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  • 1
    Electronic Resource
    Electronic Resource
    Derivative Polarography of Carbohydrates (1957)
    s.l. : American Chemical Society
    Analytical chemistry 29 (1957), S. 479-481 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac50162a015
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Polarographic Characteristics of Carbohydrates. The Aldose Oximes and Semicarbazones (1962)
    s.l. : American Chemical Society
    Analytical chemistry 34 (1962), S. 145-147 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60181a044
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Resistance of Protein–Lignin Complexes, Lignins and Humic Acids to Microbial Attack (1958)
    [s.l.] : Nature Publishing Group
    Nature 181 (1958), S. 1478-1479 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Several workers* have prepared synthetic protein lignin complexes simulating soil humic acid. While the reports are somewhat conflicting, in general, these complexes were attacked and degraded by the soil mieronora with some difficulty. A number of protein-lignin complexes were prepared from ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1811478a0
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    Paper (German National Licenses)
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  • 4
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    A Computational Model of Bone-Metastatic Prostate Cancer (2014)
    The American Association for Cancer Research (AACR)
    Details
    Publication Date: 2014-05-02
    Description: Bone metastasis will impact most men with advanced prostate cancer. The vicious cycle of bone degradation and formation driven by metastatic prostate cells in bone yields factors that drive cancer growth. Mechanistic insights into this vicious cycle have suggested new therapeutic opportunities, but complex temporal and cellular interactions in the bone microenvironment make drug development challenging. We have integrated biologic and computational approaches to generate a hybrid cellular automata model of normal bone matrix homeostasis and the prostate cancer-bone microenvironment. The model accurately reproduces the basic multicellular unit bone coupling process, such that introduction of a single prostate cancer cell yields a vicious cycle similar in cellular composition and pathophysiology to models of prostate-to-bone metastasis. Notably, the model revealed distinct phases of osteolytic and osteogenic activity, a critical role for mesenchymal stromal cells in osteogenesis, and temporal changes in cellular composition. To evaluate the robustness of the model, we assessed the effect of established bisphosphonate and anti-RANKL therapies on bone metastases. At approximately 100% efficacy, bisphosphonates inhibited cancer progression while, in contrast with clinical observations in humans, anti-RANKL therapy fully eradicated metastases. Reducing anti-RANKL yielded clinically similar results, suggesting that better targeting or dosing could improve patient survival. Our work establishes a computational model that can be tailored for rapid assessment of experimental therapies and delivery of precision medicine to patients with prostate cancer with bone metastases. Cancer Res; 74(9); 2391–401. ©2014 AACR.
    Print ISSN: 0008-5472
    Electronic ISSN: 1538-7445
    Topics: Medicine
    Published by The American Association for Cancer Research (AACR)
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