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  • 1
    Electronic Resource
    Electronic Resource
    Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease (2003)
    [s.l.] : Nature Publishing Group
    Nature genetics 34 (2003), S. 70-74 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] WHIM syndrome is an immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1149
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  • 2
    Electronic Resource
    Electronic Resource
    Pelvic neuroblastoma—Implications for a new favorable subgroup: A Children's cancer group experience (1995)
    Springer
    Annals of surgical oncology 2 (1995), S. 516-523 
    Details
    ISSN: 1534-4681
    Keywords: Neuroblastoma ; Pelvic tumors ; Pediatric solid tumors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: The survival in neuroblastoma is influenced by patient age, disease stage, tumor site, and several biologic factors. This study was undertaken to determine if primary pelvic lesions are associated with an unusually favorable outcome. Methods: Nine hundred eighty-six patients registered on Children's Cancer Group studies from 1980 to 1993 were reviewed, and 41 (4.3%) were found to have pelvic tumors. Survival was analyzed, and correlations among age, stage of disease, surgical resectability, histopathology, serum ferritin, and N-myc oncogene amplification were evaluated. Results: Age at diagnosis was comparable between patients with pelvic and nonpelvic tumors. Disease distribution was similar, with stages III and IV comprising 78% (32 of 41) of pelvic lesions compared with 73% (692 of 945) for nonpelvic tumors. There was no outcome difference in favorable stages (I, II, and IV-S), with 3-year progression-free survival rates of 88% and 82% for pelvic and nonpelvic sites, respectively. However, in stages III and IV, the 3-year progression-free survival was 70% for pelvic lesions compared with 47% for nonpelvic tumors (p=0.04). Some favorable biologic factors were more common in children with pelvic lesions. Conclusions: The pelvis is an unusual primary site for neuroblastoma but represents a more favorable prognostic subgroup, which is most evident in advanced-stage disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02307085
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  • 3
    Electronic Resource
    Electronic Resource
    Stimulation of neutrophil oxidative metabolism by indomethacin (1985)
    Springer
    Inflammation research 16 (1985), S. 336-341 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Human neutrophils exposed to indomethacin demonstrate an enhanced capacity for superoxide ion (O 2 − ) generation when stimulated with opsonized zymosan. Enhancement is not seen with indomethacin-treated cells exposed to solube oxidative stimuli. To further investigate this phenomenon, O 2 − generation, chemiluminescence, and phagocytosis were assessed in human neutrophils preincubated with indomethacin. Zymosan-stimulated O 2 − release was increased from 150 to 300% of controls in neutrophils exposed to 400 μg/ml. indomethacin. Enhancement was not reversed by removal of indomethacin from the medium prior to addition of the stimulus and was dose-dependent at drug concentrations of 5 to 400 μ/ml. Neutrophils exposed to methacin alone also generated more O 2 − than control cells, although this increment was not sufficient to account for the degree of enhancement seen when indomethacintreated cells were exposed to zymosan. Neutrophil cehmiluminescence induced by zymosan was also increased by exposure to indomethacin, and at a drug concentration of 400 μg/ml (1.1 mM), enhancement randed from 253 to 333% of controls. As was observed with O 2 − generation, chemiluminescence of neutrophils was increased in the presence of indomethacin alone, although, to a degree far less than was seen when drug-treated cells were stimulated with zymosan. Phagocytosis of radiolabeledS. aureus by neutrophils incubated with indomethacin was increased 13±5% over controls (P〈0.01,n=5), but was unaltered by incubation of cells with the buffer used to solubilize the drug. The modest degree of enhancement of phagocytosis suggests that increased particle uptake is not the sole mechanism of oxidative enhancement. The data are in keeping with the hypothesis that indomethacin has a direct effect on the neutrophil plasma membrane and/or the O 2 − -forming oxidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01982869
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  • 4
    Electronic Resource
    Electronic Resource
    Differential inhibition of neutrophil superoxide generation by nonsteroidal antiinflammatory drugs (1984)
    Springer
    Inflammation 8 (1984), S. 209-222 
    Details
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to further characterize the effects of nonsteroidal antiinflammatory drugs on neutrophil superoxide (O2 −) generation, human neutrophils were incubated in the presence of sulfinpyrazone, phenylbutazone, and indomethacin prior to exposure to a variety of oxidative stimuli. Stimuli used included the chemotactic peptideN-formyl-methionyl-leucyl-phenylalanine (FMLP, 5.0 × 10−7 M), NaF (20 mM), phorbol myristate acetate (PMA, 3.2 × 10−7 M), and opsonized zymosan (250μg/ml). superoxide release induced by FMLP was inhibited by all three drugs with half-maximal inhibition (Ki50) at 2.5, 30, and 120μM for sulfinpyrazone, phenylbutazone, and indomethacin, respectively. This inhibition was not due to drug interference with the assay system since comparable inhibition was not observed in a cell-free O2 −-generating system. The neutrophil's response to NaF was blunted by sulfinpyrazone (K i50=400μM) and phenylbutazone (K i50=65μM), but was unaffected by indomethacin. A similar inhibitory pattern was observed when zymosan was used as the oxidative stimulus. Sulfinpyrazone and phenylbutazone inhibited the response to zymosan (K i50s of 425 and 32μM, respectively), whereas indomethacin augmented it. PMA stimulation evoked O2 − production which was inhibited by phenylbutazone (K i50=350μM) but not by sulfinpyrazone or indomethacin in concentrations up to 1 mM. The results support the hypothesis that the enzyme system responsible for neutrophil O2 − generation can be activated by more than one mechanism. The results also emphasize the need to evaluate pharmacologie modulation of neutrophil responses in light of the stimulus used to evoke the response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00916096
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