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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    World journal of surgery 11 (1987), S. 783-789 
    ISSN: 1432-2323
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Du mois d'août 1982 au mois d'août 1985, deux cents cinquante malades ont subi une intervention assurant l'écoulement normal des urines grâce à la constitution d'une néo-vessie iléale. Chez 171 malades, elle a été réalisée pour traiter des cancers vésicaux étendus. Chez 19 patients une cystectomie et une poche de Kock furent pratiquées pour traiter des troubles vésicaux neurologiques. Dans 60 cas une forme inadéquate de conduit urinaire conduisit à la constitution d'un réservoir iléal. Il en fut de même après 10 urétéro-sigmoitostomies et chez 2 malades dont l'un était porteur d'une urétéroplastie cutanée et l'autre d'un drain sus pubien. Des complications précoces se manifestèrent chez 42 opérés (16%) et furent à l'origine de 5 (2%) décès post-opératoires. Le taux de complications fut de 18% chez les 190 patients qui furent traités par cystectomie et construction d'une poche de Kock et de 12% chez les 60 sujets soumis à une intervention de conversion. Des complications tardives se sont manifestées chez 77 (31%) des 245 opérés qui survécurent. La plupart consistèrent en une fuite, une hernie au niveau de la stomie, une difficulté du cathétérisme. Au cours de cette expérience des modifications successives de la technique furent adoptées et les auteurs ont le sentiment que le taux des complications tardives s'abaissera et que les résultats s'amélioreront. Ces modifications sont étudiées en détail dans l'article.
    Abstract: Resumen Doscientos cincuenta pacientes fueron sometidos a desviación urinaria por medio de un reservorio ileal continente entre agosto de 1982 y agosto de 1985; ciento setenta y uno procedimientos estuvieron asociados con cistectomía radical por cáncer invasivo de la vejiga; 19 pacientes recibieron cistectomía y desviación con bolsa de Kock para resolver complicaciones de vejiga neurogénica, y 60 fueron convertidos a un reservorio ileal continente a partir de una forma insatisfactoria de desviación urinaria, 10 con ureterosigmoidostomía y 2 con un tubo suprapúbico o una ureterostomía cutánea. Complicaciones tempranas se presentaron en 42 pacientes (16%), las cuales resultaron en 5 (2%) muertes postoperatorias. La tasa de complicaciones fue de 18% en los 190 pacientes sometidos a cistectomía radical con construcción de bolsa de Kock y de 13% en 60 sometidos a procedimientos de conversión. Complicaciones tardías ocurrieron en 77 (31%) de 245 pacientes que sobrevivieron la operación. La mayoría de las complicaciones tardías se debió a escape de orina, hernia paraestomal y/o dificultad con la cateterización. En el curso de esta experiencia se han desarrollado en forma continua modificaciones técnicas que, creemos, habrán de disminuir la tasa de complicaciones tardías y mejorar los resultados finales. Tales modificaciones son discutidas en detalle.
    Notes: Abstract From August, 1982, to August, 1985, a total of 250 patients have undergone diversion by means of a continent ileal reservoir. One hundred seventyone were in conjunction with radical cystectomy for the management of invasive bladder cancer; 19 underwent cystectomy and Kock pouch diversion to resolve complications of neurogenic bladder; and 60 patients were converted to a continent ileal reservoir from an unsatisfactory form of conduit, 10 from ureterosigmoidostomy and 2 patients from either a suprapubic tube or cutaneous ureterostomy. Early complications occurred in 42 patients (16%) resulting in 5 (2%) postoperative deaths. The complication rate was 18% among the 190 undergoing cystectomy with Kock pouch construction and 13% among the 60 undergoing conversion. Late complications have occurred in 77 (31%) of the 245 patients surviving the operation. Most late complications are due to leakage, parastomal hernia, and/or difficulty with catheterization. During this experience continuing modifications have developed that we feel will reduce the late complication incidence and improve results. These modifications will be discussed in detail.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    World journal of urology 3 (1985), S. 155-158 
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The continent ileal reservoir, as introduced by Dr. Nils Kock, presents an intriguing but challenging option in the field of urinary diversion. From August 1982 through December 1984, 157 patients underwent this type of surgery at our institution. Of these patients, 103 underwent simultaneous radical cystectomy for cancer, 42 had a previous urinary diversion of another type, and 12 had neurogenic bladders. Our experience represents a series of expected complications and ongoing modifications to the surgical technique. A total of 24 patients experienced early complications requiring 6 reoperations, and 32 patients were noted to have 41 late complications necessitating 33 further revisional surgeries. There were 3 operative mortalities and 12 late deaths due to nonoperative causes. Three patients required conversion of their Kock pouch to an ileal conduit. The end result leaves 139 patients for chronic follow-up, of whom 134 are doing extremely well and fit all of the criteria for a successful continent diversion. They catheterize every 5–6 h with a mean reservoir capacity of 800–1000 cc and wear only a small pad over their stoma. The long-term results continue to be encouraging and suggest that the continent ileal reservoir is a definite alternative for the patient who requires a cutaneous urinary diversion and who is seeking an improved quality of life.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    World journal of urology 2 (1984), S. 53-56 
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Expectant therapy is based on the accuracy of noninvasive staging methods, a belief that the complications of surgery (such as ejaculatory dysfunction) are unacceptable, and the efficacy of combination chemotherapy. The authors dispute the accuracy of noninvasive staging, review the recent data suggesting that infertility is a less common complication of surgery than has been supposed, and highlight the short-term and long-term toxic effects of chemotherapy in support of their conviction that surgical treatment is preferable to expectant therapy for clinically low-stage nonseminomatous testicular cancer.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-0646
    Keywords: cyclophosphamide ; interleukin-2 ; kidney neoplasms ; phase II
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Abstract Thirteen patients with metastatic renal cancer were treated in a phase II trial with interleukin-2, 21.6 million IU/m2 intravenously daily for five days on two consecutive weeks, starting 3 days after the administration of low dose cyclophosphamide 350 mg/m2 intravenously. Treatment cycles were repeated every 21 days. No responses were seen (95% Confidence Interval: 0–22%). The most common toxicities were fever, fatigue, hypotension, nausea/emesis, and myalgia/arthralgia. There were 11 episodes of Grade III toxicity including Grade III hypotension in 7 patients. Because of the significant toxicity and the lack of observed response, the study was discontinued. Cyclophosphamide and interleukin-2 at the dose and schedule used in this study has considerable toxicity and is unlikely to improve on response rates previously seen with other IL-2-based regimens in metastatic renal cancer.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1615-5947
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report describes the surgical management of 24 patients with concurrent abdominal aortic aneurysm (AAA) and urinary tract neoplasm. The patient population consisted of 22 men and two women whose average age was 65.5 years. AAA sizes ranged from 3.1 to 9.0 cm (mean 5.2 cm) in diameter. Urinary tract neoplasms included transitional cell carcinoma (TCC) of the bladder (n = 19), adenocarcinoma of the prostate (n = 3), and TCC of the renal pelvis (n = 2). Urologic procedures included radical prostatectomy, radical nephroureterectomy, and radical cystoprostatectomy with continent or ileal loop urinary diversion. The AAA was resected at the time of the Urologic procedure in 12 patients (group I) or prior to the Urologic procedure in five patients (group II) and was left in situ in seven patients (group III: AAA diameter 3.1 to 5.5 cm). All patients but one in group I recovered without complications. One patient developed an infection postoperatively as a result of fluid collection anterior to the aortic vascular graft; the fluid was successfully drained and the patient subsequently recovered uneventfully. All patients in group II had a marked retroperitoneal desmoplastic reaction at the time of the Urologic procedure as a result of prior aneurysmectomy, which complicated the ureteral dissection. One patient later required an ileal ureteral reconstruction for obliterative fibrosis of the ureter. At a mean follow-up of 34 months, no infectious or mechanical complications of the vascular prosthesis occurred in group I or II. Eight patients in group I and two in group II are alive. Three have died of metastatic disease and two of myocardial infarction. Of the seven patients in group III, four subsequently required AAA resection for an increase in AAA size and three have died. One patient died of a ruptured AAA, whereas the other two died of metastatic disease and unknown causes, respectively. This surgical experience suggests that simultaneous correction of a concomitant AAA and Urologic neoplasm is feasible and advisable. It is technically superior, minimizes perioperative complications and later graft sepsis, avoids the need for later AAA resection, and eliminates the risk of AAA rupture.
    Type of Medium: Electronic Resource
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