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  • 1
    Electronic Resource
    Electronic Resource
    Kinetics of collagen fold formation in human type I procollagen and the effect of disulfide bonds (1981)
    s.l. : American Chemical Society
    Biochemistry 20 (1981), S. 1857-1865 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00510a022
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  • 2
    Electronic Resource
    Electronic Resource
    Complement-Mediated Enhancement of HIV-1 Infection Reverses the Anti-HIV-1 Activity of Castanospermine (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 616 (1990), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1990.tb17897.x
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  • 3
    Electronic Resource
    Electronic Resource
    Physical and chemical properties of human type III procollagen (1983)
    s.l. : American Chemical Society
    Biochemistry 22 (1983), S. 1289-1297 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00274a046
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  • 4
    Electronic Resource
    Electronic Resource
    Collagen biosynthesis by cultured Chinese hamster lung cells. Cell-free synthesis of procollagen α chains (1978)
    s.l. : American Chemical Society
    Biochemistry 17 (1978), S. 864-868 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00598a018
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  • 5
    Electronic Resource
    Electronic Resource
    mRNA Transcription linked to the Morphological and Plasma Membrane Changes induced by Cyclic AMP in Tumour Cells (1973)
    [s.l.] : Nature Publishing Group
    Nature 246 (1973), S. 455-458 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Studies on a rat sarcoma link plasma membrane alterations to the activity of DNA-directed RNA polymerase ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/246455a0
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  • 6
    Electronic Resource
    Electronic Resource
    Inhibition of cis-diamminedichloroplatinum (II) — induced renal toxicity in the rat (1986)
    Springer
    Cancer chemotherapy and pharmacology 17 (1986), S. 38-42 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The hydroxyl-containing dithiocarbamates, sodium (di(hydroxyethl)-dithiocarbamate (NaY) and sodium N-methyl, N-dithiocarboxy-D-glucamine (NaG), appear to possess definite advantages over sodium diethyldithiocarbamate (DDTC) in reducing the cis-dichlorodiammineplatinum (Cis-Pt)-induced renal damage in rats given Cis-Pt as an IV bolus of 7.5 mg/kg 1 h before the IP administration of the dithiocarbamate. Renal damage, as estimated by blood urea nitrogen (BUN) values and serum creatinine levels, was less at all times up until sacrifice in animals given naY or NaG than in those given DDTC. An even more effective method for suppression of Cis-Pt renal toxicity is to use a combination of procedures. The most efficacious combination involves a 24-h pretreatment with DDTC or NaG plus acetazolamide and normal saline hydration 30 min before administration of Cis-Pt, followed by post-treatment with NaG. With this combination therapy renal function can be almost completely spared. Although DDTC or NaG pretreatment is highly effective when used in conjunction with NaG post-treatment, DDTC or NaG pretreatment alone has no renal sparing effect on renal function or renal platinum accumulation. In experiments in which antidotes were given 1 h after Cis-Pt and the animals were followed up for 75 days, a chronic interstitial nephritis at 75 days, suggesting a persistent cell-mediated immune response to Cis-Pt-induced renal damage, may be the basis for chronically abnormal renal function resulting from Cis-Pt. Treatment with all three dithiocarbamates, NaY, NaG, and DDTC, reduced the intensity of this cellular reaction and also reduced platinum levels in the kidneys. Although NaY and NaG are effective heavy metal chelators and renal function is spared and kidney platinum levels are substantially reduced by the dithiocarbamates, no parallel loss of antineoplastic activity by Cis-Pt on the rat Walker carcinoma was observed. Since the dithiocarbamates have no known human toxicity that would disqualify their clinical use, phase 1 clinical trials are indicated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299863
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  • 7
    Electronic Resource
    Electronic Resource
    Anomalous electrochemical behavior of clostripain: Evidence for disulfide isolation conformers (1973)
    Springer
    Molecular and cellular biochemistry 1 (1973), S. 95-99 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary Purified preparations of clostripain exhibit two distinct components on analytical and preparative acrylamide gel electrophoresis as well as adsorption chromatography on hydroxylapatite. Both components are of identical molecular size and specific activity. By reducing the enzyme for an extended period of time prior to chromatography, the specific activity increases by a factor of four and the enzyme elutes from the hydroxylapatite column as a homogeneous peak. Enzyme labeled at the active site with3H-TLCK exhibits a similar chromatographic behavior to native enzyme on hydroxylapatite. It is inferred that such behavior may be attributed to a two phase disulfide reduction, one involving reduction of a disulfide thereby freeing an active site SH group and a second disulfide reduction resulting in the chromatographic transition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01659942
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  • 8
    Electronic Resource
    Electronic Resource
    Thiono compounds. 4. In vitro mutagenic and antineoplastic activity of TEPA and thio-TEPA (1984)
    Springer
    Cell biology and toxicology 1 (1984), S. 21-30 
    Details
    ISSN: 1573-6822
    Keywords: tris (1-aziridinyl) phosphate oxide ; tris (1-aziridinyl) phosphate sulfide ; base pair mutations ; Ames mutagenic assay (Salmonella assay) ; human breast carcinoma ; human cervical carcinoma ; human vaginal carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Tris (1-aziridinyl) phosphine oxide (TEPA) and tris (1-aziridinyl) phosphine sulfide (thio-TEPA) induced base pair mutations in the Ames mutagenic assay. Thio-TEPA required metabolic activation while TEPA was active without metabolic activation. Growth of a human vaginal carcinoma (A431), a human breast carcinoma (MDAMB-231), and a human cervical carcinoma (HeLa) were inhibited in soft agar in vitro at concentrations which induced mutagenesis in the Ames Assay. A fourth line, JEG choriocarcinoma, was sensitive to the antigrowth properties of both drugs at concentrations below that which induced mutagenesis. These data suggest that as more antineoplastic agents become available, and as mean survival times increase, knowledge of the relative in vitro sensitivity of a patient's neoplasm to a specific antineoplastic drug (i.e., dose required for growth inhibition) as a function of its mutagenic index might be useful for prediction of clinical remission, as well as the risk of secondary neoplasm induction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00125562
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  • 9
    Electronic Resource
    Electronic Resource
    The correlation of plasma membrane microvilli and intracellular cyclic AMP content in a rat epitheloid kidney cell line (1976)
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 5 (1976), S. 309-316 
    Details
    ISSN: 0091-7419
    Keywords: temperature sensitive mutants ; plasma membrane microvilli ; cyclic AMP ; scanning electron microscopy ; cell synchrony ; neoplastic ; epitheloid cells ; Kirsten murine ; cell tissue culture ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Modulation of the intracellular concentration of cyclic AMP has been associated with a regulatory role in cell division, cell morphology, and physical properties of the plasma membrane. Untransformed rat kidney cells in culture exhibit epitheloid morphology, high intracellular cyclic AMP levels, and contact inhibition of growth. Untransformed rat kidney cells transformed with the Kirsten murine sarcoma virus exhibit a low cyclic AMP content, rapid growth rate, and a loss of contact inhibition. Scanning electron microscopy reveals a distinctive difference in the surface structure of the two cell types during G1 of the cell cycle. The surface of the transformed cell is covered with microvilli while its untransformed counterpart is devoid of microvilli. The presence of microvilli can be controlled as a function of temperature by two temperature-sensitive mutants of the Kirsten sarcoma virus (ts6t6 and ts371 cl 5). In the ts6t6 mutant, growth at 32°C results in a low cyclic AMP content and the presence of microvilli, while growth at 39°C results in a high cyclic AMP content and a decrease in microvilli. The oposite effect is seen with the ts371 cl 5 mutant. Correlation of cyclic AMP content with the presence of microvilli suggests that this surface phenomenon is a function of cyclic AMP concentration.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jss.400050305
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