GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructuctural Characterization of the Extramammary Paget Cell Plasma Membrane: A Freeze – Fracture Study (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 7 (1980), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The plasma membrane ultrastructure of the extramammary Paget cells was characterized by freeze-fracture electron microscopy, which was first employed for the study of Paget cells. The Paget cell plasma membrane revealed a flat fractured plane with much fewer and smaller desmo-some-particle aggregations than those of the keratinocyte. No gap junctions were detected. Many intramembranous particle-free vesicles were seen in the intercellular spaces. Particle-free blebs projecting from the plasma membranes were seen on some cell surfaces. These features greatly differed from those of keratinocytes. On the other hand, an increase of gap junctions was noticed on the keratinocytes around or in the Paget's disease lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1980.tb01210.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    PREVALENCE OF RAYNAUD'S PHENOMENON AND SPECIFIC CLINICAL SIGNS RELATED TO PROGRESSIVE SYSTEMIC SCLEROSIS IN THE GENERAL POPULATION OF JAPAN (1993)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 32 (1993), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background. In order to evaluate the prevalence rates of Raynaud's phenomenon (RP) and specific clinical signs related to progressive systemic sclerosis (PSS) in the general population of Japan, inquiries were made concerning RP in the hands and dermatologic examinations were also conducted. Methods. One thousand and sixty-three subjects (332 men and 731 women) over 30 years of age who underwent inhabitants' health examinations in 1990 were considered for this study. Results. The prevalence of RP was 3.0% in men and 3.4% in women. In 8 men and 17 women with RP who received the blood tests, the positive rates of antinuclear antibody (ANA) were 12.5% and 35.3% in men and women, respectively. The prevalence rates of all five specific clinical signs related to PSS, sclerodactyly, pitting scars of the fingers, brown pigmentation of the body, shortened frenulum of the tongue, and flexion contracture of fingers, were under 2% in men and 3% in women. In women with RP the prevalence rates of sclerodactyly, pitting scars of the fingertips, brown pigmentation of the body, and shortened frenulum of the tongue were 16.0, 4.0, 4.0, and 16.0%, respectively. These values were significantly higher than those of persons without RP. Conclusions. Because some persons with primary RP may become typical cases of PSS within several years, a follow-up study, particulary for women who have positive titers of ANA with RP, should be carried out to find out whether the persons suffer from PSS or not.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1993.tb04020.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    OCCUPATIONAL OR EXTRINSIC STIMULATION FACTORS AND INITIAL SIGNS OF PROGRESSIVE SYSTEMIC SCLEROSIS (1992)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 31 (1992), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Forty-eight patients with progressive systemic sclerosis (PSS) (man-woman ratio, 7:41) were studied, and detailed questionnaires were used to clarify the relationship between occupational stresses and the initial signs of PSS. All of the patients were right-handed. Raynaud sign was seen in 37 of the 48 patients (77.1%) as the predominant initial sign of PSS, and it first was noticed on the right index and middle fingers. Three sets of extrinsic aggravating factors, vibration stress, fine hand work with mental stress, and exposure to cold, were believed to be related closely to the development of the initial signs because the initial signs appeared after long-term exposure to the extrinsic factors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1992.tb03566.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Characteristics of Malignant Melanoma Cells in the Treatment With Fast Neutrons (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Periodontology 2000 2 (1989), S. 0 
    Details
    ISSN: 1600-0757
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The radioresistance of malignant melanoma cells has been explained by the wide shoulder of the dose-cell-survival curve of the cells exposed to photon beams. Fast neutrons, 30 MeV d-Be, were used to treat patients who had malignant melanoma in order to confirm the biological effects of high linear energy transfer (LET) radiation for tumor control.Seventy-two patients suffering from malignant melanoma participated in the clinical trials with fast neutrons between November 1975 and December 1986. Of 72 patients, 45 had melanoma of the skin, 20 had melanoma of the head and neck, and seven had choroidal melanoma.Five-year survival rate of the patients who had previously untreated melanoma of the skin was 61% and for patients who received postoperative irradiation, it was 35.7% whereas no patients who had recurrent tumor survived over 4 years. Of 22 patients who had melanoma of the skin, stage I, local control in four cases was achieved by irradiation alone, whereas local control was achieved in 17 of 18 patients who required salvage surgery after fast-neutron therapy. The results of pathological studies performed with specimens obtained from salvage surgery have shown that melanoma cells growing in intradermal tissue are radio-resistant, compared with cells growing in intraepidermal tissue. This might suggest that melanoma cells acquire radioresistance when the connective tissue is involved.Five-year survival rate of the patients who had locally advanced melanoma of the head and neck, previously untreated, was 15.4%. Radiation therapy with accelerated protons was suitable for patients suffering from choroidal melanoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0749.1989.tb00224.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    DETECTION OF SCLERODERMA WITH CAPILLAROSCOPIC ABNORMALITIES OF NAILFOLDS (1996)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 35 (1996), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background. Systemic scleroderma is a problem in Gifu Prefecture, Japan. Methods. Three hundred and thirty-two men and 731 women over 30 years of age, who attended the residents’health examination in K town of Gifu Prefecture (population 4835 persons over 30 years of age) had a dermatologic examination. Antinuclear antibody was determined in 85 persons (14 men, 71 women; age 30 to 72 years) who had Raynaud's phenomenon or various clinical features related to systemic scleroderma. Of these 85 persons, 19 agreed to a capillaroscopic examination and of these, 16 showed some capillaroscopic abnormalities. Biopsy specimens of three women among these 16 individuals with capillaroscopic abnormalities were examined also histopathologically. Results. All samples taken from the forearm skins showed thick and packed bundles of collagen with hyalinization and thickened small blood vessels in the dermis, similar to histopathologic features of systemic scleroderma, although all these women had only a sausage-like swelling of the fingers and a shortened frenulum of the tongue. These results suggest that the prevalence of systemic scleroderma can be estimated to affect more than 0.38% of the population in this town. Conclusions. Manual skills and vibration exposure may be associated with systemic scleroderma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1996.tb05051.x
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Gastrointestinale Polyposis mit universeller Alopecie, Onychodystrophie und Pigmentation der Haut (1965)
    Springer
    Archives of dermatological research 221 (1965), S. 144-161 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Es wird über einen Fall mit ausgedehnten Magendarmpolypen, universaler Alopecie, Onychodystrophie und Pigmentation der Haut berichtet. Bei diesem merkwürdigen Syndrom handelt es sich um eine durch Proteinverlust bedingte Gastroenteropathie mit dadurch entstandenen ektodermalen Veränderungen. Differentialdiagnostisch unterscheidet sich das Syndrom von den familiären Polyposiskrankheiten (z. B. Peutz-Jeghers-Syndrom, Gardner-Syndrom und Turcot-Syndrom). Aus den dermato-histologischen Untersuchungen werden mögliche, ätiologische Faktoren bzw. Zusammenhänge zwischen der Magendarmpolyposis und den ektodermalen Störungen diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00515049
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Cutaneous signs (Raynaud's phenomenon, sclerodactylia, and efladema of the hands) and hand-arm vibration exposure (1993)
    Springer
    International archives of occupational and environmental health 64 (1993), S. 587-591 
    Details
    ISSN: 1432-1246
    Keywords: Vibration ; Raynaud's phenomenon ; Sclerodactylia ; Edema
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dermatological tests and examinations of the hand(s) were carried out in vibration-exposed and un exposed males. The subjects were 179 chain-saw workers in private forestry companies and 205 local inhabitants who had never used vibrating tools. The prevalences of Raynaud's phenomenon (RP), sclerodactylia, and edema of the hands were estimated in both groups, and associations between these cutaneous signs and vibration exposure were evaluated. The prevalences of RP and edema in the exposed group were 9.5% and 1.7%, respectively, and in the unexposed group, 2.9% and 1.5%, respectively. Sclerodactylia was seen in 31.8% of the chain-saw workers but in only 6.4% of the unexposed individuals. In statistical analyses based on unconditional logistic regression models with adjustment for age, RP was associated with long-term (≥ 20 years) vibration exposure [odds ratio (OR) = 7.06; 95% confidence interval (CI) = 2.51−19.87]. Sclerodactylia was associated with both short- and long-term vibration exposure (OR = 6.54, Cl = 3.30-13.36; OR = 7.05; CI = 3.41-14.60, respectively). There were significant dose-response relationships between RP and duration of exposure and between sclerodactylia and duration of exposure. Results of function tests indicated a longer recovery time and a higher vibration threshold for the workers with RP. The presence of sclerodactylia, however, did not have any significant influence on function test results. It is possible to conclude that not only RP but also sclerodactylia could be induced by vibration exposure. However, most cases of sclerodactylia were not so serious as to involve disturbances of peripheral circulatory and nerve function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517705
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Membrane characterization of cultured human keratinocytes by freeze-fracture electron microscopy (1983)
    Springer
    Cell & tissue research 234 (1983), S. 561-572 
    Details
    ISSN: 1432-0878
    Keywords: Cultured keratinocytes ; Cell junctions ; Freeze-fracture ; Man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Human skin expiants obtained from 2 to 5-year-old patients with harelips were cultured in NCTC 168 medium at 37° C, in a humidified atmosphere of 5% CO2 in air. After a 2-week incubation period, plasma membranes of the newly grown cells were characterized by freeze-fracture electron microscopy. Desmosomal diameter in cultured keratinocytes was much smaller, ranging from 0.08 to 0.19 μm, than that in vivo, where it ranged from 0.3 to 0.7 μm in diameter. On the E-face of the plasma membranes, attached to the bottom of the culture dish, small particle aggregations were observed. These were thought to be half-desmosomes, each consisting of 10 to 30 particles. Small gap junctions were also observed. These ranged in size from 0.05 to 0.1 urn in diameter. Membranous structures were found adhering to the plasma membrane from the intercellular spaces. These membranous structures may be lipid vesicles, since they are similar in freeze-fracture electron-microscopic features to lamellar lipid structures seen in the intercellular spaces of horny cells in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218651
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...