Description: We conducted initial palaeomagnetic studies on cores from site AND-2A (77°45.488’S, 165°16.605’E, ~383.57 metres water depth). A total of 813 samples were collected that span from the top of the section down to the base at 1138.54 metres below sea floor (mbsf). Samples were collected every one or two metres down the core, with paired (pilot) samples being collected about every ten to twenty metres to allow us to assess the demagnetisation behaviour of the samples using either alternating field (AF) or thermal demagnetisation. With the exception of only a few intervals, AF demagnetisation was observed to resolve a characteristic remanent magnetisation (ChRM) as well or better than thermal demagnetisation. Thermal demagnetisation was particularly ineffective in many intervals owing to thermal alteration that was common above 500°C and was evident in some samples even at low temperatures. Above Lithostratigraphic Unit (LSU) 8 (436.18 mbsf), where lithologies are generally more coarse grained than lower in the section, resolving a ChRM is difficult and recent overprints or a drilling overprint are a concern. Within LSU 8 and below, most samples have a ChRM that can be resolved. The ChRM is most likely an original depositional magnetisation throughout most of this lower section, although orthogonal demagnetisation diagrams contain evidence that normal polarity overprinting affects some intervals. Based on 40Ar/39Ar dates and diatom datums, the magnetozones identified from the base of the hole up to ~266mbsf are consistent with spanning from either Chron C6n (18.748-19.772 Ma) or C6An.1n (20.040-20.213 Ma) up through Chron C5Br (15.160-15.974 Ma). Above this, intervals of constant polarity are isolated within longer stratigraphic intervals of uncertain polarity, making their correlation with the geomagnetic polarity timescale (GPTS) speculative and highly dependent on ages obtained from other dating methods. One exception is a reversed-to-normal polarity transition that occurs at ~31 mbsf and is interpreted to most likely be the Brunhes/Matuyama boundary. The spacing of polarity reversals below 266 mbsf and their correlation with the GPTS indicates that this part of the stratigraphic section was deposited between 15 to 20 Ma at a mean sedimentation rate of about 18 centimetres (cm)/ thousand year (k.y.).

Description: Published

Description: 193-210

Description: 2.2. Laboratorio di paleomagnetismo

Description: N/A or not JCR

Description: reserved

Description: We use all available chronostratigraphic constraints – biostratigraphy, magnetostratigraphy, radioisotopic dates, strontium-isotope stratigraphy, and correlation of compositional and physical properties to well-dated global or regional records – to construct a preliminary age model for ANDRILL SMS Project’s AND-2A drillcore (77°45.488’S, 165°16.605’E, 383.57 m water depth). These diverse chronostratigraphic constraints are consistent with each other and are distributed throughout the 1138.54 m-thick section, resulting in a well-constrained age model. The sedimentary succession comprises a thick early and middle Miocene section below 224.82 mbsf and a condensed middle/late Miocene to Recent section above this. The youngest sediments are Brunhes age (〈0.781 Ma), as confirmed by a radioisotopic age of 0.691±0.049 Ma at 10.23 mbsf and the occurrence of sediments that have normal magnetic polarity down to ~31.1 mbsf, which is interpreted to be the Brunhes/Matuyama reversal (0.781 Ma). The upper section is punctuated by disconformities resulting from both discontinuous deposition and periods of extensive erosion typical of sedimentary environments at the margin of a dynamic ice sheet. Additional breaks in the section may be due to the influence of tectonic processes. The age model incorporates several major hiatuses but their precise depths are still somewhat uncertain, as there are a large number of erosional surfaces identified within the stratigraphic section. One or more hiatuses, which represent a total 7 to 8 million years of time missing from the sedimentary record, occur between about 50 mbsf and the base of Lithostratigraphic Unit (LSU) 3 at 122.86 mbsf. Similarly, between about 145 mbsf and the base of LSU 4 at 224.82 mbsf, one or more hiatuses occur on which another 2 to 3 million years of the sedimentary record is missing. Support for the presence of these hiatuses comes from a diatom assemblage that constrains the age of the core from 44 to 50 mbsf to 2.06-2.84 Ma, two radioisotopic dates (11.4 Ma) and a Sr‑isotope date (11.7 Ma) that indicate the interval from 127 to 145 mbsf was deposited between 11.4 and 11.7 Ma, and three diatom occurrence datums from between 225.38 and 278.55 mbsf that constrain the age of this upper part of Lithostratigraphic Unit (LSU) 5 to 14.29 - 15.89 Ma. Below the boundary between LSU 5 and 6 sedimentation was relatively continuous and rapid and the age model is well-constrained by 9 diatom datums, seven 40Ar-39Ar dates, one Sr-isotope date, and 19 magnetozones. Even so, short hiatuses (less than a few hundred thousand years) undoubtedly occur but are beyond the resolution of current chronostratigraphic age constraints. Diatom first and last occurrence datums provide particularly good age control from the top of LSU 6 down to 771.5 mbsf (in LSU 10), where the First Occurrence (FO) of Thalassiosira praefraga (18.85 Ma) is observed. The diatom datum ages are supported by radioisotopic dates of 17.30±0.31 Ma at 640.14 mbsf (in LSU 9) and 18.15±0.35 and 17.93±0.40 Ma for samples from 709.15 and 709.18 mbsf (in LSU 10), respectively, and 18.71±0.33 Ma for a sample from 831.67 mbsf (in LSU 11). The sediments from 783.69 mbsf to the base of the hole comprise two thick normal polarity magnetozones that bound a thinner reversed polarity magnetozone (958.59 - 985.64 mbsf). This polarity sequence most likely encompasses Chrons C5En, C5Er, and C6n (18.056 - 19.772 Ma or slightly older given uncertainties in this section of the geomagnetic polarity timescale), but could be also be Chrons C6n, C6r, and C6An.1n (18.748 - 20.213 Ma). Either polarity sequence is compatible with the 40Ar–39Ar age of 20.01±0.35 Ma obtained from single-grain analyses of alkali feldspar from a tephra sample from a depth of 1093.02 mbsf, although the younger interpretation allows a better fit with chronostratigraphic data up-core. Given this age model, the mean sedimentation rate is about 18 cm/k.y. from the top of LSU 6 to the base of the hole.

Description: Published

Description: 221-220

Description: 2.2. Laboratorio di paleomagnetismo

Description: N/A or not JCR

Description: reserved

Description: Author(s): Y. P. Singh, D. J. Haney, X. Y. Huang, I. K. Lum, B. D. White, M. Dzero, M. B. Maple, and C. C. Almasan We investigated the onset of the many-body coherence in the f-orbital single crystalline alloys Ce1−xYbxCoIn5 (0≤x≤0.775) through thermodynamic and magnetotransport measurements. Our study shows the evolution of the many-body electronic state as the Kondo lattice of Ce moments is transformed into an... [Phys. Rev. B 89, 115106] Published Wed Mar 05, 2014

Description: Author(s): K. Huang, L. Shu, I. K. Lum, B. D. White, M. Janoschek, D. Yazici, J. J. Hamlin, D. A. Zocco, P.-C. Ho, R. E. Baumbach, and M. B. Maple We report measurements of electrical resistivity, magnetic susceptibility, specific heat, and thermoelectric power on the system Pr1−xCexPt4Ge12. Superconductivity is suppressed with increasing Ce concentration up to x=0.5, above which there is no evidence for superconductivity down to 1.1 K. The So... [Phys. Rev. B 89, 035145] Published Wed Jan 29, 2014

Description: Background HannaH (NCT00950300) was a phase III, randomized, international, open-label study that compared pharmacokinetics (PK), efficacy, and safety of two different trastuzumab formulations [subcutaneous (s.c.) and intravenous (i.v.)] in HER2-positive, operable, locally advanced, or inflammatory breast cancer in the neoadjuvant/adjuvant setting. The co-primary end points, to show noninferiority of s.c. versus i.v. trastuzumab in terms of serum concentration ( C trough ) and pathologic complete response (pCR) were met; safety profiles were comparable at 12 months' median follow-up. Secondary end points included safety and tolerability, PK profile, immunogenicity, and event-free survival (EFS). We now report updated safety and efficacy data after a median follow-up of 20 months. Patients and methods Patients ( N = 596) were treated with eight cycles of neoadjuvant chemotherapy, administered concurrently with 3-weekly s.c. trastuzumab (fixed dose of 600 mg) or the standard weight-based i.v. method. Following surgery, patients continued trastuzumab treatment to complete 1 year of therapy. Updated analyses of PK, efficacy, safety, and immunogenicity data were carried out. Results s.c. trastuzumab was generally well tolerated and the incidence of adverse events (AEs), including grade 3 or 4 AEs, between treatment groups was comparable. A slightly higher incidence of serious AEs (SAEs), mainly due to infections, was reported with s.c. treatment {64 [21.5%; 95% confidence interval (CI) 17.0%–26.7%] versus 42 (14.1%; 95% CI 10.4%–18.6%) in the i.v. group}; however, the differences were small and often based on rare events, with no observable pattern across reported events. An early analysis of EFS showed rates of 95% in both groups 1 year postrandomization. Exploratory analyses did not reveal an association between toxicity and body weight or exposure. Conclusions Overall, the safety profile of s.c. trastuzumab was consistent with the previously published data from HannaH and the known safety profile of i.v. trastuzumab. EFS rates were comparable between the i.v. and s.c. groups. Clinical trial number NCT00950300.