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  • 1
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry research 31 (1992), S. 2547-2555 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2014-09-05
    Description: IntroductionHuman epidermal growth factor receptor 2 (HER2) amplification is frequent in ductal carcinoma in situ (DCIS) of the breast and is associated with poorly differentiated tumors and adverse prognosis features. This study aimed to determine the molecular effects of the HER2 inhibitor lapatinib in patients with HER2 positive DCIS. Methods: Patients with HER2 positive DCIS received 1,500 mg daily of lapatinib for four consecutive weeks prior to surgical resection. Magnetic resonance imaging (MRI) was used to determine changes in tumor volume. The molecular effects of lapatinib on HER2 signaling (PI3K/AKT and RAS/MAPK pathways), cell proliferation (Ki67 and p27) and apoptosis (TUNEL) were determined in pre and post-lapatinib treatment samples. Results: A total of 20 patients were included. Lapatinib was well tolerated with only minor and transient side effects. The agent effectively modulated HER2 signaling decreasing significantly pHER2 and pERK1 expression, together with a decrease in tumor size evaluated by MRI. There was no evidence of changes in Ki67. Conclusions: Four weeks of neoadjuvant lapatinib in patients with HER2-positive DCIS resulted in inhibition of HER2 and RAS/MAPK signaling pathway.Trial registration: 2008-004492-21 (Registered June 25th 2008).
    Print ISSN: 1465-5411
    Electronic ISSN: 1465-542X
    Topics: Medicine
    Published by BioMed Central
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  • 4
    Publication Date: 2016-09-14
    Description: The aviation sector is nowadays looking for a biofuel to partially substitute the fossil fuel used for flights, namely jet fuel. Among the proposed processes for the production of the renewable jet fuel, the hydrotreating process has the better performance to the date. At the final stage of the hydrotreating process, a distillation train is required to obtain hydrocarbon fractions useful as fuels. Conventional or thermally coupled distillation sequences can be used in this step, and it can be expected that thermally coupled sequences require less energy to perform the separation. Nevertheless, in the selection of the best sequence for a given separation it is important to analyze its control properties. In this work a controllability analysis is performed for different distillation sequences used to obtain biofuels from a hydrocarbon renewable mixture, in order to detect the best sequence in terms of control properties.
    Print ISSN: 0930-7516
    Electronic ISSN: 1521-4125
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley-Blackwell
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  • 5
    Publication Date: 2021-05-19
    Description: La biodiversidad de los ecosistemas marino-costeros de Cuba sostiene altos niveles de actividad pesquera. Debido en parte a la fuerte presión pesquera, administradores y científicos reconocen signos de sobrepesca para muchos stocks, intensificados por crecientes tasas de turismo y desarrollo costero. Estos factores amenazan la salud de esos ecosistemas y ponen en peligro el futuro económico y los medios de vida de comunidades costeras y la industria pesquera. Se eligieron nueve stocks dada su importancia en la captura total, valor económico, diversas historias de vida y susceptibilidad a la sobrepesca. Se usó un modelo dependiente solo de captura (COM), Catch-MSY, para evaluar su estado actual. Se encontró que todas las poblaciones están agotadas y que ocho experimentan sobrepesca. Luego, se utilizó un modelo bioeconómico para obtener estimaciones futuras de captura, ganancias y biomasa bajo diversas estrategias de manejo para lograr diferentes objetivos de producción y conservación. El modelo se adaptó al contexto cubano con información local, estimaciones específicas de precios y costos, así como estimaciones de mortalidad por pesca atribuida a la pesca ilegal. Las proyecciones a 50 años muestran potencial para aumentar biomasa y ganancias disminuyendo las capturas. Manteniendo la estrategia actual, sin incentivos económicos y con pesca ilegal, se observó que la biomasa, las ganancias y las capturas disminuyen. Para cada especie individualmente se mostraron resultados más diversos, aunque para la mayoría parece posible mejorar la situación actual. Los resultados muestran oportunidades de recuperación y ayudarán a determinar el potencial de pesquerías multiespecíficas aplicando reformas de manejo sostenible.
    Description: Biodiversity of marine-coastal ecosystems of Cuba sustains high levels of fishing activity. Due in part to heavy fishing pressure, managers and scientists recognize signs of overfishing for many stocks, intensified by increasing rates of tourism and coastal development. These factors threaten the health of those ecosystems and jeopardize the economic future and livelihoods of coastal communities and the fishing industry. Nine stocks were chosen because of their importance in total catch, economic value, a variety of life histories and susceptibility to overfishing. A model depending only on total fishing (COM). Catch-MSY was used to evaluate the current stock status. All the stocks were found to be overfished and eight were found to be experiencing overfishing. Then; a bioeconomic model was used to provide future estimates of fishing, profits, and biomass under various fishery management strategies that aimed to achieve different production and conservation goals. The model was tailored to the Cuban context with local information, local and specific estimates of prices and costs, and estimates of fishing mortality attributed to illegal fishing. 50-year projections show potential for increasing biomass and profits with decreasing fishing. By maintaining the current strategy without economic incentives and with illegal fishing it was observed that biomass, profits and fishing decrease. For each species individually the results were more diverse, although for most it seems possible to improve the current situation. The results show recovery opportunities and will help to map out the potential of multi-specific fisheries with the application of sustainable management reforms.
    Description: Published
    Keywords: Compensaciones de manejo ; Modelo bioeconómico ; Reforma pesquera ; Recuperación de pesquería ; Management tradeoffs ; Bioeconomic model ; Fishery reform ; Fishery recovery
    Repository Name: AquaDocs
    Type: Journal Contribution , Refereed
    Format: pp. 52-61
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