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  • 1
    Electronic Resource
    Electronic Resource
    Computer simulation study of the θ-point in three dimensions. I. Self-avoiding walks on a simple cubic lattice (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 92 (1990), S. 5144-5154 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Using the scanning simulation method we study the tricritical behavior at the Flory θ-point of self-avoiding walks (SAWs) with nearest neighbors attractions ε (ε〈0) on a simple cubic lattice (in the following paper we investigate tricritical trails on the same lattice). The tricritical temperature Tt is −ε/kBTt=0.274±0.006 (one standard deviation). The results for the radius of gyration G and the end-to-end distance R are consistent with the theoretical prediction νt=0.5 and with a logarithmic correction to scaling; the ratio G2/R2 =0.1659±0.0001 (calculated without taking into account correction to scaling) is only slightly smaller than the theoretical asymptotic value 1/6=0.1666.... The results for the partition function Z at Tt lead to γt=1.005±0.017 in accord with theory and to μt=5.058±0.014, where μt is the growth parameter; the correction to scaling in Z is found to be relatively small. For the chain length studied the divergence of the specific heat at Tt (αt(approximately-equal-to)0.3) is significantly larger than that predicted by theory, (ln N)3/11 (i.e., αt=0). Also, at Tt our data are affected by strong correction to scaling and are thus not consistent with the theoretical value of the crossover exponent φt=0.5.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.458548
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  • 2
    Electronic Resource
    Electronic Resource
    Computer simulation study of the θ-point in three dimensions. II. Trails on a simple cubic lattice (1990)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 92 (1990), S. 5155-5161 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A self-attracting trail is a walk on a lattice which may intersect itself but two bonds are not allowed to overlap; an interaction energy ε (ε〈0) is associated with each self-intersection. Using the scanning simulation method, we study the tricritical behavior at the collapse transition of self-attracting trails of N≤250 steps on a simple cubic lattice. In the preceding paper (paper I) tricritical self-avoiding walks (SAWs) on the same lattice have been investigated. The tricritical temperature of trails is −ε/kBTt=0.550±0.004 (one standard deviation). The results for the radius of gyration, G, and the end-to-end distance, R, lead to νt=0.515±0.003, which is larger than νt=1/2, the theoretical prediction for SAWs. The ratio G2/R2=0.1676±0.0001 is slightly larger than 1/6=0.1666 ... predicted by theory for SAWs; The results for the partition function at Kt lead to γt=1.040±0.005 (as compared to the theoretical prediction for SAWs γt=1) and to the growth parameter value μt=5.0023±0.0020. The crossover exponent, φt, is approximately 0.5 as expected for SAWs at tricriticality; this value is significantly smaller than that found for SAWs in paper I. The results of G, R, and Z at Kt are found to be inconsistent with logarithmic corrections to scaling. However, we do not think that the above differences between trails and SAWs are sufficient to suggest unequivocally that the two models belong to different universality classes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.458549
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  • 3
    Electronic Resource
    Electronic Resource
    The collapse transition of self-avoiding walks on a square lattice: A computer simulation study (1989)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 91 (1989), S. 2544-2554 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Employing the scanning simulation method, we study the tricritical behavior (at the Flory θ point) of self-avoiding walks with nearest-neighbors attraction energy ε(−||ε||) on a square lattice. We obtain −ε/kBTt=0.658±0.004, where Tt is the tricritical temperature and kB is the Boltzmann constant. The radius of gyration G and the end-to-end distance R lead to νt(G)=0.5795±0.0030 and νt(R) =0.574±0.006, respectively. We also obtain γt=1.11±0.022 and μt =3.213±0.013, where γt is the free energy exponent and μt is the growth parameter. Three estimates are calculated for the crossover exponent φt , based, respectively, on G, R and the specific heat C: φt (G)=0.597±0.008, φt(R)=0.564±0.009, and φt(C)=0.66±0.02. Our values for νt and γt are close to the Duplantier and Saleur exact values for the θ' point, νt =4/7=0.571... and γt=8/7=1.142 ... . However, our values of φt are significantly larger than the exact value φt=3/7=0.42... . This suggests that the θ and θ' points belong to different universality classes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.457014
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  • 4
    Electronic Resource
    Electronic Resource
    Contamination of palm kernel meal with Aspergillus flavus affects its nutritive value in pelleted feed for tilapia, Oreochromis mossambicus (2001)
    Oxford, UK : Blackwell Science Ltd
    Aquaculture research 32 (2001), S. 0 
    Details
    ISSN: 1365-2109
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: An assessment of the nutritive value of palm kernel meal (PKM) and aflatoxin-contaminated PKM (obtained by fermenting PKM with Aspergillus flavus) as a dietary ingredient in pelleted feed for tilapia, Oreochromis mossambicus Peters, was carried out in a 12-week feeding trial. Seven isonitrogenous (40% crude protein) and isoenergetic (15.1 kJ g−1) practical diets were formulated and fed close to apparent satiation to triplicate groups of 12 fish (mean initial weight 8.4 ± 0.1 g). The control diet contained 30% fish meal and 10% soybean meal (SBM) proteins. Four other experimental diets containing 20% and 50% of the SBM protein replaced by either PKM or fermented PKM, respectively, were formulated. Two additional diets containing either PKM or fermented PKM supplemented with a commercial aflatoxin adsorber (0.5% SorbatoxTM) were also formulated. Measured aflatoxin B1 levels in the fermented PKM-based diets ranged from 75 to 100 µg kg−1 diet. The growth performance and feed utilization efficiency of tilapia fed fermented PKM-based diets were significantly lower than in fish fed the control diet at all inclusion levels (P 〈 0.05). Despite a small reduction, weight gains of tilapia fed PKM-based diets were not significantly different compared with fish fed the control diet. The addition of 0.5% Sorbatox did not produce any beneficial or negative effects to the growth of tilapia. Under the dietary conditions of the present experiment, it was concluded that PKM can substitute up to 50% SBM in practical diets for O. mossambicus without much adverse effect to fish growth. However, when PKM was contaminated with A. flavus, its' incorporation into tilapia diets resulted in growth depression as a result of decreased diet digestibility and also possibly because of the presence of anti-nutrients found in the contaminated PKM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2109.2001.00625.x
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  • 5
    Electronic Resource
    Electronic Resource
    Strong-coupling calculation of the mass ratio in supersymmetric field theory
    Amsterdam : Elsevier
    Physics Letters B 154 (1985), S. 381-385 
    Details
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0370-2693(85)90413-7
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  • 6
    Electronic Resource
    Electronic Resource
    A new scheme for strong-coupling calculations in supersymmetric field theory
    Amsterdam : Elsevier
    Physics Letters B 166 (1986), S. 78-82 
    Details
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0370-2693(86)91159-7
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  • 7
    Electronic Resource
    Electronic Resource
    Strong-coupling approximation in supersymmetric field theory
    Amsterdam : Elsevier
    Physics Letters B 134 (1984), S. 225-229 
    Details
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0370-2693(84)90676-2
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  • 8
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    A pilot, quasi-experimental, mixed methods investigation into the efficacy of a group psychotherapy intervention for caregivers of outpatients with cancer: the COPE study protocol (2015)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2015-11-21
    Description: Introduction Despite the rising trend of cancer prevalence and increase in family caregiving, little attention has been paid to the efficacy of psychosocial interventions among Asian caregiver samples, particularly support groups, given the benefits that have been shown in studies on Western populations. This trial aims to evaluate the effectiveness of a pilot 4-week group psychotherapy for Singaporean family caregivers of patients receiving outpatient care. Methods and analysis Facilitated by a clinical psychologist, this intervention is primarily based on the brief integrative psychological therapy with a supportive-expressive intent. Participants will be recruited while they are accompanying their care recipients for outpatient consultations. Since this is a pilot study, a sample size of 120 participants is targeted on the basis of sample sizes of previous studies. The study adopts a quasi-experimental design, as participants are assigned the intervention or control arms based on their availability to attend the intervention. A mixed methods approach is used to evaluate the outcomes of the intervention. A self-administered battery of tests is completed at four time points: baseline, postintervention and follow-up at 1-month and 2-month postinterventions; semi-structured interviews are conducted at baseline and post-intervention. Primary outcomes are quality of life and anxious and depressive symptoms; secondary outcomes are stress and basic psychological needs. Analysis using analysis of covariance would be conducted to determine the effectiveness of the intervention. Ethics and dissemination This study protocol has ethics approval from the National Healthcare Group Domain Specific Review Board (NHG DSRB Ref: 2013/00662). Written informed consent is obtained from every participant. Results will be disseminated through journals and conferences, and will be particularly relevant for clinicians intending to implement similar support groups to address the psychosocial concerns of caregivers, as well as for researchers seeking to refine the structure and evaluate the effectiveness of such programmes. Trial registration number Current Controlled Trials NCT02120183 ( https://clinicaltrials.gov/show/NCT02120183 )
    Keywords: Open access, Evidence based practice, Mental health, Oncology, Research methods
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 9
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    Biopsychosocial correlates of hope in Asian patients with cancer: a systematic review (2016)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2016-10-08
    Description: Objective To examine the factors associated with hope and hopelessness in patients with cancer in Asian countries, and the instruments used to measure hope and hopelessness. Methords A comprehensive systematic review was conducted with search terms, including cancer, hope, hopelessness and individual Asian country names, on CINAHL, Embase, PsycINFO, PubMed and Scopus databases. Only quantitative studies on adult cancer populations in Asia examining hope or hopelessness were included. Results A total of 2062 unique articles were retrieved from the databases, and 32 studies were selected for inclusion in this review. Hope and hopelessness were most frequently measured with the Herth Hope Index and the Mental Adjustment to Cancer Scale, respectively. The biopsychosocial factors that were most consistently associated with hope and hopelessness included sociodemographic variables (education, employment and economic status); clinical factors (cancer stage, physical condition and symptoms); and psychosocial factors (emotional distress, social support and connections, quality of life, control or self-efficacy, as well as adjustment and resilience). Discussion There is a need for more studies from South and Southeast Asia as most studies hailed from East Asia. This review highlighted the possibility of cultural differences influencing factors related to hope, suggesting that cross-cultural studies specifically would facilitate understanding behind these variations, although future reviews on hope should also include studies on hopelessness for a comprehensive understanding of the concept. Finally, more longitudinal research could be conducted to assess whether the factors associated with hope and hopelessness change over time and disease progression.
    Keywords: Open access, Mental health, Oncology
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 10
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    NMR Study of the Dengue Protease [Microbiology] (2013)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2013-05-04
    Description: The dengue virus (DENV) is a mosquito-borne pathogen responsible for an estimated 100 million human infections annually. The viral genome encodes a two-component trypsin-like protease that contains the cofactor region from the nonstructural protein NS2B and the protease domain from NS3 (NS3pro). The NS2B-NS3pro complex plays a crucial role in viral maturation and has been identified as a potential drug target. Using a DENV protease construct containing NS2B covalently linked to NS3pro via a Gly4-Ser-Gly4 linker (“linked protease”), previous x-ray crystal structures show that the C-terminal fragment of NS2B is remote from NS3pro and exists in an open state in the absence of an inhibitor; however, in the presence of an inhibitor, NS2B complexes with NS3pro to form a closed state. This linked enzyme produced NMR spectra with severe signal overlap and line broadening. To obtain a protease construct with a resolved NMR spectrum, we expressed and purified an unlinked protease complex containing a 50-residue segment of the NS2B cofactor region and NS3pro without the glycine linker using a coexpression system. This unlinked protease complex was catalytically active at neutral pH in the absence of glycerol and produced dispersed cross-peaks in a 1H-15N heteronuclear single quantum correlation spectrum that enabled us to conduct backbone assignments using conventional techniques. In addition, titration with an active-site peptide aldehyde inhibitor and paramagnetic relaxation enhancement studies demonstrated that the unlinked DENV protease exists predominantly in a closed conformation in solution. This protease complex can serve as a useful tool for drug discovery against DENV.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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