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  • 1
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Keywords: Measles virus. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (204 pages)
    Edition: 1st ed.
    ISBN: 9783642786211
    Series Statement: Current Topics in Microbiology and Immunology Series ; v.191
    Language: English
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 540 (1988), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 165 (1979), S. 203-214 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The relationship between HLA determinants on effector and target cells and cell-mediated cytotoxicity was studied using the release of 51Cr from measles virus-infected PHA-blasts. HLA compatibility between effector and target cells was not required if effector lymphocytes were derived from measles seropositive adults, from a patient with SSPE, and from children after live measles vaccination. Cytotoxicity was always abolished after removal of Fc receptor-bearing lymphoid cells. In these donors, the effect is, therefore, probably due to K cells. In contrast, lymphocytes from children with acute measles preferentially killed those virus-infected target cells with which they shared HLA antigens. Selective lytic activity was still observed after elimination of Fc receptor-bearing lymphoid cells. It is suggested that HLA-dependent killer cells represent specific cytotoxic T lymphocytes. These cells seem to be limited to the acute phase of measles.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 264 (1976), S. 474-477 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Biological and ultrastructural comparisons of SSPE and measles viruses have indicated some differences57. The present communication compares several SSPE isolates with measles virus in terms of genome homology. The genome of measles and SSPE viruses consists of a single-stranded piece of RNA which ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 272 (1978), S. 460-462 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Electrophoresis of mRNAs on 2.5 % polyacrylamide gels in denaturing conditions (97 % formamide, 6 M urea) according to the method of Villareal et �10 a, Attenuated Edmonston measles strain; b, Woodfolk, a wild measles strain; c, strain LEG SSPE; d, strain USC SSPE. Shown above ...
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0533
    Keywords: Panencephalitis ; Isolated Nerve Cells ; Cytophotometry ; RNA and Protein Increase ; Measles Virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 238 aus histologischen Schnitten isolierte Nervenzellen des Trigeminuskernes eines Falles von SSPE wurden cytophotometrisch analysiert und unter identischen Bedingungen mit 236 Zellen eines Kontrollfalles verglichen. Die Messungen wurden an fixierten ungefärbten Zellen bei 260 mμ und 280 mμ sowie nach Färbung mit Methylenblau, Feulgen, Ninhydrin-Schiff und der Millon-Reaktion bei den jeweiligen Absorptionsmaxima durchgeführt. Bei der SSPE fand sich eine Proteinvermehrung um 40%, eine RNS-Zunahme um 34%, eine DNS-Abnahme um 29% gegenüber der Kontrolle. Die Computer-Analyse der Meßdaten von Zellen mit Ninhydrin-Schiff-Färbung zeigt auf Grund des Verteilungsmusters, daß die Proteinvermehrung nicht nur auf das Cytoplasma beschränkt ist, sondern auch Zellkern und Nucleolus erfaßt hat. Die Zunahme von RNS in den erkrankten Zellen stimmt mit der Annahme überein, daß der SSPE eine Masern-Virus-Infektion zugrunde liegt.
    Notes: Summary A cytophotometric analysis was made of 238 nerve cells isolated from histological sections obtained from the trigeminal nucleus of a SSPE brain and they were compared with 236 control cells of the same region. The measurements were carried out in the ultraviolet spectrum on fixed, unstained cells and in the visible light spectrum after staining the sections with methylene blue, and according to the Feulgen, ninhydrin Schiff, and Millon methods. The SSPE cells showed an increase in proteins by 40%, an increase in RNA by 34% and a decrease in DNA 29% in comparison with control cells. Computer analysis of the data following the ninhydrin Schiff staining revealed protein increase not only within the cytoplasm, but also within the nucleus and nucleolus. This demonstration of RNA increase in SSPE nerve cells may perhaps be explained by a possible infection with an RNA virus.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0533
    Keywords: Panencephalitis ; Brain Tissue Culture ; Histochemistry ; Immunofluorescence ; Measles Virus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An zwei Hirngewebekulturen von subakuter sklerosierender Panencephalitis (SSPE) wurden histochemische und immunhistologische Untersuchungen durchgeführt. Die Kulturen zeigen polygonale Zellformen, Spindel- und mehrkernige Riesenzellen, die z. T. Syncytien bilden und intranucleäre und cytoplasmatische Einschlußkörper enthalten. Histochemisch läßt sich in den Einschlußkörpern ein erhöhter Gehalt an Proteinen und Ribonucleoproteinen (RNP) nachweisen. Das Cytoplasma der Riesen- und Spindelzellen enthält vermehrt Protein, RNP und RNS im Vergleich zu Kontrollzellen. Fluorescenzoptisch läßt sich Masernantigen in Riesen-, Spindel- und z. T. in den polygonalen Zellen nachweisen. Die erhobenen Befunde entsprechen den histochemischen und immunhistologischen Zellveränderungen der SSPE.
    Notes: Summary Histochemical and immunohistological studies were carried out with brain cell cultures derived from two patients with subacute sclerosing panencephalitis (SSPE). Morphologically the cultures showed polygonal, probably histiocytic, cell formations and spindle intranuclear inclusion bodies. An increase in intracellular proteins and ribonucleoprotein was demonstrated by histochemical techniques. Fluorescent microscopy revealed an antigen that reacted with measles-specific immunoglobulin in the spindle cells, in the multinucleated giant cells, and in some of the polygonal cells. The findings described resemble the histochemical and immunohistological cell changes in brains of SSPE patients.
    Type of Medium: Electronic Resource
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