA cm−2, a fill factor (ff) of 0.25, and an energy conversion yield (η) of 0.03% when illuminated by white light with 12.5 mW cm−2 intensity. The photocurrent action spectra of the cell reveal that photocurrent is generated at C60/H2(pc) interface with diffusion of C60 excitons because the excited state of C60 has a relatively long lifetime, while the cell prepared at a lower vacuum (3×10−5 Torr) shows a much smaller photocurrent (JSC=1.4 μA cm−2) because oxygen in C60 acts as carrier traps and increases the resistance of C60. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1540-8159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Our objective was to determint; the adequate pacing rate during exercise in ventricular pacing by measuring exercise capacity, cardiac output, and sinus node activity. Eighteen patients with complete AV block and an implanted pacemaker underwent cardiopulmonary exercise tests under three randomized pacing rates: fixed rate pacing (VVJ) at 60 beats/min and ventricular rate-responsive pacing (VVIR) programmed to attain a heart rate of about 110 beats/min ar 130 beats/min (VVIR 110 and VVIR 130, respectively) at the end of exercise. Compared with VVI and VVIR 130, VVIR 110 was associated with an increased peak oxygen uptake(VVIR 110:20.3 ± 4.5 vs VVI: 16.9 ± 3.1; P 〈 0.01; and VVIR 130: 19.0 ± 4.1 mL/min per kg, respectively; P 〈 0.05) and a higher oxygen uptake at anaerobic threshold (15.3 ± 2.7, 12.7 ± 1.9; P 〈 0.01, and 14.6 ± 2.6 mL/min per kg; P 〈 0.05). The atrial rate during exercise expressed as a percentage of the expected maximal heart rate was lower in VVIR 110 than in VVI or VVIR 130 (VVIR 110: 75.9%± 14.6% vs VVI: 90.6%± 12.8%; P 〈 0.01; VVIR 110 vs VVIR 130: 89.1%± 23.1%; P 〈 0.05). There was no significant difference in cardiac output at peak exercise between VVIR 110 and VVIR 130. We conclude that a pacing rate for submaximal exercise of 110 beats/min may be preferable to that of 130 beats/min in respect to exercise capacity and sympathetic nerve activity.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0827
    Keywords: Menopause ; Bone density ; Exercise ; Anaerobic threshold
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The purpose of this study was to determine the optimal intensity of exercise necessary to prevent the postmenopausal bone loss on the basis of anaerobic threshold (AT). Thirty-three postmenopausal women were randomized to control (group C: n=12) or two exercise groups (group H and group M). All women performed a treadmill exercise test, and the AT was measured by expired gas analysis. The exercise regimen consisted mainly of walking at a speed that kept the exercise heart rate above the AT (group H: n=12) or below the AT (group M: n=9). Exercise was performed for 30 minutes, three times a week for 7 months. The bone mineral density (BMD) of the lumbar vertebrae was measured using dual energy X-ray absorptiometry. The BMD level in group C decreased by 1.7±2.7%, but there was a significant increase of 1.1±2.9% in group H. In group M there was a decrease of 1.0±3.1% which did not differ from group C. In group C, serum osteocalcin and urinary hydroxyproline excretion were significantly increased, but no changes were seen in either of the exercise groups. Urinary calcium significantly decreased in the exercise groups. We conclude that short-term (7 months) exercise with intensity above the AT is safe and effective in preventing postmenopausal bone loss.
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  • 6
    ISSN: 1615-2573
    Keywords: Human leukocyte antigen (HLA) ; Hypertrophic cardiomyopathy (HCM) ; Hypertrophic obstructive cardiomyopathy (HOCM) ; Restriction fragment length polymorphism (RFLP)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A large Japanese family with hypertrophic cardiomyopathy (HCM) was examined (n = 61). Ten of 14 affected family members who showed HCM on the basis of electrocardiography and two-dimensional echocardiography were subjected to human leukocyte antigen (HLA)-A,B,C typing by the lymphocyte cytotoxicity test and D, DR typing by restriction fragment length polymorphism (RFLP). As control, the HLA genotype of 14 non-affected family members was analyzed. HLA typing of the affected subjects with HCM revealed a very close association (67%) of HLA-DR (4w8) among A,B,C,D and DR. However, the LOD scores of HLA-DR4 and -DR w8 were 0.693 (Θ = 0.35) and 0.642 (Θ = 0.30) respectively. These data suggest that HLA-loci, analyzed on the basis of RFLP, may not be related with familial HCM with or without obstruction.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-7241
    Keywords: metoprolol ; captopril ; congestive heart failure ; mice ; encephalomyocarditis virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We assessed the therapeutic efficacy of a low-dose combination of metoprolol and captopril given orally to C3H/Hej mice that developed dilated and hypertrophied hearts after being inoculated with the encephalomyocarditis virus. Mice were randomly assigned to one of six 8-week oral regimens: 1 mg/kg/day of metoprolol (group 1); 10 mg/kg/day of metoprolol (group 2); 1.2 mg/kg/day of captopril (group 3); 12 mg/kg/day of captopril (group 4); 1 mg/kg/day of metoprolol plus 1.2 mg/kg/day of captopril (group 5); or distilled water (control group). Group 4 exhibited a significantly lower survival rate and body weight than the control group (p〈0.01). Survival rates and body weights were similar in groups 1, 2, 3, 5, and the control group. Low-dose metoprolol plus captopril is superior to low-dose metoprolol, high-dose metoprolol, and low-dose captopril with regard to heart weight and the heart weight/body weight ratio. The left and right ventricular cavity dimensions as well as myocardial necrosis, calcification, and fibrosis were less severe in groups 4 and 5 than in the control group. The left ventricular free wall showed significantly more thinning in group 4 than in the control group (p〈0.01). Our results show that the administration of low-doses of metoprolol and captopril given in combination was effective in this animal model of congestive heart failure and was associated with a reduction in biventricular cavity dimensions and myocardial necrosis.
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  • 8
    ISSN: 1573-7241
    Keywords: myocardial infarction ; remodeling ; amiloride ; Na+-H+ exchange blocker ; myocyte hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated the effects of amiloride, a Na+-H+ exchange blocker, on ventricular remodeling in an infarcted rat model. In the amiloride group, the left descending coronary artery was ligated and rats were given amiloride (1 mg/kg/day, n=11) in their drinking water for 4 weeks. In the control group, rats were given water for 4 weeks (n=8) after myocardial infarction. The rats were killed on day 28. Both the ratio of heart weight to body weight and that of left ventricular weight to body weight were significantly less in the amiloride group (p〈0.05). The diameter of a myocardial fiber in the region adjacent to the operated area was significantly reduced in the amiloride group compared with the control group (p〈0.05). Left ventricular cavity dimension was significantly smaller in the amiloride group than that in control group (p〈0.05). Our findings suggest that amiloride prevents ventricular remodeling after myocardial infarction.
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  • 9
    ISSN: 1573-7241
    Keywords: semotiadil ; right ventricular hypertrophy ; medial thickening ; pulmonary hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study was designed to compare the effects of semotiadil, a novel calcium antagonist, with those of diltiazem on the development of right ventricular hypertrophy and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension. Pulmonary hypertension was induced by a single injection of monocrotaline (80 mg/kg). Twenty-four hours later (day 1), oral administration of semotiadil (10, 30, or 100 mg/kg per day) or diltiazem (100 or 300 mg/kg per day) was initiated. The wall thickness of the right ventricle (RV), the RV myocardial fiber diameter, the percent medial pulmonary artery thickness, and the percent area of smooth muscle in pulmonary arteries were determined on day 28. The magnitude of all parameters was significantly less in the group of seven rats that received semotiadil at 100 mg/kg per day than in the group of seven rats treated with diltiazem at 300 mg/kg per day. Semotiadil at 100 mg/kg per day inhibits the development of RV hypertrophy and medial thickening of pulmonary arteries significantly more effectively than diltiazem at 300 mg/kg per day.
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Cardiovascular drugs and therapy 6 (1992), S. 403-407 
    ISSN: 1573-7241
    Keywords: Lobenzarit ; myocarditis ; suppressor/cytotoxic T cell ; encephalomyocarditis virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Lobenzarit (CCA) is a newly developed immunomodulating drug that has been demonstrated to enhance suppressor T-cell number and function. In this study we investigated the effect of CCA on murine myocarditis induced by the encephalomyocarditis (EMC) virus. Mice were first inoculated with the EMC virus. CCA (100 mg/kg) was administered daily for 14 days, starting on the day the mice were inoculated. The concentrations of Lyt2+ (suppressor/cytotoxic T) cells in the peripheral blood and heart were examined by laser flow cytometry and in situ staining. The concentration of Lyt2+ cells increased significantly in the peripheral blood and heart of CCA-treated mice when compared with untreated mice (blood: 23.0±2.6% vs. 18.8±2.8%, p〈0.05; heart: 30.1±4.6% vs. 15.8±4.3%, p〈0.05, respectively). Surprisingly, however, the severity of myocardial inflammation in CCA-treated mice was significantly greater than in untreated mice (area of inflammation: 33.1±10.5% vs. 18.8 ±19.5%, respectively, p〈0.05). Thus, these findings suggest that CCA may aggravate EMC-induced acute myocarditis by enhancing the number of Lyt2+ cells.
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