Publication Date:
2011-08-25
Description:
We study the cytotoxicity of indium chloride (InCl 3 ) in Chinese hamster lung fibroblasts, the V79 cells, using MTT assay. The results showed that InCl 3 did not induce significant cytotoxicity at various concentrations tested. In addition, the frequency of micronuclei (MN) was assayed to evaluate the genotoxic effects of InCl 3 in V79 cells. InCl 3 at concentrations ranged 0.1–1 μM significantly increased MN frequency in a concentration-dependent manner. Both catalase and superoxide dismutase at concentrations of 75 and 150 μg/mL significantly inhibited InCl 3 -induced MN. Similarly, Germanium oxide (GeO 2 ) and dimercaprol expressed antigenotoxic effects. From these findings, it is concluded that InCl 3 is a potent genotoxic chemical, which may be mediated partly by inducing oxidative stress. The significance of this study shows that the workers in the semiconductor factories should be cautious in exposing to the hazardous genotoxic InCl 3. © 2011 Wiley Periodicals, Inc. Environ Toxicol, 2011.
Print ISSN:
1520-4081
Electronic ISSN:
1522-7278
Topics:
Energy, Environment Protection, Nuclear Power Engineering
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