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  • 1
    Electronic Resource
    Electronic Resource
    VAGINAL ADENOSIS: CLINICAL AND PATHOLOGICAL FEATURES WITH SPECIAL REFERENCE TO MALIGNANT CHANGE (1971)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 78 (1971), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Six cases of vaginal adenosis have been described. In two of them adenocarcinoma of the vagina was present; in one of these clear transition from benign adenosis to carcinoma was evident whilst in the other the association of benign mucous glands with the carcinoma strongly suggests that the latter arose from the former. The first of these patients survived for nine years free from disease and the second died of metastases after 7 years. In a third patient it was thought that early malignant change might be present. Despite the absence of treatment, however, no obvious change has occurred in the lesion over three years and smears have remained negative. The most prominent presenting symptom in the remaining cases was a mucoid vaginal discharge; other important symptoms include dyspareunia and postcoital bleeding. Treatment is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1971.tb00234.x
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  • 2
    Electronic Resource
    Electronic Resource
    Outcome of pregnancy following induced abortion Report from the joint study of the Royal College of General Practitioners and the Royal College of Obstetricians and Gynaecologists (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. A total of 1590 general practitioners and 795 gynaecologists in England. Scotland and Wales are participating in a long-term, prospective study concerning the sequelae of induced abortion. In the present report a comparison is made between the outcome of the first post-index pregnancy in 745 women whose index pregnancy ended in an induced abortion (cases) and that in 1339 women who had an unplanned index pregnancy but were not referred f o r induced abortion (controls). There were no statistically significant differences between cases and controls. The increased relative risk which was found amongst the induced abortion group of non-viable outcome, low birthweight and shortened gestation, could have arisen by chance. Further analysis of a larger number of pregnancies is required to permit confident interpretation of these observations. The present data provide no reason for alterations in the current management of induced abortion, or the subsequent pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb01102.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    COLLOID (MUCUS SECRETING) CARCINOMA OF THE CERVIX (1971)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 78 (1971), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: From 1944 to 1965, 1,274 primary carcinomas of the cervix were treated at the Chelsea Hospital for Women (Blaikley et al., 1969). Eighty-four (6.1 per cent) were adenocarcinomas. There were only three growths in which mucus secretion was so abundant as to merit the description colloid. Apart from providing evidence of their endocervical origin these tumours present special difficulties in diagnosis and treatment. Vaginal bleeding is a late symptom and due to the delay in diagnosis prognosis is poor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1971.tb00236.x
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  • 4
    Electronic Resource
    Electronic Resource
    Mutations in the genome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype (2000)
    Springer
    Archives of virology 145 (2000), S. 1149-1161 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary.  Although live-attenuated vaccines have been used for some time to control clinical symptoms of the porcine reproductive and respiratory syndrome (PRRS), the molecular bases for the attenuated phenotype remain unclear. We had previously determined the genomic sequence of the pathogenic PRRSV 16244B. Limited comparisons of the structural protein coding sequence of an attenuated vaccine strain have shown 98% homology to the pathogenic 16244B. Here we have confirmed the attenuated phenotype and determined the genomic sequence of that attenuated PRRSV vaccine and compared it to its parental VR-2332 and the 16244B strains. The attenuated vaccine sequence was colinear with that of the strain 16244B sequence containing no gaps and 212 substitutions over 15,374 determined nucleotide sequence. We identified nine amino acid changes distributed in Nsp1β, Nsp2, Nsp10, ORF2, ORF3, ORF5 and ORF6. These changes may provide the molecular bases for the observed attenuated phenotype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007050070115
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  • 5
    Electronic Resource
    Electronic Resource
    Detection of BVD viruses using synthetic oligonucleotides (1991)
    Springer
    Archives of virology 117 (1991), S. 269-278 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This study examined synthetic oligonucleotide probes as potential diagnostic tools for bovine viral diarrhea virus (BVDV). Six 20-base sequences from across the genome were selected by homology analysis of the published genomic sequences of the NADL and Osloss isolates of BVDV. RNA was extracted from 22 BVDV isolates propagated in bovine turbinate (BT) cells, blotted, and probed with32P end-labeled oligonucleotides. The stringency conditions used were such that more than a single base mismatch would result in no hybridization. The probe originating nearest the 5′ end of the viral RNA, ND001, detected 86% of the viral isolates while the other probes detected from 19% to 57%. Both cytopathic and noncytopathic isolates were detected by these synthetic probes. A cocktail of these probes were used to specifically detect BVDV RNA extracted directly from tissues of cattle either persistently or acutely infected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310770
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  • 6
    Electronic Resource
    Electronic Resource
    An astrovirus frameshift signal induces ribosomal frameshifting in vitro (1995)
    Springer
    Archives of virology 140 (1995), S. 1127-1135 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Expression of the astrovirus RNA-dependent RNA polymerase has been hypothesized to be regulated by (− 1) ribosomal frameshifting. Sequence analysis of the 70 nucleotide region between open reading frames 1a and 1b indicates the presence of a shifty heptamer consensus sequence and downstream sequences that may be needed for ribosomal frameshifting. We constructed four astrovirus cassettes that spanned this region and inserted each into the rhesus rotavirus VP4 gene. The constructs were expressed in an in vitro system, and products were immunoprecipitated by rotavirus amino and carboxy terminal-specific monoclonal antibodies. Ribosomal frameshifting, at an efficiency of 6–7%, was demonstrated in all constructs containing the shifty heptamer and stem-loop. Deletion of the downstream sequence potentially involved in pseudoknot formation did not affect frameshifting efficiency. However, deletion of the shifty heptamer resulted in no detectable frameshift activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01315421
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  • 7
    Electronic Resource
    Electronic Resource
    Pleiotropic mutations in Saccharomyces cerevisiae affecting sterol uptake and metabolism (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Yeast 4 (1988), S. 93-106 
    Details
    ISSN: 0749-503X
    Keywords: yeast ; Saccharomyces ; sterol ; uptake ; mutations ; Life and Medical Sciences ; Genetics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Sterol uptake control mutants (upc-) have been isolated via ethylmethanesulfonate mutagenesis from wild-type Saccharomyces cerevisiae. These mutants are heme and sterol competent but possess the ability to accumulate exogenous sterol(s) under aerobic conditions. Previous demonstrate sterol uptake only in a hem-, erg- background; however, the Upc- strains described here are Hem+ and do not require exogenous sterol for growth. We were unable to obtain viable hem+, erg-, upc+ recombinants; such combinations appear to be lethal. Isolates of Upc mutants demonstrated different levels of sterol uptake, and sterol analysis revealed a broad phenotypic range with regard to amounts and accumulation of ergosterol and non-ergosterol sterols. Assays of acyl CoA: ergosterol acyltransferase and sterol ester hydrolase showed no apparent difference in activity between Upc mutants and the wild type.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/yea.320040203
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  • 8
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    Cell biology in neuroscience: Cellular and molecular mechanisms underlying axon formation, growth, and branching (2013)
    Rockefeller University Press
    Details
    Publication Date: 2013-09-17
    Description: Proper brain wiring during development is pivotal for adult brain function. Neurons display a high degree of polarization both morphologically and functionally, and this polarization requires the segregation of mRNA, proteins, and lipids into the axonal or somatodendritic domains. Recent discoveries have provided insight into many aspects of the cell biology of axonal development including axon specification during neuronal polarization, axon growth, and terminal axon branching during synaptogenesis.
    Keywords: Cell Biology in Neuroscience
    Electronic ISSN: 1540-8140
    Topics: Biology
    Published by Rockefeller University Press
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  • 9
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    Ambulance smartphone tool for field triage of ruptured aortic aneurysms (FILTR): study protocol for a prospective observational validation of diagnostic accuracy (2016)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2016-10-26
    Description: Introduction Rupture of an abdominal aortic aneurysm (rAAA) carries a considerable mortality rate and is often fatal. rAAA can be treated through open or endovascular surgical intervention and it is possible that more rapid access to definitive intervention might be a key aspect of improving mortality for rAAA. Diagnosis is not always straightforward with up to 42% of rAAA initially misdiagnosed, introducing potentially harmful delay. There is a need for an effective clinical decision support tool for accurate prehospital diagnosis and triage to enable transfer to an appropriate centre. Methods and analysis Prospective multicentre observational study assessing the diagnostic accuracy of a prehospital smartphone triage tool for detection of rAAA. The study will be conducted across London in conjunction with London Ambulance Service (LAS). A logistic score predicting the risk of rAAA by assessing ten key parameters was developed and retrospectively validated through logistic regression analysis of ambulance records and Hospital Episode Statistics data for 2200 patients from 2005 to 2010. The triage tool is integrated into a secure mobile app for major smartphone platforms. Key parameters collected from the app will be retrospectively matched with final hospital discharge diagnosis for each patient encounter. The primary outcome is to assess the sensitivity, specificity and positive predictive value of the rAAA triage tool logistic score in prospective use as a mob app for prehospital ambulance clinicians. Data collection started in November 2014 and the study will recruit a minimum of 1150 non-consecutive patients over a time period of 2 years. Ethics and dissemination Full ethical approval has been gained for this study. The results of this study will be disseminated in peer-reviewed publications, and international/national presentations. Trial registration number CPMS 16459; pre-results.
    Keywords: Open access, Diagnostics, Emergency medicine, Health services research, Public health, Surgery
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 10
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    Adoption of a novel surgical innovation into clinical practice: protocol for a qualitative systematic review examining surgeon views (2018)
    BMJ Publishing
    In: BMJ Open
    Details
    Publication Date: 2018-04-18
    Description: Introduction Efficient adoption of clinically effective novel surgical innovations has great potential benefits for patients. Factors affecting the adoption of surgical innovation are not well understood and proposed models of adoption do not accurately correlate with historical evidence. This protocol is for a systematic review that aims to identify the qualitative evidence relating to surgeon views regarding the adoption of novel surgical innovation into clinical practice. Methods and analysis A systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidance will be performed. Two independent reviewers will search the following databases: MEDLINE, Embase, Science Direct, Scopus, Web of Science and the Cochrane Library of Systematic Reviews. Inclusion criteria are studies which report on the views of surgeons who adopt a novel surgical innovation into clinical practice. Each article will be screened for inclusion and assessed according to a Critical Appraisal Skills Programme tool. Data will be synthesised and analysed according to thematic analysis. Given the anticipated yield of a small heterogeneous body of evidence meeting the eligibility criteria for the review, a narrative-based summary is planned. Ethics and dissemination This review does not require formal ethical approval as it does not involve direct patient contact or patient-identifiable data. The results of this review will be published in a peer-reviewed journal and presented at relevant conferences. The results will also inform an empirical qualitative study exploring surgeon and other stakeholder views regarding the introduction of novel surgical technology and procedures into clinical practice. PROSPERO registration number CRD42017076715.
    Keywords: Surgery, Open access, Surgery
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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