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  • 1
    Electronic Resource
    Electronic Resource
    A size of ∼1  au for the radio source Sgr A* at the centre of the Milky Way (2005)
    [s.l.] : Nature Publishing Group
    Nature 438 (2005), S. 62-64 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Although it is widely accepted that most galaxies have supermassive black holes at their centres, concrete proof has proved elusive. Sagittarius A* (Sgr A*), an extremely compact radio source at the centre of our Galaxy, is the best candidate for proof, because it is the closest. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nature04205
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A THREE-DIMENSIONAL FINITE-VOLUME/NEWTON METHOD FOR THERMAL-CAPILLARY PROBLEMS (1997)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 40 (1997), S. 621-636 
    Details
    ISSN: 0029-5981
    Keywords: three-dimensional ; finite volume method ; Newton's method ; free boundaries ; thermal-capillary ; floating zone ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: A three-dimensional finite-volume/Newton method is developed for solving thermal-capillary problems in materials processing. The conductive heat transfer, melt-solid interfaces, the melt-gas free surface, and the shape of grown material are calculated simultaneously. The implementation of interface and free surface boundary conditions, as well as co-ordinate transformation, is described in detail. During the Newton iterations, due to the complexity of the problem, the Jacobian matrix is estimated by finite differences, and the linear equations are solved by the ILU(0) preconditioned GMRES iterative method. Nearly quadratic convergence of the scheme is achieved. Sample calculations for floating-zone and Stepanov crystal growth are illustrated. © 1997 by John Wiley & Sons, Ltd.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
  • 3
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    OH response to solar cycle [Earth, Atmospheric, and Planetary Sciences] (2013)
    National Academy of Sciences
    Details
    Publication Date: 2013-02-06
    Description: The hydroxyl radical (OH) plays an important role in middle atmospheric photochemistry, particularly in ozone (O3) chemistry. Because it is mainly produced through photolysis and has a short chemical lifetime, OH is expected to show rapid responses to solar forcing [e.g., the 11-y solar cycle (SC)], resulting in variabilities in...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    A Novel Splice Variant of Cav1.2 Channel in Neonatal Heart [Molecular Biophysics] (2015)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2015-04-04
    Description: L-type Cav1.2 Ca2+ channel undergoes extensive alternative splicing, generating functionally different channels. Alternatively spliced Cav1.2 Ca2+ channels have been found to be expressed in a tissue-specific manner or under pathological conditions. To provide a more comprehensive understanding of alternative splicing in Cav1.2 channel, we systematically investigated the splicing patterns in the neonatal and adult rat hearts. The neonatal heart expresses a novel 104-bp exon 33L at the IVS3-4 linker that is generated by the use of an alternative acceptor site. Inclusion of exon 33L causes frameshift and C-terminal truncation. Whole-cell electrophysiological recordings of Cav1.233L channels expressed in HEK 293 cells did not detect any current. However, when co-expressed with wild type Cav1.2 channels, Cav1.233L channels reduced the current density and altered the electrophysiological properties of the wild type Cav1.2 channels. Interestingly, the truncated 3.5-domain Cav1.233L channels also yielded a dominant negative effect on Cav1.3 channels, but not on Cav3.2 channels, suggesting that Cavβ subunits is required for Cav1.233L regulation. A biochemical study provided evidence that Cav1.233L channels enhanced protein degradation of wild type channels via the ubiquitin-proteasome system. Although the physiological significance of the Cav1.233L channels in neonatal heart is still unknown, our report demonstrates the ability of this novel truncated channel to modulate the activity of the functional Cav1.2 channels. Moreover, the human Cav1.2 channel also contains exon 33L that is developmentally regulated in heart. Unexpectedly, human exon 33L has a one-nucleotide insertion that allowed in-frame translation of a full Cav1.2 channel. An electrophysiological study showed that human Cav1.233L channel is a functional channel but conducts Ca2+ ions at a much lower level.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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