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  • 1
    Electronic Resource
    Electronic Resource
    Genotype and phenotype of N-acetyltransferase 2 (NAT2) polymorphism in patients with contact allergy (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 38 (1998), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We investigated whether patients with contact allergy differed from non-contact-allergic, non-atopic controls with regard to genotype and phenotype of the polymorphic enzyme N-acetyltransferase 2 (NAT2). 55 contact-allergic patients recruited from the Information Network of Departments of Dermatology (IVDK) were compared to 85 controls from among local health care personnel. NAT2 activity was calculated from HPLC analysis of the ratio of the caffeine metabolites 5-acetylamino-6-formylamino-3-methyluracil (AFMU) and 1-methylxanthine (1MX) in the urine. NAT2 genotype was determined by polymerase chain reaction (PCR). A statistically significantly increased proportion of rapid acetylators was found in contact-allergic patients. This may have 2 possible implications: acetylation may enhance contact sensitization; or NAT2 status may be a genetic marker for contact sensitizability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1998.tb05709.x
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  • 2
    Electronic Resource
    Electronic Resource
    Bolus Application of a Novel Recombinant Plasminogen Activator in Acute Myocardial Infarction Patients: Pharmacokinetics and Effects on the Hemostatic System (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 667 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb51641.x
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  • 3
    Electronic Resource
    Electronic Resource
    CONDENSED TANNINS OF RAPESEED MEAL (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 44 (1979), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The study was undertaken to determine the amount and nature of condensed tannins in rapeseed meal. No condensed tannins were found in rapeseed meats (endosperm plus germ). The hulls, however, yielded 0.1% condensed tannins by 70% aqueous acetone extraction, the bulk of the condensed tannins in the hulls being unextractable by the extractants used. The basic unit of the isolated polymeric flavanols appeared to be leucocyanidin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1979.tb06427.x
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  • 4
    Electronic Resource
    Electronic Resource
    Sustained division of the attentional spotlight (2003)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 424 (2003), S. 309-312 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] By voluntarily directing attention to a specific region of a visual scene, we can improve our perception of stimuli at that location. This ability to focus attention upon specific zones of the visual field has been described metaphorically as a moveable spotlight or zoom lens that facilitates ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature01812
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  • 5
    Electronic Resource
    Electronic Resource
    The interaction of solid surfaces in aqueous systems (1982)
    Springer
    Colloid & polymer science 260 (1982), S. 444-451 
    Details
    ISSN: 1435-1536
    Keywords: Surface forces ; surface hydration ; electrical double layer ; disjoining pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The interaction between two high-grade polished fused silica plates separated by a thin layer of aqueous LiCl, NaCl and KCl solution, respectively, was determined by means of a selfdeveloped method. Concerning the repulsion created by overlap of the electrical double layers excellent agreement with the DLVO theory down to separation of about 5 nm were found. For still smaller separations a relatively strong additional repulsion arises which according to experimental evidence might be assigned to the overlap of hydration layers emanating chiefly from the alkali metal halide ions adsorbed onto the silica surfaces. Our results agree well with those obtained by Israelachvili et al. and Pashley, who used mica sheets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01448150
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  • 6
    Electronic Resource
    Electronic Resource
    Kritische Evaluation von Fructosamin als Kontrollparameter in der Beurteilung der diabetischen Stoffwechseleinstellung (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 379-385 
    Details
    ISSN: 1432-1440
    Keywords: Diabetes ; Fructosamine ; Non-enzymatic protein glycosylation ; Glycated hemoglobin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary For some years the glycosylated plasma proteins, the so-called fructosamines, have been used for the evaluation of metabolic control in diabetic patients. We studied the usefulness of fructosamine as an intermediate parameter in the control of diabetes and we also corrected fructosamine for serum protein. Furthermore, the dependence on daily times and amounts of food intake were examined for fructosamine alone as well as for protein-corrected fructosamine. Both parameters showed a statistically significant correlation with HbA1C (r=0,7;P〈0,001). Changes in the metabolic state of the diabetic patients were reflected more rapidly by both these parameters than by HbA1C. While the correction of fructosamine for serum protein eliminated its postprandial increase in the diabetic patients, circadian variation remained unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711265
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  • 7
    Electronic Resource
    Electronic Resource
    Buchbesprechungen (1991)
    Springer
    Journal of molecular medicine 69 (1991), S. 334-334 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01644771
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  • 8
    Electronic Resource
    Electronic Resource
    Kritische Evaluation von Fructosamin als Kontrollparameter in der Beurteilung der diabetischen Stoffwechseleinstellung (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 1066-1067 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727010
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  • 9
    Electronic Resource
    Electronic Resource
    Adenine and hypoxanthine metabolism in phythohemagglutinin-stimulated and unstimulated human lymphocytes (1980)
    Springer
    Annals of hematology 40 (1980), S. 137-145 
    Details
    ISSN: 1432-0584
    Keywords: Blutlymphozyten ; Adeninstoffwechsel ; Hypoxanthinstoffwechsel ; Phytohaemagglutinin ; Blood lymphocytes ; Adenine metabolism ; Hypoxanthine metabolism ; Phytohemagglutinin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The uptake and subsequent metabolism of adenine and hypoxanthine in phytohemagglutinin-stimulated and unstimulated peripheral human blood lymphocytes, freshly prepared or cultured, were studied. To investigate the initial step of nucleic acid metabolism the incorporation of14C-purines into the acid soluble material was examined. No preferential uptake of adenine or hypoxanthine was observed in freshly prepared and cultured lymphocytes during an incubation of 1 h. However, cultured cells utilized approximately 1/3 of the purines compared to freshly drawn cells. Within the cells 2/3 of adenine and 1/2 of hypoxanthine were metabolized to nucleotides (mainly AMP and ADP). Incubation of lymphocytes with PHA for 1 h produced in the freshly prepared cells an increase of adenine- and hypoxanthine-uptake to 191% and 153%, in 48 h stimulated cells to 158% and 132%. There was, however, no change in the relative rates of the metabolic routes though the intracellular concentrations of nucleotides formed increased with adenine as substrate to 152% and with hypoxanthine to 161% during a 1 h stimulation. In contrast no enhanced formation of acid soluble nucleotide formation could be observed with PHA stimulation during 48 h. The increased rates of purine uptake and metabolism apparent 1 h after addition of mitogen may be due to an altered transport mechanism at the beginning of the transformation as an adaptive response to the increased requirements for the synthetic processes soon to follow. Once the lymphocytes are transformed no demand of purines is necessary and the uptake and metabolism is switched off.
    Notes: Zusammenfassung Die Aufnahme und der Stoffwechsel von Adenin und Hypoxanthin in Phytohaemagglutinin-stimulierten und unstimulierten Blutlymphozyten wurden untersucht. Durch den Einbau von14C-markierten Purinen in die säurelösliche Fraktion sollte der 1. Schritt des Nukleinsäurestoffwechsels gemessen werden. Zwischen frisch präparierten und 48 h kultivierten Lymphozyten konnte keine bevorzugte Aufnahme von Adenin bzw. Hypoxanthin festgestellt werden. Die kultivierten Zellen metabolisierten jedoch im Vergleich zu den frisch gewonnenen Lymphozyten nur etwa 1/3 der Purine. Intrazellulär wurde 2/3 des Adenins und die Hälfte des Hypoxanthins hauptsächlich zu den Nukleotiden AMP und ADP metabolisiert. Eine 1stündige Inkubation mit PHA führte in den frischen Lymphozyten zu einem Anstieg der Adenin-bzw. Hypoxanthinaufnahme auf 191% bzw. 153% verglichen mit den Ausgangswerten. Hingegen stiegen die entsprechenden Werte während einer PHA-Stimulation von 48 h auf 158% bzw. 132% an. Obwohl die intrazelluläre Bildung der Nukleotide aus Adenin bzw. Hypoxanthin nach 1 h PHA-Stimulation auf 152% bzw. 161% anstieg, kam es zu keiner Änderung der relativen Durchflußraten der verschiedenen Stoffwechselwege. Im Gegensatz war nach 48 h Stimulation keine vermehrte Nukleotidbildung nachweisbar. Sowohl die gesteigerte Aufnahme als auch die erhöhte Nukleotidbildung nach 1 h PHA-Stimulation könnte auf geänderte Transporteigenschaften der Lymphozytenmembran hinweisen und die erste Antwort der Zelle auf den mitogenen Reiz darstellen. Dadurch könnte der gesteigerte Bedarf an niedermolekularen Substanzen für die nachfolgenden Biosynthesen gedeckt werden. Nach abgeschlossener Transformation würde kein vermehrter Bedarf bestehen und somit die Aufnahme und Metabolisierung gedrosselt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01013696
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  • 10
    Electronic Resource
    Electronic Resource
    Purine metabolism in human lymphocytes (1979)
    Springer
    Annals of hematology 38 (1979), S. 447-455 
    Details
    ISSN: 1432-0584
    Keywords: Lymphozyten ; Purinstoffwechsel ; Adenin ; Guanin ; Hypoxanthin ; Lymphocytes ; Purine metabolism ; Adenine ; Guanine ; Hypoxanthine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In peripheral human blood lymphocytes the uptake and metabolism of adenine, guanine, and hypoxanthine was investigated. This was achieved by incubation of purified lymphocytes with14C-purine bases, separation of cells from the incubation medium by a rapid filtration technique, and subsequent separation of the acid soluble material by thin-layer chromatography. No preferential uptake for one of the purine bases was observed. In all cases only traces of14C-purine bases not added originally and labeled nucleosides could be demonstrated. Approximately 2/3 of adenine and 1/2 of guanine or hypoxanthine were converted to nucleotides. Separation of formed nucleotides showed that adenine and guanine were metabolized mainly to their corresponding nucleotides; hypoxanthine was converted to a considerable amount to adenine nucleotides and only to a small proportion into its own nucleotides. These results demonstrate the predominance of adenine nucleotide formation in normal human lymphocytes.
    Notes: Zusammenfassung In peripheren menschlichen Lymphozyten wurden die Aufnahme und der Stoffwechsel von Adenin, Guanin und Hypoxanthin untersucht. Die gereinigten Lymphozyten wurden mit14C-markierten Purinbasen inkubiert und anschlie\end vom Inkubationsmedium mittels rascher Filtrationstechnik getrennt. Eine bevorzugte Aufnahme einer der Purinbasen konnte nicht beobachtet werden. Die dünnschichtchromatographische Auftrennung der säurelöslichen Metabolite ergab kaum eine Bildung von Nukleosiden und anderen als den zugesetzten Purinbasen. Adenin wurde zu ca. 2/3, Guanin und Hypoxanthin hingegen zu etwa der Hälfte zu Nukleotiden aufgebaut, wobei Adenin und Guanin hauptsächlich zu ihren eigenen, Hypoxanthin jedoch zu Adeninnukiektiden metabolisiert wurde. Die Ergebnisse weisen auf die bevorzugte Bildung von Adeninnukleotiden in normalen menschlichen Lymphozyten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01013505
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