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  • 1
    ISSN: 1432-0533
    Keywords: Key words     AIDS ; Cytomegalovirus encephalitis ; Herpes virus encephalitis ; Cerebral lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract      Unlike cytomegalovirus (CMV) ventriculoencephalitis, herpes simplex virus type 1 necrotizing encephalitis has only rarely been observed in AIDS patients. A 40-year-old bisexual man was followed for an HIV1 infection from 1987 onwards. In June 1993 he was referred for sudden confusion, left hemiparesia and fever. The blood contained less than 10 CD4 lymphocytes/mm3. The patient remained comatose and febrile, and died 4 weeks later. In coronal sections of the brain there was necrosis of the internal parts of the left temporal lobe, necrosis of certain areas of the ventricular walls and a small tumor at the top of the right frontal lobe, which proved to be a polymorphic high-grade lymphoma. CMV ventriculoencephalitis lesions were prominent in the ventricular walls of the occipital lobes and there was a strong nuclear signal for CMV using in situ hybridization. Herpes simplex virus type 1 was shown in the nuclei and cytoplasm of certain neurons and astrocytes in the borders of the necrotized temporal lobe areas by immunohistochemistry, in situ hybridization and electron microscopy, whereas in situ hybridization and immunohistochemistry for CMV were negative in such areas. Necrotizing type 1 encephalitis must not be overlooked in immunodeficient patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: AIDS ; Cytomegalovirus encephalitis ; Herpes virus encephalitis ; Cerebral lymphoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Unlike cytomegalovirus (CMV) ventriculoencephalitis, herpes simplex virus type 1 necrotizing encephalitis has only rarely been observed in AIDS patients. A 40-year-old bisexual man was followed for an HIV1 infection from 1987 onwards. In June 1993 he was referred for sudden confusion, left hemiparesia and fever. The blood contained less than 10 CD4 lymphocytes/mm3. The patient remained comatose and febrile, and died 4 weeks later. In coronal sections of the brain there was necrosis of the internal parts of the left temporal lobe, necrosis of certain areas of the ventricular walls and a small tumor at the top of the right frontal lobe, which proved to be a polymorphic high-grade lymphoma. CMV ventriculoencephalitis lesions were prominent in the ventricular walls of the oecipital lobes and there was a strong nuclear signal for CMV using in situ hybridization. Herpes simplex virus type 1 was shown in the nuclei and cytoplasm of certain neurons and astrocytes in the borders of the necrotized temporal lobe areas by immunohistochemistry, in situ hybridization and electron microscopy, whereas in situ hybridization and immunohistochemistry for CMV were negative in such areas. Necrotizing type 1 encephalitis must not be overlooked in immunodeficient patients.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-7284
    Keywords: Cytomegalovirus ; HIV ; Opportunistic infections ; Prognostic factors ; Protease inhibitors ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To analyse survival of HIV-infected patients who developed cytomegalovirus (CMV) disease and to identify prognostic factors of their survival. Methods: Cases of CMV disease diagnosed in the Aquitaine Cohort of HIV-infected patients (n = 4297) during the 1986–1996 period, were reviewed using standardised definitions. Follow-up was extended to December 1997. Cox model was used to determine factors associated with survival after the initial manifestations of CMV disease, considering protease inhibitor (PI) prescription and anti-CMV treatment as time dependent covariates. Results: 253 patients presented a CMV disease of which 221 (87.3%) died (median survival: 7 months). A better prognosis for survival was associated with: PI prescription [relative hazard (RH): 0.26; 95% confidence interval (CI): 0.11–0.59], anti-CMV treatment (RH: 0.37; CI: 0.25–0.54), CD4+ lymphocyte cell count 〉 50/mm3(RH: 0.66; CI: 0.47–0.94) and absence of neoplasia (RH: 0.70; CI: 0.52–0.94) whereas the disseminated CMV disease worsened prognosis (RH: 1.83; CI: 1.20–2.80). Conclusion: Antiretroviral treatment including PI, improved short-term prognosis of CMV disease regardless of its clinical manifestations.
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2021-06-14
    Description: In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the “Green” Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instruments’ development and satellite missions’ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion.
    Language: English
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 5
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    In:  XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)
    Publication Date: 2023-07-18
    Description: In the context of the ESA CCI Coastal Sea Level project, a complete reprocessing of high resolution along-track altimetry data of the Jason-1, Jason-2 and Jason-3 missions over January 2002 to January 2020 was performed along the world coastal zones. This reprocessing has provided valid sea level data in the 0-15 km band from the coast. A total of 750+ altimetry-based virtual coastal stations have been selected and sea level anomalies time series together with associated coastal sea level trends have been computed over the 2002-2020 time span. These virtual stations offer a unique tool for estimating sea level change close to the coast (typically up to 3 km to the coast but in many instances up to 1 km or even closer), especially in the coastal regions devoid from tide gauges. Results show that at about 90% of the virtual stations, the rate of sea level rise at the coast is similar to the rate offshore (15+ km away from the coast). In the remaining 10%, the sea level rate within 4-5 km from the coast is either faster or slower than offshore. In this presentation, we focus on a few coastal sites where the rate of sea level rise differs from that offshore. We discuss potential small-scale coastal processes (e.g., changes in shelf currents, waves, fresh water input from river runoff in deltas and estuaries, etc.) able to explain the observations.
    Language: English
    Type: info:eu-repo/semantics/conferenceObject
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